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Protein arginine methyltransferase 5 (PRMT5) promotes survival of lymphoma cells via activation of WNT/B-catenin and AKT/GSK3B proliferative signaling
Published 2019“…In this report, we investigate the relationship between PRMT5 and WNT/B- CATENIN as well as AKT/GSK3B proliferative signaling in three different types of non-Hodgkin's lymphoma cell lines, clinical samples, and mouse primary lymphoma cells. …”
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Novel, selective EPO receptor ligands lacking erythropoietic activity reduce infarct size in acute myocardial infarction in rats
Published 2016“…Test compounds and positive controls for model validation (B-type natriuretic peptide, BNP or cyclosporine A, CsA) were administered iv. before the onset of reperfusion. …”
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Profiling of intestinal microbiota in patients infected with respiratory influenza a and b viruses
Published 2021“…Overall, infected patients experienced an increased abundance of Bacteroidetes and a corresponding decrease in Firmicutes. Differential abundance testing illustrated that differences in gut microbiota composition were influenza type-dependent, identifying ten differentially abun-dant operational taxonomic units (OTUs) between influenza A-and influenza B-infected patients. …”
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Nanoclay compatibilization of phase separated polysulfone/polyimide films for oxygen barrier
Published 2017“…Thermal decomposition (TGA) measurements of PSF/PI films showed a decrease in thermal stability upon adding C30B due to its surfactant modification, while film mechanical tensile modulus properties improved slightly by adding low concentration of C30B (~ 1 mass%), but higher nanoclay loading decreased tensile strength and elongation at break. …”
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Prevalence and Phylogenetic Analysis of Parvovirus (B19V) among Blood Donors with Different Nationalities Residing in Qatar
Published 2021“…Results: Only 1.4% (70/5026) of the samples had detectible B19V DNA in their blood. B19V DNA prevalence statistically decreased with age (p = 0.03). …”
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Pharmacoeconomic evaluation of voriconazole vs. liposomal amphotericin B in empiric treatment of invasive fungal infections in Turkey
Published 2013“…Univariate sensitivity analysis highlighted that increasing the duration of voriconazole by >1.2 days or decreasing LAmB by >1.0 days changes the result. Monte Carlo Simulation resulted in 69.4% of simulations favouring voriconazole per patient treated.Conclusion: There is a strong likelihood that voriconazole is economically more favourable than LAmB in the empiric treatment of IFI in Turkey.…”
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A vector quantization based k-NN approach for large-scale image classification
Published 2017“…The k-nearest-neighbour classifiers (k-NN) have been one of the simplest yet most effective approaches to instance based learning problem for image classification. …”
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In vitro evaluation of Neosetophomone B inducing apoptosis in cutaneous T cell lymphoma by targeting the FOXM1 signaling pathway
Published 2023“…Notably, higher expression levels of these genes showed reduced overall and progression-free survival in the CTCL patient cohort. FOXM1 and BUB1B expression exhibited a dose-dependent reduction in NSP-B-treated CTCL cells.FOXM1 silencing decreased cell viability and increased apoptosis via BUB1B downregulation. …”
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Design and analysis of PV fed high-voltage gain DC-DC converter using PI and NN controllers
Published 2022“…The converter's switching pulse can be adjusted by PI or NN. The entire system was designed in MATLAB/ Simulink tool.…”
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Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts.
Published 2020“…In an in-vitro cell model, these compounds decreased the insoluble phosphorylated α-syn and aggregation. …”
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Rhus coriaria suppresses angiogenesis, metastasis and tumor growth of breast cancer through inhibition of STAT3, NFκB and nitric oxide pathways
Published 2016“…Not only did Rhus coriaria decrease their adhesion to HUVECs and to lung microvascular endothelial (HMVEC-L) cells, but it also inhibited the transendothelial migration of MDA-MB-231 cells through TNF-α-activated HUVECs. …”
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Hyperhydration-induced decrease in urinary luteinizing hormone concentrations of Male athletes in doping control analysis
Published 2019“…A comparison of the measured LH values for both hyperhydration phases (Phase A: 4.24 � 5.60 IU/L and Phase B: 4.74 � 4.72 IU/L) with the baseline (''normal'') values showed significant differences (Phase A: p < .001 and Phase B: p < .001), suggesting the clear effect of urine dilution due to hyperhydration. …”
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Anti-Metastatic and Anti-Tumor Growth Effects of Origanum majorana on Highly Metastatic Human Breast Cancer Cells: Inhibition of NFκB Signaling and Reduction of Nitric Oxide Produc...
Published 2013“…Further investigation revealed that O. majorana suppresses the phosphorylation of IκB, downregulates the nuclear level of NFκB and reduces Nitric Oxide (NO) production in MDA-MB-231 cells. …”
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Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle
Published 2023“…We found both young and aged HSA-mUCP1 mice had decreased advanced glycation endproducts (AGEs) formed from MG, lysine-derived Nε(1-carboxyethyl)lysine (CEL) and arginine-derived hydroimidazolone, MG-H1, whereas protein glycation by glucose forming Nε-fructosyl-lysine (FL) was increased ca. 2-fold, compared to wildtype controls. …”
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Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle
Published 2023“…We found both young and aged HSA-mUCP1 mice had decreased advanced glycation endproducts (AGEs) formed from MG, lysine-derived Nε(1-carboxyethyl)lysine (CEL) and arginine-derived hydroimidazolone, MG-H1, whereas protein glycation by glucose forming Nε-fructosyl-lysine (FL) was increased ca. 2-fold, compared to wildtype controls. …”
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