Selective Targeting of <i>CTNNB1-</i>, <i>KRAS-</i> or <i>MYC-</i>Driven Cell Growth by Combinations of Existing Drugs by Joost C. M. Uitdehaag (540162)

“…The approach is based on curve shift analysis, which we demonstrate is a more robust method of determining synergy than combination matrix screening with Bliss-scoring. …”

Image_1_Traumatic Brain Injury-Induced Sex-Dependent Changes in Late-Onset Sensory Hypersensitivity and Glutamate Neurotransmission.TIF by Gokul Krishna (9207362)

“…Similar to our previous report, we found the glutamate clearance parameters were not influenced by FPI, while a sex-specific effect was evident with female rats showing a lower uptake rate constant both in S1BF and VPM and longer clearance time (in S1BF) in comparison to male rats. …”

Table5_Ursolic acid reduces oxidative stress injury to ameliorate experimental autoimmune myocarditis by activating Nrf2/HO-1 signaling pathway.XLSX by Yanan Fu (4422967)

“…Mechanistically, UA reduced myocardial injury by inhibiting oxidative stress (as demonstrated by a decrease of superoxide and normalization of pro- and antioxidant enzyme levels). …”

<b>Estimating the net benefit of street trees in </b><b>Greater Adelaide Metropolitan, Australia</b> by John Kandulu (4194325)

“…However, recent data show that in many cities, including around the Greater Adelaide Metropolitan area, there is a decrease in the quantity as well as quality of greenspace. …”

Image1_Evaluating the inhibitory effect of resveratrol on the multiplication of several Babesia species and Theileria equi on in vitro cultures, and Babesia microti in mice.pdf by Shimaa Abd El-Salam El-Sayed (13834724)

“…Reverse transcription PCR assay showed that such inhibitory activity might be attributed to resveratrol’s stimulatory effect on B. bovis KDAC3 (BbKADC3) as well as its inhibitory effect on BbKATS. RVT causes a significant decrease (P < 0.05) in cardiac troponin T (cTnT) levels in heart tissue of B. microti- infected mice, thereby indicating that RVT may play a part in reducing the cardiotoxic effects of AZM. …”

DataSheet1_Immune cell population and cytokine profiling suggest age dependent differences in the response to SARS-CoV-2 infection.PDF by Larraitz Aragon (14604653)

“…In this age range, an increased exhausted T cell response and a decrease of naïve T helper lymphocytes was found in patients, as well as a reduced concentration of the proinflammatory TNF, IL-1β and IL-8 cytokines. …”

Image_2_MaMYB4, an R2R3-MYB Repressor Transcription Factor, Negatively Regulates the Biosynthesis of Anthocyanin in Banana.JPEG by Gui-Ming Deng (4920463)

“…Consistent with the above results, metabolome results showed that there was a decrease in all three identified cyanidins and one delphinidin, the main anthocyanins that determine the color of banana leaves, whereas both transcriptome and reverse transcription–quantitative polymerase chain reaction analysis showed that many key anthocyanin synthesis structural genes and TF regulators were downregulated in MaMYB4 overexpressors. …”

Table1_Disordered Gut Microbiota in Colorectal Tumor-Bearing Mice Altered Serum Metabolome Related to Fufangchangtai.DOCX by Mengmeng Cai (12480588)

“…</p><p>Results: The tumor volume of mice showed no significant decrease after FFCT intervention. The levels of CD4⁺ and CD8⁺T lymphocytes showed a significant increase under the intervention of FFCT. …”

Image_1_The Ecological Limits of Poverty Alleviation in an African Forest-Agriculture Landscape.JPEG by Alexandra C. Morel (2825084)

“…Our findings suggest, that if all households adopted the optimal level of each of these management options, and in so doing had similar poverty profiles to those households already managing optimally, we would see the community-averaged probability: a child of a household misses school decrease from 47 to 31%, a household would be able to acquire assets increase from 40 to 59% and a household would have access to an adequate amount of food increase from 62 to 79%.…”

TGF-β Regulates DNA Methyltransferase Expression in Prostate Cancer, Correlates with Aggressive Capabilities, and Predicts Disease Recurrence by Qiang Zhang (45005)

“…Blockade of TGF-β signaling or ERK activation (p-ERK) was associated with a dramatic decrease in the expression of DNMT, which results in a coincident increase in the expression of TβRs. …”

Image1_Ursolic acid reduces oxidative stress injury to ameliorate experimental autoimmune myocarditis by activating Nrf2/HO-1 signaling pathway.TIF by Yanan Fu (4422967)

“…Mechanistically, UA reduced myocardial injury by inhibiting oxidative stress (as demonstrated by a decrease of superoxide and normalization of pro- and antioxidant enzyme levels). …”

Table2_Ursolic acid reduces oxidative stress injury to ameliorate experimental autoimmune myocarditis by activating Nrf2/HO-1 signaling pathway.XLSX by Yanan Fu (4422967)

“…Mechanistically, UA reduced myocardial injury by inhibiting oxidative stress (as demonstrated by a decrease of superoxide and normalization of pro- and antioxidant enzyme levels). …”

Table1_Benchmarking of ATAC Sequencing Data From BGI’s Low-Cost DNBSEQ-G400 Instrument for Identification of Open and Occupied Chromatin Regions.XLSX by Marina Naval-Sanchez (6497258)

“…However, DNBSEQ-G400 data contained a significantly higher number of small, sub-nucleosomal reads (>30% increase) and a reduced number of bi-nucleosomal reads (>75% decrease), which resulted in narrower peak bases and improved peak calling, enabling the identification of 4% more differentially accessible regions between PSCs and fibroblasts. …”

MiR-150-5p retards the progression of myocardial fibrosis by targeting <i>EGR1</i> by Jie Shen (31533)

“…Human MF cells were generated via <i>Trypanosoma cruzi</i> (<i>T. cruzi)</i> infection, a mouse model of MF was generated via angiotensin II. …”

Ethnic Related Selection for an <em>ADH</em> Class I Variant within East Asia by Hui Li (32376)

“…Previous studies have shown that the <em>ADH1B*47His</em> allele at one of the seven genes in humans is associated with a decrease in the risk of alcoholism and the core molecular region with this allele has been selected for in some East Asian populations. …”

Table_2_Description of the vaginal microbiota in nulliparous ewes during natural mating and pregnancy: preliminary signs of the male preputial microbiota modulation.DOCX by Marta Barba (383893)

“…Ewes that were diagnosed with pregnancy at Tpreg showed a decreased abundance of gram-negative bacteria such as Bacteroidales, Campylobacterales, and Enterobacteriales. …”

Epigenetic silencing of miR-203 in Kazakh patients with esophageal squamous cell carcinoma by MassARRAY spectrometry by Xiaobin Cui (553791)

“…Furthermore, miR-203 expression showed a nearly 4.5-fold decrease in ESCC than NETs (0.206 ± 0.336 vs. 0.908 ± 1.424, <i>P</i> < 0.001) and was significantly associated with lymph node metastasis <i>(P</i> = 0.012). …”

Table_2_Porphyromonas gingivalis Induces Increases in Branched-Chain Amino Acid Levels and Exacerbates Liver Injury Through livh/livk.docx by Leng Wu (5190419)

“…Additionally, livh deletion had no effect on bacterial growth, EPS production, invasion efficiency, and in vivo colonization, whereas the Δlivk strain showed a slight decrease in invasion efficiency and in vivo colonization. …”

Circular_0086414 induces SPARC like 1 (<i>SPARCL1</i>) production to inhibit esophageal cancer cell proliferation, invasion and glycolysis and induce cell apoptosis by sponging miR... by Qingfeng Jiang (9134096)

“…EC patients with low circ_0086414 expression had a poor prognosis. Increasing circ_0086414 expression led to decreased EC cell proliferation, invasion and glycolysis and increased cell apoptosis, accompanied by a decrease of N-cadherin expression and an increase of E-cadherin expression. …”

Data_Sheet_1_Probiotics Lactobacillus reuteri Abrogates Immune Checkpoint Blockade-Associated Colitis by Inhibiting Group 3 Innate Lymphoid Cells.docx by Tingting Wang (123983)

“…Mechanistically, the protective effect of L. reuteri was associated with a decrease in the distribution of group 3 innate lymphocytes (ILC3s) induced by ICB associated colitis. …”