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    The Cellular Interplay Between Na+/H+ Exchanger Isoform I and Osteopontin in Cardiac Hypertrophy by Abdelaziz, Iman Ahmed

    Published 2014
    “…Overexpression of NHE1 and OPN in cardiomyocytes significantly increased cell area (158.4±3.59% of control); this was significantly reduced in the presence of OPN-siRNA (68.5±0.24% vs. 190.9±8.66% NHE1-infected). Protein content and ANP mRNA expression were also significantly increased in NHE1-infected cardiomyocytes, however they were significantly abrogated in the presence of OPN-siRNA (87.8±12.58% vs. 136.8±11% NHE1-infected) and (64.6±19.9% vs. 247.7±30.81% NHE1-infected). …”
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