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mean decrease » a decrease (Expand Search)
wt decrease » we decrease (Expand Search), a decrease (Expand Search), nn decrease (Expand Search)
_ decrease » _ decreased (Expand Search)
e decrease » a decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
5 wt » _ wt (Expand Search), 5 ht (Expand Search)
mean decrease » a decrease (Expand Search)
wt decrease » we decrease (Expand Search), a decrease (Expand Search), nn decrease (Expand Search)
_ decrease » _ decreased (Expand Search)
e decrease » a decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
5 wt » _ wt (Expand Search), 5 ht (Expand Search)
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Brain and liver GCase activity are significantly decreased in heterozygous <i>GBA1</i> D409V KI mice, with varying differences in glucosphingolipid lipids in brain and liver.
Published 2021“…<p>(A-B) GCase, (C-D) gluocosylceramide (GlcCer), and (E-F) glucosylsphingosine (GlcSph) levels measured in whole brain homogenate and liver homogenate of C57Bl/6 wild type (WT) and <i>GBA1</i> D409V KI heterozygous (HET) mice at 5 months of age (n = 10/age). …”
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GCase activity is significantly decreased in the brain and liver of the homozygous <i>GBA1</i> D409V KI mouse model at 4, 8, and 12 months of age.
Published 2021“…In whole brain homogenate (A,C) and liver homogenate (B,D), GCase activity is significantly decreased in the <i>GBA1</i> D409V KI homozygous (HOM) mice as compared to C57Bl/6 wild type (WT) mice (n = 7/group). …”
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Spatial training decreases endogenous PTEN ubiquitination and <i>Pten</i> cKO mice show impaired spatial learning and memory.
Published 2023“…Endogenous PTEN ubiquitination level is decreased in Nedd4 siRNA-transfected rats (t<sub>1,6</sub> = 5.92, <i>p</i> = 0.001). …”
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Effects of vidarabine, V2E, V3E and V5E on AC activity in the heart of WT and AC5KO mice.
Published 2025“…<p>(A) Vidarabine (Vida), V2E, V3E and V5E similarly and significantly decreased ISO (50 µmol/L)-stimulated AC activity in the WT heart in a dose-dependent manner. …”
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WT1 siRNA decreases proliferation, pAKT, and Bcl2 expression.
Published 2024“…<b>C.</b> RT-qPCR of WT1, p<0.05(*), vFLIP(ns), LANA, p<0.0001(****), K8.1, p<0.0001(****), and BCL2 p<0.05(*) in the setting of WT1 knockdown in ISLK BAC-16 with WT1 siRNA in comparison to a control siRNA using two-sided, unpaired student’s t-tests. …”
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