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Exendin-4 alleviates steatosis in an in vitro cell model by lowering FABP1 and FOXA1 expression via the Wnt/-catenin signaling pathway
Published 2022“…Additionally, after β-catenin silencing, OA treatment significantly increased the expression of nuclear transcription factors SREBP-1 and TCF4, whereas Ex-4 significantly decreased this upregulation. Our findings suggest that direct activation of GLP-1R by Ex-4 reduces OA-induced steatosis in HepG2 cells by reducing fatty acid uptake and transport via FABP1 downregulation.…”
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A clustering metaheuristic for large orienteering problems
Published 2022“…The metaheuristic aims to dramatically improve the computation time of a given Orienteering Problem algorithm without a significant decrease in the solution quality of that algorithm, especially for large Orienteering Problems. …”
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Genetic Deletion of DNAJB3 Using CRISPR-Cas9, Produced Discordant Phenotypes
Published 2023“…Three DNAJB3 knockout (KO) lines were generated (KO 30, 44 and 47), using CRISPR-Cas9. Male and female KO and WT mice were fed a HF diet (45% kcal fat) for 16 weeks. …”
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The new accounting standard IFRS 9 and its impact on how banks should provision for credit losses
Published 2019“…IFRS9 also can affect deal pricing under the new standard for risky customers may get higher price than normal customers. …”
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Genetic engineering to enhance microalgal-based produced water treatment with emphasis on CRISPR/Cas9: A review
Published 2023“…Bioremediation using microalgae has received increased interest as a method for produced water treatment for removing not only major contaminants such as nitrogen and phosphorus, but also heavy metals and hydrocarbons. …”
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A GRASP Approach for Solving Large-Scale Electric Bus Scheduling Problems
Published 2021“…The problem is modelled using a mixed integer program (MIP) in which the charging time of an EB is pertinent to the battery’s state-of-charge level. To be able to solve large problem instances corresponding to real-world applications of the model, a metaheuristic approach is investigated. …”
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Targeted Inactivation of Rin3 Increases Trabecular Bone Mass by Reducing Bone Resorption and Favouring Bone Formation
Published 2021“…Mean ± standard deviation values at the distal femur at 8 weeks were 9.0 ± 2.5 vs. 7.0 ± 1.5 (p = 0.002) and at 52 weeks were 15.8 ± 9.5 vs. 8.5 ± 4.2 (p = 0.002). …”
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Comparing WZB117-liposome Synthesis via Thin-film Hydration and Microfluidic Methods
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doctoralThesis -
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Flavin Adenine Dinucleotide (FAD) and Pyridoxal 5′-Phosphate (PLP) Bind to Sox9 and Alter the Expression of Key Pancreatic Progenitor Transcription Factors
Published 2022“…Pyridoxal 5′-phosphate (PLP), the active form of vitamin B6, also binds to Sox9 and results in a similar increase in pancreatic development markers. …”
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Parallel multi-voltage power minimization in VLSI circuits. (c2013)
Published 2013Get full text
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<i>Asterarcys quadricellulare</i> (Chlorophyceae) protects H9c2 cardiomyoblasts from H<sub>2</sub>O<sub>2</sub>-induced oxidative stress
Published 2022“…The protein expression of total caspase-3 was also examined to investigate whether the extract protects H9c2 cardimyoblasts from H2O2-induced apoptosis. …”
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Shear Strength Behaviors of Tire Shred-Dune Sand Admixtures
Published 2024Get full text
doctoralThesis
