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41
Effect of hypoxia on metabolic markers and gene expression HIF-1 α in adipocytes
Published 2015“…Results: Under hypoxia conditions, DHA treatment resulted in significant changes in all critical parameters of adipocyte biology including HIF-1α RNA expression (decreased by 50%), decreased lactate and glycerol release (66% and 25% respectively), and reactive oxygen species (ROS) production (decreased by 15%), while glucose uptake was decreased by 25% accompnied by decreased secretion of pro-inflammatory markers (Interleukin 6 IL-6, 31% reduction) , macrophage chemoattractant protein 1 MCP-1 (38% reduction) and leptin (14% reduction), and increased adiponectin secretion (by 45%). …”
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The Cellular Interplay Between Na+/H+ Exchanger Isoform I and Osteopontin in Cardiac Hypertrophy
Published 2014“…OPN appeared to contribute to NHE1-induced CH independent of extracellular-signal-regulated kinases, p90-ribosomal-S6 kinase and protein kinase B (Akt). …”
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Comparing Methods for Induction of Insulin Resistance in Mouse 3T3-L1 Cells.
Published 2024“…We induced insulin resistance in 3T3-L1 cells using IL-6, TNFα, 4HNE, and high insulin in both hypoxic and normoxic conditions. …”
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Study of Magnetic Properties and Lattice Dynamics of the Cdx Co1-x Ferrite System by MossbauerEffect
Published 1981“…The results showed that the samples with x = 0.0 up to 0.5 are ferrimagnetic at room temperature, and a magnetic disorder transformation started to appear at x = 0.6. The Neel temperature was found to decrease with increasing cadmium concentration. …”
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Erratum: ITRAQ-based Quantitative Protein Expression Profiling and MRM Verification of Markers in Type 2 Diabetes (Journal of Proteome Research (2012) 11 (5527-5537) DOI: 10.1021/p...
Published 2013“…As expected, the diabetic cohort showed an elevation in serum glucose, HbA1c, and insulin levels and a decrease in the serum levels of Vitamin D and HDL .Addition/Correctionpubs.acs.org/jpr © 2013 American Chemical Society 1065 dx.doi.org/10.1021/pr4000224 | J. …”
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Docosahexaenoic Acid Counteracts the Hypoxic-Induced Inflammatory and Metabolic Alterations in 3T3-L1 Adipocytes
Published 2022“…In addition, DHA-treatment of hypoxic cells caused a significant reduction in the apoptosis rate and ROS production with decreased lipid peroxidation. Moreover, DHA-treatment of hypoxic cells caused a decreased secretion of pro-inflammatory markers (IL-6, MCP-1) and leptin and increased adiponectin secretion compared with hypoxic cells. …”
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In vitro evaluation of Neosetophomone B inducing apoptosis in cutaneous T cell lymphoma by targeting the FOXM1 signaling pathway
Published 2023“…Moreover, NSP-B suppressed FOXM1-regulated genes, such as Aurora Kinases A and B, CDKs 4 and 6, and PLK1. …”
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Determining the role of missense mutations in the POU domain of HNF1A that reduce the DNA-binding affinity: A computational approach
Published 2017“…Second, the sequence conservation and DNA-binding sites of the mutant positions were assessed; as HNF1A protein is a transcription factor. Finally, the biochemical properties of the biological system were validated using molecular dynamic simulations in Gromacs 4.6.3 package. …”
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Supramaximal-Exercise Training Improves Heart Rate Variability in Association With Reduced Catecholamine in Obese Adults
Published 2021“…In this study, 19 OB [22.9 (8.4) years; body mass index (BMI) 33.4 (1.4) kg/m2] and 18 NW [23.2 (4.4) years; BMI 23.3 (1.2) kg/m2] adults completed a 6-week SET intervention. …”
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Mitigating Cardiotoxicity of Dendrimers: Angiotensin-(1-7) via Its Mas Receptor Ameliorates PAMAM-Induced Cardiac Dysfunction in the Isolated Mammalian Heart
Published 2022“…Herein, we investigated (a) the effect of polyamidoamine (PAMAM) dendrimer generation (G7, G6, G5, G4 and G3) and surface chemistry (-NH2, -COOH and -OH) on cardiac function in mammalian hearts following ischemia-reperfusion (I/R) injury, and (b) determined if any PAMAM-induced cardiotoxicity could be mitigated by Angiotensin-(1-7) (Ang-(1-7), a cardioprotective agent. …”
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Correlating the rheological and magneto-optical properties of cobalt substituted magnetite ferrofluids (CoxFe1?xFe2O4) with theoretical studies
Published 2023“…Faraday rotation of CoxFe1?xFe2O4 ferrofluids is measured depending on the different concentrations of cobalt in applied magnetic field. …”
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Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants
Published 2017“…FindingsWe pooled 1479 studies that had measured the blood pressures of 19·1 million adults. Global age-standardised mean systolic blood pressure in 2015 was 127·0 mm Hg (95% credible interval 125·7–128·3) in men and 122·3 mm Hg (121·0–123·6) in women; age-standardised mean diastolic blood pressure was 78·7 mm Hg (77·9–79·5) for men and 76·7 mm Hg (75·9–77·6) for women. …”
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Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants
Published 2017“…FindingsWe pooled 1479 studies that had measured the blood pressures of 19·1 million adults. Global age-standardised mean systolic blood pressure in 2015 was 127·0 mm Hg (95% credible interval 125·7–128·3) in men and 122·3 mm Hg (121·0–123·6) in women; age-standardised mean diastolic blood pressure was 78·7 mm Hg (77·9–79·5) for men and 76·7 mm Hg (75·9–77·6) for women. …”
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MYD88, IRAK3 and Rheumatoid Arthritis pathogenesis: Analysis of differential gene expression in CD14 + monocytes and the inflammatory cytokine levels.
Published 2021“…Two molecular players act in the inflammation balance of the disease: MyD88 (Myeloid differentiation primary response 88) is related to TLR (Toll-like receptors) response and promotes the formation of myddosome complex resulting in increased inflammation; IRAK3 (Interleukin-1 receptor associated kinase 3) acts suppressing the myddosome complex thus decreasing inflammation. …”
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Allergenicity of roasted peanuts treated with a non-human digestive protease
Published 2015“…The maximum reductions of Ara h 1 and Ara h 2 levels were obtained following 3hour digestion with alcalase at concentrations of 4.54 and 6.05U/100g. …”
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Olive Leaves Extract and Oleuropein Improve Insulin Sensitivity in 3T3-L1 Cells and in High-Fat Diet-Treated Rats via PI3K/AkT Signaling Pathway
Published 2023“…In preadipocytes cells, EE 1/100 decreased cell viability and induced apoptosis. …”
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