بدائل البحث:
a decrease » _ decreased (توسيع البحث), _ decreases (توسيع البحث)
_ decrease » _ decreased (توسيع البحث), _ decreases (توسيع البحث), _ decreasing (توسيع البحث)
a step » a stem (توسيع البحث)
_ akt » _ art (توسيع البحث)
a decrease » _ decreased (توسيع البحث), _ decreases (توسيع البحث)
_ decrease » _ decreased (توسيع البحث), _ decreases (توسيع البحث), _ decreasing (توسيع البحث)
a step » a stem (توسيع البحث)
_ akt » _ art (توسيع البحث)
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Oxidative stress-induced Akt downregulation mediates green tea toxicity towards prostate cancer cells
منشور في 2017"…Failure of PE to induce PC3 damage in cells overexpressing Akt further confirms its implication in the PE-elicited cell death. …"
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Greensporone C, a Freshwater Fungal Secondary Metabolite Induces Mitochondrial-Mediated Apoptotic Cell Death in Leukemic Cell Lines
منشور في 2018"…Treatment with GC suppressed constitutively phosphorylated AKT and downregulated expression of inhibitor of apoptotic proteins XIAP, cIAP-1, and cIAP-2. …"
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A computational approach for investigating the mutational landscape of RAC-alpha serine/threonine-protein kinase (AKT1) and screening inhibitors against the oncogenic E17K mutation...
منشور في 2019"…We also performed a virtual screening analysis with 19 AKT inhibitors obtained from the Selleck Chemicals website those satisfied the Lipinski rule of 5. …"
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Salvia fruticosa Induces Vasorelaxation in Rat Isolated Thoracic Aorta: Role of the PI3K/Akt/eNOS/NO/cGMP Signaling Pathway
منشور في 2017"…Furthermore, SF induced Akt phosphorylation as well as increased cGMP levels in rings treated with increasing doses of SF. …"
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Protein arginine methyltransferase 5 (PRMT5) promotes survival of lymphoma cells via activation of WNT/B-catenin and AKT/GSK3B proliferative signaling
منشور في 2019"…We show that PRMT5 stimulates WNT/B-CATENIN signaling through direct epigenetic silencing of pathway antagonists, AXIN2 and WIF1, and indirect activation of AKT/GSK3 signaling.PRMT5 inhibition with either shRNA-mediated knockdown or a specific small molecule PRMT5 inhibitor, CMP-5, not only leads to derepression of WNT antagonists and decreased levels of active phospho-AKT (Thr-450 and Ser-473) and inactive phospho- GSK3B (Ser-9) but also results in decreased transcription of WNT/B-CATENIN target genes, CYCLIN D1, c-MYC, and SURVIVIN, and enhanced lymphoma cell death. …"
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Signaling pathways activated by PACAP in MCF-7 breast cancer cells
منشور في 2018"…Moreover, selective inhibition of Src or PI3K resulted in a significant decrease in the phosphorylation of ERK and AKT, but not p38, demonstrating that PACAP signaling follows Src/Raf/ERK and PI3K/AKT pathways. …"
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Olive Leaves Extract and Oleuropein Improve Insulin Sensitivity in 3T3-L1 Cells and in High-Fat Diet-Treated Rats via PI3K/AkT Signaling Pathway
منشور في 2023"…Moreover, the cotreatment of EE 1/1000 or oleuropein with insulin increased considerably the expression of p-IRS, p85-pI3K, and p-AKT. In vivo model, the oral administration of oleuropein at 50 mg/kg in rats fed with high fat diet for 8 weeks reduced inflammation in liver and adipose tissues (WAT), improved glucose intolerance, and decreased hyperinsulinemia. …"
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A Reverse MultipleChoice Based mLearning System
منشور في 2018"…Using a knowledge base, a set of answer choices will be created for a multiple-choice question. …"
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Inner sphere oxidation of N,N′-ethylenebis(isonitrosoacetyleacetoneimine)copper(II) by N-bromosuccinimide in aqueous weakly acidic solutions
منشور في 2013"…The mechanism of the title reaction is consistent with an inner sphere mechanism in which a pre-equilibrium step precedes the electron transfer step. …"
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Determining the role of missense mutations in the POU domain of HNF1A that reduce the DNA-binding affinity: A computational approach
منشور في 2017"…Missense mutations of the HNF1A were retrieved from public databases and subjected to a three-step computational mutational analysis to identify the underlying mechanism. …"
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A new insight into the separation of oil from oil/water emulsion by Fe3O4?SiO2 nanoparticles
منشور في 2021"…Moreover, the results exhibited that the reservoir conditions are a crucial function for increasing the oil recovery rates, improving the emulsion stability, and acts as a substantial step for the oil recovery method that applies this particular technique.…"
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A process for CO2 capture and brine salinity reduction through reaction with potassium hydroxide: A multi-stage evaluation
منشور في 2022"…Solvay and modified Solvay processes are facing a major challenge in reducing brine salinity to a level suitable for agriculture and industry. …"
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Appropriateness of gentamicin therapeutic drug monitoring at a Middle Eastern tertiary hospital setting: a retrospective evaluation and quality audit
منشور في 2024"…Objective: This study aimed to evaluate the appropriateness of gentamicin therapeutic drug monitoring (TDM) at a tertiary care hospital in Qatar. Methods: A one-year quantitative retrospective chart review of all gentamicin TDM records was conducted. …"
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20
On the application of arabian gulf water in irrigation: A future possibility
منشور في 1987"…Barley can tolerate 12 dS m water salinity without any apparent yeild decrement. Yield would decrease by 5% per each additional increment in water salinity beyond 12 dS m Thus, if Gulf water salinity was treated according to the model of plant response to time weighted salinity, then barley could alternatively be irrigated with fresh/Gulf water in a way that would save a minimum of 16% of the applied water. …"
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