Cost-effectiveness and budget impact of immediate antiretroviral therapy initiation for treatment of HIV infection in Côte d’Ivoire: A model-based analysis by Eric N. Ouattara (6890174)

“…<i>Immediate ART</i> increased the 5-year HIV care budget from $801.9M to $812.6M compared to <i>ART<350/μL</i>.</p><p>Conclusions</p><p>In Côte d’Ivoire, immediate compared to later ART initiation will increase life expectancy, decrease HIV transmission, and be cost-effective over the long-term, with modest budget impact. …”

rHSP60 decreases viability of B lymphocyte cell line but not macrophage one. by Igor Emiliano L. Souza (18196495)

Conditional ablation of <i>Ybx1</i> leads to a reduction in cortical progenitor cell pool and a decrease in cortical thickness. by Jian Zhang (1682)

Image_1_Electroencephalographic Evidence for Individual Neural Inertia in Mice That Decreases With Time.JPEG by Andrzej Z. Wasilczuk (11945885)

“…EEG was measured after induction of and emergence from isoflurane administered near the EC₅₀ dose for loss of righting in genetically inbred mice on a timescale that minimizes pharmacokinetic confounds. …”

Decreased ISCs and increased goblet cells after intestinal specific loss of MLL1. by Neha Goveas (11790822)

“…<p><b>(A)</b> Kaplan-Meier survival curve. Tamoxifen was given by gavage for 6 days to mice with the genotype <i>Mll1</i>^{<i>FC/+; Vil-Cre-ERT2/+</i>} (n = 12) and <i>Mll1</i>^{<i>FC/FC; RC/+</i>} (n = 18). …”

Image_1_Decreased Systemic and Airway Sirtuin 1 Expression in Adults With Bronchiectasis.TIF by Xiao-rong Han (8470563)

Image_3_Decreased Systemic and Airway Sirtuin 1 Expression in Adults With Bronchiectasis.TIF by Xiao-rong Han (8470563)

Image_2_Decreased Systemic and Airway Sirtuin 1 Expression in Adults With Bronchiectasis.JPEG by Xiao-rong Han (8470563)

Table_2_Decreased Systemic and Airway Sirtuin 1 Expression in Adults With Bronchiectasis.DOCX by Xiao-rong Han (8470563)

Image_4_Decreased Systemic and Airway Sirtuin 1 Expression in Adults With Bronchiectasis.TIF by Xiao-rong Han (8470563)

Experiments were conducted in the operant conditioning box (A, protocols 1–6) or a home cage (B, protocol 6). by Agnieszka D. Wardak (17941139)

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…Structure–activity relationship study reveals that ethyl group substituent hydrazide-based ZBG and cap group with more substantial rigidity and larger volume increase the HDAC6 selectivity of designed compounds. Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC₅₀ value of 0.019 μM. …”

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…Structure–activity relationship study reveals that ethyl group substituent hydrazide-based ZBG and cap group with more substantial rigidity and larger volume increase the HDAC6 selectivity of designed compounds. Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC₅₀ value of 0.019 μM. …”

GXM decreases the trans-endothelial electrical resistance (TEER) and transmigration of <i>C</i>. <i>neoformans</i> through HBECs in a blood brain barrier (BBB) model. by Hiu Ham Lee (15374677)

Contribution of direct emissions, seed, compost, other field operations, irrigation, mineral fertilisers, pesticides and transport of inputs to the climate change impact of conservation agriculture popcorn as a function of the percentage of impact allocated to compost: 7.2% (this study), 3.6% (50% decrease), 10.8% (50% increase), and 100% (original life cycle inventory from AGRIBALYSE; Avadi (2020)). by Maria Vittoria Guidoboni (15852669)

“…<p>Contribution of direct emissions, seed, compost, other field operations, irrigation, mineral fertilisers, pesticides and transport of inputs to the climate change impact of conservation agriculture popcorn as a function of the percentage of impact allocated to compost: 7.2% (this study), 3.6% (50% decrease), 10.8% (50% increase), and 100% (original life cycle inventory from AGRIBALYSE; Avadi (2020)).…”

Fig 6 - by Xiaolan Liu (294511)

Lethal time (mean LT₅₀ and LT₉₀ with 95% confidence limits) for aphid populations from different agroecological zones exposed to six entomopathogenic fungal i... by Aime Cheoh Enoh (20141758)

Partial correlation of <i>ε</i>_max (left column) and IC₅₀ (right column) estimates at 10 days and 20 days (first and second bar of each color, respectively) o... by Hope Murphy (8843516)

Development of (2-(Benzyloxy)phenyl)methanamine Derivatives as Potent and Selective Inhibitors of CARM1 for the Treatment of Melanoma by Zhihao Liu (419349)

“…In our previous study, we have identified a series of type I PRMT inhibitors, among which ZL-28-6 (<b>6</b>) exhibited increased activity against CARM1 while displaying decreased potency against other type I PRMTs. …”

Development of (2-(Benzyloxy)phenyl)methanamine Derivatives as Potent and Selective Inhibitors of CARM1 for the Treatment of Melanoma by Zhihao Liu (419349)

“…In our previous study, we have identified a series of type I PRMT inhibitors, among which ZL-28-6 (<b>6</b>) exhibited increased activity against CARM1 while displaying decreased potency against other type I PRMTs. …”