Data Sheet 1_Phase 2 trial (NCI-COTC030) of adjuvant inhaled recombinant human IL-15 combined with amputation and adjuvant chemotherapy in dogs with appendicular osteosarcoma.pdf by Robert B. Rebhun (8479020)

“…We evaluated inhaled IL-15 combined with amputation and chemotherapy for localized canine OSA eligible for treatment with curative intent.</p>Methods<p>In a multicenter COTC phase-II-trial for dogs with limb OSA, we hypothesized 2 weeks of inhaled rhIL-15 after amputation and prior to chemotherapy would reduce the risk of metastatic failure at the completion of chemotherapy from a historical rate of 40% to 20%. …”

Construction of Recombinant HVT Expressing PmpD, and Immunological Evaluation against <i>Chlamydia psittaci</i> and Marek’s Disease Virus by Shanshan Liu (315561)

“…<i>psittaci</i> CB7 strain, a significant decrease in respiratory distress, lesions and <i>Chlamydia</i> load was found in the rHVT-<i>pmpD</i>-N-vaccinated group compared to the parental HVT. …”

Effect of MMA on luciferase reporter activity in HepG2 cells transfected with vectors containing <i>Gsta1</i>-ARE. by Ai Orimoto (389831)

“…<p>(A) Structures of reporter constructs. The vector pGL4.10-<i>Gsta1</i>pro990 contains 5′-flanking region (-990 to +46; the 41-bp of ARE region is located -729 to -689) immediately upstream of the synthetic firefly luciferase reporter gene (<i>luc2</i>), which was previously constructed <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0058907#pone.0058907-Hattori1" target="_blank">[16]</a>. …”

Table1_Shale Heavy Metal Isotope Records of Low Environmental O2 Between Two Archean Oxidation Events.XLSX by Chadlin M. Ostrander (12460062)

“…Sylvia formations preserved in drill core ABDP9). We find a progressive decrease in bulk-shale Fe isotope compositions moving up core (as low as δ⁵⁶Fe = –0.78 ± 0.08‰; 2SD) accompanied by invariant authigenic Tl isotope compositions (average ε²⁰⁵Tl_A = –2.0 ± 0.6; 2SD) and bulk-shale U isotope compositions (average δ²³⁸U = –0.30 ± 0.05‰; 2SD) that are both not appreciably different from crustal rocks or bulk silicate Earth. …”

Proportion of dead and alive neonates. by Sujan Kumar Naha (20577028)

“…Among them, 23.07% received a single dose, and 22.82% took adequate doses (receiving more than two doses) and adhered to WHO guidelines. …”

Table_2_Extremely Preterm Infant Admissions Within the SafeBoosC-III Consortium During the COVID-19 Lockdown.XLSX by Marie Isabel Rasmussen (11110416)

“…There were no statistically significant differences within individual geographic regions and no significant association between the level of lockdown restrictions and difference in the number of EP infant admissions. A post-hoc analysis based on data from the 46 NICUs found a decrease of 10.3%in the total number of NICU admissions (n = 7,499 in 2020 vs. n = 8,362 in 2019).…”

Image_1_Indomethacin Treatment Post-irradiation Improves Mouse Parotid Salivary Gland Function via Modulation of Prostaglandin E2 Signaling.TIFF by Kristy E. Gilman (11163543)

“…Combined, these data suggest a mechanism whereby irradiation-induced PGE₂ signaling to JNK blocks critical steps in saliva secretion manifested by a decrease in the quality (diminished amylase) and quantity (loss of calcium channel activity) of saliva, that can be restored with indomethacin. …”

Image_1_Indomethacin Treatment Post-irradiation Improves Mouse Parotid Salivary Gland Function via Modulation of Prostaglandin E2 Signaling.TIFF by Kristy E. Gilman (11163543)

“…Combined, these data suggest a mechanism whereby irradiation-induced PGE₂ signaling to JNK blocks critical steps in saliva secretion manifested by a decrease in the quality (diminished amylase) and quantity (loss of calcium channel activity) of saliva, that can be restored with indomethacin. …”

Image_3_Indomethacin Treatment Post-irradiation Improves Mouse Parotid Salivary Gland Function via Modulation of Prostaglandin E2 Signaling.TIFF by Kristy E. Gilman (11163543)

“…Combined, these data suggest a mechanism whereby irradiation-induced PGE₂ signaling to JNK blocks critical steps in saliva secretion manifested by a decrease in the quality (diminished amylase) and quantity (loss of calcium channel activity) of saliva, that can be restored with indomethacin. …”

Image_3_Indomethacin Treatment Post-irradiation Improves Mouse Parotid Salivary Gland Function via Modulation of Prostaglandin E2 Signaling.TIFF by Kristy E. Gilman (11163543)

“…Combined, these data suggest a mechanism whereby irradiation-induced PGE₂ signaling to JNK blocks critical steps in saliva secretion manifested by a decrease in the quality (diminished amylase) and quantity (loss of calcium channel activity) of saliva, that can be restored with indomethacin. …”

Chronic High Fructose Intake Reduces Serum 1,25 (OH)₂D₃ Levels in Calcium-Sufficient Rodents by Veronique Douard (549533)

“…Replacing glucose with fructose prevented these increases in Ca²⁺ transporter, CYP27B1, and 1,25(OH)₂D₃ levels induced by a low Ca²⁺ diet. In adult mice fed for three mo a normal Ca²⁺ diet, renal expression of CYP27B1 and of CYP24A1 (24-hydroxylase) decreased and increased, respectively, when the carbohydrate source was fructose instead of glucose or starch. …”

DataSheet_1_Differential regulatory T cell signature after recovery from mild COVID-19.pdf by Pedro Henrique de Sousa Palmeira (14758156)

“…Interestingly, Pool Spike CoV-2 elicited a decrease in Treg IL-17⁺ frequency in the Severe Recovered group. …”

Factor associated with neonatal mortality. by Sujan Kumar Naha (20577028)

“…Among them, 23.07% received a single dose, and 22.82% took adequate doses (receiving more than two doses) and adhered to WHO guidelines. …”

Table1_Neuroprotective potency of mangiferin against 3-nitropropionic acid induced Huntington’s disease-like symptoms in rats: possible antioxidant and anti-inflammatory mechanisms... by Pei Teng Lum (16537509)

“…Further, a significant depletion in brain malondialdehyde (MDA) level, an increase in reduced glutathione (GSH) level, succinate dehydrogenase (SDH), superoxide dismutase (SOD) and catalase (CAT) activities, and a decrease in tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β) and interleukin-6 (IL-6) levels were observed in mangiferin treated groups. …”

Image_2_Indomethacin Treatment Post-irradiation Improves Mouse Parotid Salivary Gland Function via Modulation of Prostaglandin E2 Signaling.TIFF by Kristy E. Gilman (11163543)

“…Combined, these data suggest a mechanism whereby irradiation-induced PGE₂ signaling to JNK blocks critical steps in saliva secretion manifested by a decrease in the quality (diminished amylase) and quantity (loss of calcium channel activity) of saliva, that can be restored with indomethacin. …”

<b>IER3IP1 mutations cause neonatal diabetes due to impaired proinsulin trafficking</b> by Hossam Montaser (10017443)

“…While these mutant stem cell lines differentiated normally into definitive endoderm and pancreatic progenitors, we observed that IER3IP1-KO stem cell derived-islets (SC-islets) presented a significant decrease in beta cell numbers and elevated ER stress. …”

Screen candidates modify the expression of RAS/MAPK components. by Dariel Ashton-Beaucage (538989)

“…(D) Also in agreement with the qPCR data, a specific decrease in PTP-ER levels was observed upon depletion of <i>CG4936</i>.…”

PRDM9 binds in vitro to meiotic recombination hotspots. by Corinne Grey (200646)

“…The amount of signal due to binding of each probe to PRDM9^wm7 is shown (with standard error), relative to <i>Psmb9^TC</i>. The decrease of binding to the double mutant probe <i>Psmb9</i>^CT (0.07% binding relative to <i>Psmb9</i>^TC) is consistent with a cumulative effect of each single mutant (0.36% and 0.14% binding relative to <i>Psmb9</i>^TC) suggesting their effects are independent. …”

Differentially methylated regions interrogated for metastable epialleles associate with offspring adiposity by Stephanie W Waldrop (19653383)

“…</p> <p>DNAm of MEs has been suggested to play a role in energy balance and has previously been associated with obesity in adult and pediatric populations.…”

Data_Sheet_1_Fatigue Induced by Repeated Changes of Direction in Élite Female Football (Soccer) Players: Impact on Lower Limb Biomechanics and Implications for ACL Injury Preventio... by Matteo Zago (5721068)

“…Measures of exercise internal load were: peak post-exercise blood lactate concentration, heart rate (HR) and perceived exertion. Continuous linear correlations between kinematics/kinetics waveforms (during the ground contact phase of the pivoting limb) and the number of consecutive CoD were computed during the exercise using a Statistical Parametric Mapping (SPM) approach.…”