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Genotoxic impact of long-term cigarette and waterpipe smoking on DNA damage and oxidative stress in healthy subjects
Published 2019“…Therefore, the present study provides molecular evidence for a pathway involved in the DNA damage induced by long-term cigarette and waterpipe smoke in human subjects. …”
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Determining the role of missense mutations in the POU domain of HNF1A that reduce the DNA-binding affinity: A computational approach
Published 2017“…Over the past years, several studies have reported the association of missense mutations in the Hepatocyte Nuclear Factor 1 Alpha (HNF1A) with MODY3. Missense mutations in the POU homeodomain (POUH) of HNF1A hinder binding to the DNA, thereby leading to a dysfunctional protein. …”
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Biophysical studies of the effect of high power ultrasound on the DNA solution
Published 2014“…The decrease in the dielectric increment indicated a decrease in length of DNA molecule after exposure to ultrasound power.…”
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A computational model to predict the structural and functional consequences of missense mutations in O6-methylguanine DNA methyltransferase
Published 2019“…DNA repair mechanism is a process through which the cell repairs its damaged DNA. …”
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Elucidating the role of interacting residues of the MSH2-MSH6 complex in DNA repair mechanism: A computational approach.
Published 2019“…The DNA repair system is crucial to repair the error resulting in DNA replication. …”
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Structural analysis of missense mutations in galactokinase 1 (GALK1) leading to galactosemia type-2.
Published 2018“…As the next step, comparative physicochemical changes of the native and the mutant proteins were carried out using essential dynamics. …”
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Inner sphere oxidation of N,N′-ethylenebis(isonitrosoacetyleacetoneimine)copper(II) by N-bromosuccinimide in aqueous weakly acidic solutions
Published 2013“…The value of the observed rate constant, k obs, increases with decreasing pH. At constant reaction conditions, the dependence of the observed rate constants, k obs, is described by Eq. (1). kobs = ko + k1 [H+] The dependence of both kand k 1 on [SBr] is not linear. …”
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A computational approach for investigating the mutational landscape of RAC-alpha serine/threonine-protein kinase (AKT1) and screening inhibitors against the oncogenic E17K mutation...
Published 2019“…The molecular interaction study also revealed that the co-crystallized AKT1 inhibitor N-(4-(5-(3-acetamidophenyl)-2-(2-aminopyridin-3-yl)-3H-imidazo [4,5-b]pyridin-3-yl)benzyl)-3-fluorobenzamide (12j) exhibited a better interaction with native AKT1 compared with the E17K mutant AKT1 protein, whereas, Akti-1/2 exhibited the opposite effects, i.e., a better interaction with the E17K mutant AKT1 than the native AKT1. …”
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Appropriateness of gentamicin therapeutic drug monitoring at a Middle Eastern tertiary hospital setting: a retrospective evaluation and quality audit
Published 2024“…Objective: This study aimed to evaluate the appropriateness of gentamicin therapeutic drug monitoring (TDM) at a tertiary care hospital in Qatar. Methods: A one-year quantitative retrospective chart review of all gentamicin TDM records was conducted. …”
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On the application of arabian gulf water in irrigation: A future possibility
Published 1987“…Barley can tolerate 12 dS m water salinity without any apparent yeild decrement. Yield would decrease by 5% per each additional increment in water salinity beyond 12 dS m Thus, if Gulf water salinity was treated according to the model of plant response to time weighted salinity, then barley could alternatively be irrigated with fresh/Gulf water in a way that would save a minimum of 16% of the applied water. …”
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Ultra-low thermal conductivity in scheelite and A-deficient scheelite ceramics
Published 2021“…BaMoO ceramic has shown a decrease in thermal conductivity from 0.8 W m K to 0.65 W m K from 400 K to 650 K. …”
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