Genotoxic impact of long-term cigarette and waterpipe smoking on DNA damage and oxidative stress in healthy subjects حسب Alsaad A.M.

"…This was associated with a marked decrease (50%) in the expression of detoxifying genes (NQO1 and GSTA1) with an increase in CYP1A1 mRNA expression, a cancer-activating gene. …"
احصل على النص الكامل
احصل على النص الكامل

The Interference of Notch1 target Hes1 affects cell growth, differentiation and invasiveness of glioblastoma stem cells through modulation of multiple oncogenic targets حسب Cenciarelli, Carlo

"…Depletion of Hes1 protein induces major changes in cell morphology, cell growth rate and in the invasive ability of shHes1-CSC in response to growth factor EGF. shHes1-CSC show a decrease of the stemness marker Nestin concurrently to a marked increase of neuronal marker MAP2 compared to pLKO.1-CSC. …"
احصل على النص الكامل

Effect of hypoxia on metabolic markers and gene expression HIF-1 α in adipocytes حسب Younes, Noura B.

"…The exposure of adipocytes to 1% hypoxia significantly alters the transcript of hypoxia genes, and other genes involved in glucose (GLUT1, GLUT4) and lipid (PPAR-γ) metabolism, and is also linked to anaerobic metabolism with apoptosis and increased oxidative stress. …"
احصل على النص الكامل

MOLECULAR FEATURES OF TRIPLE NEGATIVE BREAST CANCER STEM CELLS: A GENE EXPRESSION PROFILING ANALYSIS OF MDA-MB-231 CELLS حسب Hourani, Shireen Bayan

"…We determined the mRNA and protein expressions of genes responsible for stemness markers, autophagy, apoptosis, CYP450 enzymes, and tumor suppressors TNBC and CSCs. …"
احصل على النص الكامل

Structural analysis of missense mutations in galactokinase 1 (GALK1) leading to galactosemia type-2. حسب P, Sneha

"…Galactosemia type 2 is an autosomal recessive disorder characterized by the deficiency of galactokinase (GALK) enzyme due to missense mutations in GALK1 gene, which is associated with various manifestations such as hyper galactosemia and formation of cataracts. …"
احصل على النص الكامل
احصل على النص الكامل

Investigation of the Effect of Imatinib and Hydroxyurea Combination Therapy on Hematological Parameters and Gene Expression in Chronic Myeloid Leukemia (CML) Patients حسب Al-Amleh, Esraa K.

"…Platelet counts, on the other hand, dramatically decreased in both IM and (HU + IM). (4) Conclusion: Because the studied genes (BCL2, PP2A, CIP2A, and WT1) are participating in cell proliferation and death, the findings show that the examined genes are significant to understand the efficacy of various therapies. …"
احصل على النص الكامل
احصل على النص الكامل

Functionally graded porous femoral stem: Computational Analysis حسب Tarlochan F.

"…The gradation scheme was decreasing the porosity distally. From this study, it was found that functionally graded porous stems in comparison to fully dense stems, transfers up to 170% of the stresses to the bone (reduce stress shielding) and have micromotion that supports bone in growth.…"
احصل على النص الكامل
احصل على النص الكامل

MYD88, IRAK3 and Rheumatoid Arthritis pathogenesis: Analysis of differential gene expression in CD14 + monocytes and the inflammatory cytokine levels. حسب Gomes da Silva, Isaura Isabelle Fonseca

"…No significant differences were observed for MYD88 gene expression (FC = 1.20; p = 0.294) between patients and controls analyzed. …"
احصل على النص الكامل
احصل على النص الكامل

Credit bureaus and financial constraints do corruption matter? حسب Ben Ali, Mohamed Sami

احصل على النص الكامل
احصل على النص الكامل

Differentiation of human olfactory bulb-derived neural stem cells toward oligodendrocyte. حسب Marei, Hany E

"…In addition, a significant up regulation in gene and protein expression profile of stage specific cell markers for OPCs/OLs (CNPase, Galc, NG2, MOG, OLIG1, OLIG2, MBP), neurons, and astrocytes (MAP2, β-TubulinIII, GFAP) and concomitant decrease of OBNSCs pluripotency markers (Oct4, Sox2, Nestin), was demonstrated following induction of OBNSCs differentiation. …"
احصل على النص الكامل
احصل على النص الكامل

Methylated pentavalent arsenic metabolites are bifunctional inducers, as they induce cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase through AhR- and Nrf2-dependent mechanis... حسب Anwar-Mohamed, Anwar

احصل على النص الكامل
احصل على النص الكامل

Novel potentials of the DPP-4 inhibitor sitagliptin against ischemia-reperfusion (I/R) injury in rat ex-vivo heart model حسب Al-Awar A.

"…Hearts were then isolated and subjected to two different I/R injury protocols: 10 min perfusion, 45 min regional ischemia, and 120 min reperfusion for infarct size (IS) measurement, or: 10 min perfusion, 45 min regional ischemia and 10 min reperfusion for biochemical analysis: nitric oxide synthases (NOSs) and DPP-4 activity, glucagon-like peptide-1 (GLP-1), Calcium, transient receptor potential vanilloid (TRPV)-1 and calcitonin gene-related peptide (CGRP) levels, transient receptor potential canonical (TRPC)-1 and e-NOS protein expression. …"
احصل على النص الكامل
احصل على النص الكامل

PROFILE OF OXIDATIVE STRESS GENES IN RESPONSE TO OBESITY TREATMENT حسب AHMED, AMIRA

"…Aim: This study explores the impact of SNF on OS in diet induced obese (DIO) mice via profiling of OS genes and pathways in skeletal muscles related to the anti-obesity effect. …"
احصل على النص الكامل
احصل على النص الكامل

Fabrication of zno-fe-mxene based nanocomposites for efficient co2 reduction حسب Kannan, K.

"…The micrographs of the SEM showed nanoparticles with a flower-like structure. …"
احصل على النص الكامل
احصل على النص الكامل

Finite element study of functionally graded porous femoral stems incorporating body-centered cubic structure حسب Alkhatib, Sami E.

"…Three levels of porosities (20%, 50%, and 80%) were modeled in HGP and FGP stems. The porosity of the stems was decreased distally according to the sigmoid function (n = 0.1, n = 1 and n = 10) with 3 grading exponents. …"
احصل على النص الكامل
احصل على النص الكامل

Differences in the neovascular potential of thymus versus subcutaneous adipose-derived stem cells from patients with myocardial ischemia. حسب Oliva-Olivera, Wilfredo

احصل على النص الكامل
احصل على النص الكامل

Phase, microstructure and tensile strength of Al–Al2O3–C hybrid metal matrix composites حسب Ahamad, N.

احصل على النص الكامل
احصل على النص الكامل

Structural and mechanical characterization of stir cast Al–Al2O3–TiO2 hybrid metal matrix composites حسب Ahamad, N.

احصل على النص الكامل
احصل على النص الكامل

CD44 mediates stem cell mobilization to damaged lung via its novel transcriptional targets, Cortactin and Survivin حسب Ouhtit, Allal

"…Beyond their role in bone and lung homeostasis, mesenchymal stem cells (MSCs) are becoming popular in cell therapy. …"
احصل على النص الكامل
احصل على النص الكامل

Metformin attenuates V-domain Ig suppressor of T-cell activation through the aryl hydrocarbon receptor pathway in Melanoma: In Vivo and In Vitro Studies حسب Fawaz E., Alanazi

"…Here, metformin significantly decreased VISTA and AHR levels in vitro and in vivo. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل