DataSheet1_Evaluation of Kratom Opioid Derivatives as Potential Treatment Option for Alcohol Use Disorder.PDF by Anna M. Gutridge (9852364)

“…Yet, at 10 and 30 mg∙kg⁻¹ doses (i.p.), paynantheine did not counteract morphine CPP. 7-hydroxypaynantheine and 7-hydroxyspeciogynine displayed potency at δOR but limited µOR potency relative to 7-hydroxymitragynine in vitro, and dose-dependently decreased voluntary alcohol consumption in WT but not δOR in KO mice. 7-hydroxyspeciogynine has a maximally tolerated dose of at least 10 mg∙kg⁻¹ (s.c.) at which it did not produce significant CPP neither alter general locomotion nor induce noticeable seizures.…”

Effect of Tie2 knockout on the expression of members of the Ang/Tie pathway in organs of <i>Tie2</i> knockout mice. by Peter J. Zwiers (7510744)

“…<p>Expression of members of the Angiopoietin/Tie system was determined by RT-qPCR. (<b>A</b>) <i>Tie1</i> expression. Percent decrease (downward arrow) of <i>Tie1</i> mRNA in <i>Tie2</i>^<i>ΔE9</i> knockout mice compared to <i>Tie2</i>^{<i>fl/fl/Cre-</i>} control mice are indicated under the X-axis. …”

S5 File - by John N. Staffurth (20636565)

“…<div><p>To undertake a mixed-methodology implementation study to improve the well-being of men with gastrointestinal late effects following radical radiotherapy for prostate cancer. …”

Evolutionary Search and Theoretical Study of Silicene Grain Boundaries’ Mechanical Properties by Jianan Zhang (786459)

“…Twenty-one GBs with the lowest energy were validated by density functional theory (DFT), a majority of which were previously unreported to our best knowledge. …”

DataSheet1_Revealing historical observations and future projections of precipitation over Northwest China based on dynamic downscaled CMIP6 simulations.doc by Xianyu Yang (775475)

“…Future precipitation projections suggest significant decreases of precipitation across the southern and eastern NW, with a stronger reduction magnitude in summer. …”

Table_2_Single-cell RNA sequencing analysis of lung cells in COVID-19 patients with diabetes, hypertension, and comorbid diabetes-hypertension.xlsx by Xin Zhang (35492)

“…</p>Results<p>The single-cell meta-analysis of lung samples from SARS-CoV-2-infected individuals with diabetes, hypertension, and hypertension-diabetes comorbidity revealed an upregulation of fibroblast subpopulations in these disease conditions associated with a predictive decrease in lung function. To further investigate the response of fibroblasts to therapeutic targets in hypertension and diabetes, we analyzed 35 upregulated targets in both diabetes and hypertension. …”

Experimental device set up. by Koki Ebina (14046862)

“…<div><p>This study developed and validated a surgical instrument motion measurement system for skill evaluation during practical laparoscopic surgery training. …”

Image_2_Differential Root Exudation and Architecture for Improved Growth of Wheat Mediated by Phosphate Solubilizing Bacteria.jpg by Mahreen Yahya (5778458)

“…Seven isolates were the efficient P solubilizers based on in vitro P-solubilizing activity (233-365 μg ml^–1) with a concomitant decrease in pH (up to 3.5) by the production of organic acids, predominantly acetic acid (∼182 μg ml^–1) and gluconic acid (∼117 μg ml^–1). …”

All-trans retinoic acid suppresses the angiopoietin-Tie2 pathway and inhibits angiogenesis and metastasis in esophageal squamous cell carcinoma by Na Li (6550)

“…ATRA plus fluorouracil treatment reduced the viability more strongly than either drug alone, indicating an additive effect. Moreover, ATRA decreased EC1 migration by 87%. Furthermore, ATRA treatment led to a marked decrease of the transcript levels of Ang-1, Ang-2, Tie-2, VEGF, and VEGF receptors, as assessed by real-time RT-PCR. …”

DataSheet_1_CT-based deep learning radiomics signature for the preoperative prediction of the muscle-invasive status of bladder cancer.docx by Weitian Chen (5200715)

“…Objectives<p>Although the preoperative assessment of whether a bladder cancer (BCa) indicates muscular invasion is crucial for adequate treatment, there currently exist some challenges involved in preoperative diagnosis of BCa with muscular invasion. …”

Image_3_Targeting the BMP Pathway in Prostate Cancer Induced Bone Disease.tif by Desiree M. Straign (8678604)

“…We next proceeded to test BMP inhibition in an injury model of established bone metastasis via intratibial injection of the MYC-CaP mouse prostate cell line into FVBN syngeneic mice. DMH1 treated mice had a modest decrease in trabecular bone and reduced lymphocytes in circulation without affecting tumor growth. …”

Presentation_1_Nitrogen Deprivation-Induced Production of Volatile Organic Compounds in the Arachidonic-Acid-Accumulating Microalga Lobosphaera incisa Underpins Their Role as ROS S... by Puja Kumari (3838381)

“…Transcriptomics data supported the VOC patterns and revealed the upregulation of genes involved in fatty aldehyde, fatty alcohol, and ketone synthesis, including lipoxygenase, thioesterase, and fatty acyl CoA reductase, along with a decrease in the expression of genes putatively implicated in alkene biosynthesis. …”

Data_Sheet_1_The Ecological Limits of Poverty Alleviation in an African Forest-Agriculture Landscape.pdf by Alexandra C. Morel (2825084)

“…Our findings suggest, that if all households adopted the optimal level of each of these management options, and in so doing had similar poverty profiles to those households already managing optimally, we would see the community-averaged probability: a child of a household misses school decrease from 47 to 31%, a household would be able to acquire assets increase from 40 to 59% and a household would have access to an adequate amount of food increase from 62 to 79%.…”

Image_1_Differential physiological and production responses of C3 and C4 crops to climate factor interactions.jpg by Emmanuel Opoku (11195298)

“…However, the negative effect of drought is amplified by the effect of high temperature, similarly for biomass and photosynthetic rates. Sorghum also showed a mitigating effect of elevated CO₂ concentration on the negative drought impact, particularly in reducing the decrease of relative water content in leaves. …”

Table_5_Occurrence and distribution of Salmonella serovars in carcasses and foods in southern Italy: Eleven-year monitoring (2011–2021).DOCX by Maria Francesca Peruzy (13914246)

“…Infantis and monophasic S. Typhimurium and a decrease of S. Typhimurium were recorded (p < 0.05). …”

Image_2_Anticancer Effects of Wild Mountain Mentha longifolia Extract in Adrenocortical Tumor Cell Models.jpeg by Felicia Patti (8429184)

“…Recently, its antiproliferative role has been suggested in a small number of tumor cell models, but no data are available on adrenocortical carcinoma, a malignancy with a survival rate at 5 years of 20%–30% which frequently metastasize. …”

Data_Sheet_1_Human Cytomegalovirus Immediate Early Protein 2 Protein Causes Cognitive Disorder by Damaging Synaptic Plasticity in Human Cytomegalovirus-UL122-Tg Mice.doc by Zhifei Wang (1622731)

“…In the Morris water maze, cognitive impairment was more pronounced in 12-month-old UL122 mice than in 6-month-old ones. At the same time, a decrease of the density of dendritic spines and branches in the hippocampal neurons of 12-month-old mice was observed. …”

Image1_Benchmarking of ATAC Sequencing Data From BGI’s Low-Cost DNBSEQ-G400 Instrument for Identification of Open and Occupied Chromatin Regions.JPEG by Marina Naval-Sanchez (6497258)

“…However, DNBSEQ-G400 data contained a significantly higher number of small, sub-nucleosomal reads (>30% increase) and a reduced number of bi-nucleosomal reads (>75% decrease), which resulted in narrower peak bases and improved peak calling, enabling the identification of 4% more differentially accessible regions between PSCs and fibroblasts. …”

Data_Sheet_1_Removal of metals and emergent contaminants from liquid digestates in constructed wetlands for agricultural reuse.DOCX by Pau Porras-Socias (18773899)

“…The treatment also removed oxytetracycline, sulfadiazine and ofloxacin over 99%, and decreased intl1, tetA, tetW, sul1 and qnrS gene copies. …”

Table_2_Widely targeted metabolomics and SPME-GC-MS analysis revealed the quality characteristics of non-volatile/volatile compounds in Zheng’an Bai tea.xls by Li Liu (75607)

“…Meanwhile, 97 kinds of volatile metabolites were detected in these samples, most of which had a higher content in the fresh leaves. Moderate spreading is conducive to the release of the aroma of tea leaves, but fixation causes a sharp decrease in the content of most volatile metabolites. …”