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a decrease » _ decreased (توسيع البحث), _ decreases (توسيع البحث)
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_ 12 » _ 2 (توسيع البحث), _ 1 (توسيع البحث), _ 10 (توسيع البحث)
a decrease » _ decreased (توسيع البحث), _ decreases (توسيع البحث)
1 step » a step (توسيع البحث), _ step (توسيع البحث)
_ 12 » _ 2 (توسيع البحث), _ 1 (توسيع البحث), _ 10 (توسيع البحث)
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Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle
منشور في 2023"…We investigated protein glycation and oxidative damage in skeletal muscle of mice with UCP1 expression under control of the human skeletal actin promoter (HSA-mUCP1) at age 12 weeks (young) and 70 weeks (aged). We found both young and aged HSA-mUCP1 mice had decreased advanced glycation endproducts (AGEs) formed from MG, lysine-derived Nε(1-carboxyethyl)lysine (CEL) and arginine-derived hydroimidazolone, MG-H1, whereas protein glycation by glucose forming Nε-fructosyl-lysine (FL) was increased ca. 2-fold, compared to wildtype controls. …"
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Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle
منشور في 2023"…We investigated protein glycation and oxidative damage in skeletal muscle of mice with UCP1 expression under control of the human skeletal actin promoter (HSA-mUCP1) at age 12 weeks (young) and 70 weeks (aged). We found both young and aged HSA-mUCP1 mice had decreased advanced glycation endproducts (AGEs) formed from MG, lysine-derived Nε(1-carboxyethyl)lysine (CEL) and arginine-derived hydroimidazolone, MG-H1, whereas protein glycation by glucose forming Nε-fructosyl-lysine (FL) was increased ca. 2-fold, compared to wildtype controls. …"
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12/15-Lipoxygenase-Derived Lipid Metabolites Induce Retinal Endothelial Cell Barrier Dysfunction: Contribution of NADPH Oxidase
منشور في 2013"…VEGF-R2 inhibitor reduced the permeability effect of 12-HETE. Treatment of REC with HETE also increased ROS generation and expression of NOX2 and pVEGF-R2 and decreased pSHP1 expression. …"
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Structural analysis of missense mutations in galactokinase 1 (GALK1) leading to galactosemia type-2.
منشور في 2018"…Galactosemia type 2 is an autosomal recessive disorder characterized by the deficiency of galactokinase (GALK) enzyme due to missense mutations in GALK1 gene, which is associated with various manifestations such as hyper galactosemia and formation of cataracts. …"
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Chemical characterization and therapeutic properties of Achillea biebersteinii leaf aqueous extract synthesized copper nanoparticles against methamphetamine-induced cell death in P...
منشور في 2020"…In particular, both doses of CuNPs significantly (p ≤ 0.01) increased cell viability and NO production, and decreased cell cytotoxicity, cell death index, and caspase-3 activity near the normal. …"
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The Effect of Visual Impairment and Its Severity on Vision-Related and Health-Related Quality of Life in Jordan: A Comparative Cross-Sectional Study
منشور في 2023"…An interviewer administered the National Eye Institute Visual Function Questionnaire (NEI VFQ-25) and the Medical Outcomes Study 12-Item Short Form Health Survey (SF-12) to all participants. …"
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Molecular properties prediction, anticancer and anti-inflammatory activities of some pyrimido[1,2-b]pyridazin-2-one derivatives
منشور في 2023"…Introduction: The anticancer and anti-inflammatory activities of a novel series of eleven pyrimido[1,2-b]pyridazin-2-one analogues substituted at position 7 were assessed in the current study. …"
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A lipidomic screen of hyperglycemia-treated HRECs links 12/15-Lipoxygenase to microvascular dysfunction during diabetic retinopathy via NADPH oxidase
منشور في 2015"…Fluorescein angiography and retinal albumin leakage showed a significant decrease in retinal hyperpermeability in streptozotocin-induced diabetic mice lacking 12/15-LOX compared with diabetic WT mice. …"
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Urology Residents' Perspectives on the In-House On-Call Systems: A Study in an Accredited Academic Center
منشور في 2022"…However, the total number of duty hours violations decreased in the 12-hour on-call system. Conclusion: The 12-hour system is a better alternative to the 24-hour system in terms of the resident's quality of life, education, surgical case volume, and compliance with duty hour rules.…"
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Inner sphere oxidation of N,N′-ethylenebis(isonitrosoacetyleacetoneimine)copper(II) by N-bromosuccinimide in aqueous weakly acidic solutions
منشور في 2013"…The mechanism of the title reaction is consistent with an inner sphere mechanism in which a pre-equilibrium step precedes the electron transfer step. The overall rate law is represented by Eq. (2) where [CuIL]t and K 1 represent the total copper(II) complex concentration and the pre- equilibrium formation constant, respectively. d [CuL+]/dt = {(ko+k₁ [H+]) [SBr] [CuL]}/(1 + K₁ [SBr])…"
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Genotoxic impact of long-term cigarette and waterpipe smoking on DNA damage and oxidative stress in healthy subjects
منشور في 2019"…Our results showed that 80% of the participants smoke 20-39 cigarettes/day, whereas 12% smoke more than 40 cigarettes/day. With regard to waterpipe smoke, the majority (46%) smoke more than 5 times/week. …"
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Determining the role of missense mutations in the POU domain of HNF1A that reduce the DNA-binding affinity: A computational approach
منشور في 2017"…Missense mutations of the HNF1A were retrieved from public databases and subjected to a three-step computational mutational analysis to identify the underlying mechanism. …"
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Coral reef resilience differs among islands within the Gulf of Mannar, southeast India, following successive coral bleaching events
منشور في 2021"…We used a 12-yr data set of benthic cover (2005�2017), spanning two bleaching events, to assess changes in benthic cover and coral community composition along 21 islands within Gulf of Mannar (GoM), southeast India. …"
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A computational approach for investigating the mutational landscape of RAC-alpha serine/threonine-protein kinase (AKT1) and screening inhibitors against the oncogenic E17K mutation...
منشور في 2019"…The molecular interaction study also revealed that the co-crystallized AKT1 inhibitor N-(4-(5-(3-acetamidophenyl)-2-(2-aminopyridin-3-yl)-3H-imidazo [4,5-b]pyridin-3-yl)benzyl)-3-fluorobenzamide (12j) exhibited a better interaction with native AKT1 compared with the E17K mutant AKT1 protein, whereas, Akti-1/2 exhibited the opposite effects, i.e., a better interaction with the E17K mutant AKT1 than the native AKT1. …"
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