CpG ODN D35 improves the response to abbreviated low-dose pentavalent antimonial treatment in non-human primate model of cutaneous leishmaniasis by Seth G Thacker (8582487)

“…Here we explored whether the addition of a single dose of immunomodulating CpG ODN D35 augments the efficacy of a short-course, low-dose pentavalent antimonial treatment regimen. …”

Table_5_Alterations of Gut Microbiome and Metabolite Profiling in Mice Infected by Schistosoma japonicum.XLSX by Yue Hu (201714)

“…<p>Schistosoma japonicum (S. japonicum) is one of the etiological agents of schistosomiasis, a widespread zoonotic parasitic disease. However, the mechanism of the balanced co-existence between the host immune system and S. japonicum as well as their complex interaction remains unclear. …”

Effect of statin on progression of symptomatic basilar artery stenosis and subsequent ischemic stroke by Kyu Sun Yum (4059748)

“…</p><p>Results</p><p>Of the 153 patients with symptomatic BAS, 114 (74.5%) were treated with a statin after experiencing a stroke. Statin therapy significantly prevented the progression of symptomatic BAS (7.0% vs 28.2%) and induced regression (22.8% vs 15.4%) compared to non-statin users (p = 0.002). …”

Table_1_Characteristics of cardiac involvement in immune-mediated necrotizing myopathy.docx by Mengyang Liu (3074763)

“…Cardiac ultrasound was performed in 14 patients and 3 showed pericardial effusion (21.4%); Decreased left ventricular ejection fraction and atrial enlargement were 2 each; 8 showed a decrease in left ventricular diastolic function (57.1%). …”

Supplementary Material for: Reduction of Caloric Intake Might Override the Prosteatotic Effects of the <b><i>PNPLA3</i></b> p.I148M and <b><i>TM6SF2</i></b> p.E167K Variants in Pat... by Krawczyk M. (4157323)

“…Overall, 88 patients completed the intervention, which led to a significant decrease of steatosis, ALT activities, body mass index, hip and waist circumferences, and waist-hip ratio (all p < 0.0001). …”

Table1_Tectonic and Climatic Control on Quaternary Exhumation in the Eastern Pamir Domes, Western China: Insights From Geomorphic Approaches.XLSX by Kai Cao (252808)

“…We first evaluated the validity of various indices and chose three active tectonic-sensitive indices to establish a newly-integrated parameter (Iat) that is used to measure relative intensities of tectonic activity in active orogens. …”

DataSheet1.pdf by Vincent Portero (518206)

“…Using computer simulations employing a multicellular in silico model, we furthermore demonstrate that the experimentally observed increase in K_V4.3 current and concurrent decrease in Na_V1.5 current may result in a loss of conduction, underlining the potential functional relevance of our findings. …”

Table11_BuShen HuoXue decoction improves fertility through intestinal hsp-16.2-mediated heat-shock signaling pathway in Caenorhabditis elegans.DOCX by Kanglu Wu (16009853)

“…</p><p>Methods: Bisphenol A (BPA, 175 μg/mL) was used to establish a fertility-defective C. elegans model. …”

Data_Sheet_1_Sleep in 21-Day Dry Immersion. Are Cardiovascular Adjustments Rapid Eye Movement Sleep-Dependent?.docx by Evgeny Yu. Bersenev (11605863)

“…<p>Introduction: A decrease in sleep quality and duration during space missions has repeatedly been reported. …”

Data_Sheet_3_Stochastic partial budget analysis of strategies to reduce the prevalence of lung lesions in finishing pigs at slaughter.pdf by Josefine Jerlström (13957386)

“…A partial budget analysis was then performed in which the baseline farm was compared with two hypothetical strategies aimed at reducing the occurrence and spread of respiratory diseases during pig production: (S1) avoiding mixing of litters after weaning and (S2) keeping purchased pregnant gilts separated from sows during gestation, farrowing and lactation. …”

Image 4_Wip1 inhibitor CCT007093 alleviates immune exhaustion of lymphocytes via p65 NF-κB and YY1 in chronic hepatitis B virus infection in mice.tif by Yu-Syuan You (21288113)

“…</p>Methods<p>We focused on CCT007093, a Wip1 inhibitor, screened for its distinctive capacity to simultaneously decrease PD-1 and FcγRIIB expression in B cells.…”

Table 1_High-dose medium-term HMB supplementation did not trigger body composition changes in trained and untrained males under usual conditions or high-intensity functional exerci... by Krzysztof Durkalec-Michalski (4691311)

“…Nevertheless, there was an impact (p < 0.05) from training status (but not HMB/PLA) on FM (kg; slight increases in UTR) and TBW (slight decreases in UTR).</p>Discussion<p>The individually adjusted high HMB dose did not change body mass and composition in trained or untrained individuals during a three-week exclusive supplementation or three-week supplementation in combination with additional HIFT stimuli. …”

Cytotoxic activity. by Xiaopei Lin (8993858)

“…<div><p>Necrotizing enterocolitis (NEC) is a severe intestinal disease of the newborn infants, associated with high morbidity and mortality. …”

Synthesis and X‑ray Crystallography of [Mg(H₂O)₆][AnO₂(C₂H₅COO)₃]₂ (An = U, Np, or Pu) by Viktor N. Serezhkin (1591696)

“…Actinide contraction in the series of U­(VI)–Np­(VI)–Pu­(VI) in compounds <b>I</b>–<b>III</b> is reflected in a decrease in the mean AnO bond lengths and in the volume and sphericity degree of Voronoi–Dirichlet polyhedra of An atoms.…”

Data Sheet 1_Effects of Long-term low-dose intermittent rapamycin administration on glucose metabolism and immune system of SAMP8 and SAMR1 mice.docx by Luiz Adriano Damasceno Queiroz (18116671)

“…In SAMR1 mice, RAPA administration led to a decrease in CD3⁺ thymocytes and splenic lymphoproliferative capacity, while also enhanced mitochondrial performance. …”

Table1_BuShen HuoXue decoction improves fertility through intestinal hsp-16.2-mediated heat-shock signaling pathway in Caenorhabditis elegans.DOC by Kanglu Wu (16009853)

“…</p><p>Methods: Bisphenol A (BPA, 175 μg/mL) was used to establish a fertility-defective C. elegans model. …”

Mechanistic framework predicts drug-class specific utility of antiretrovirals for HIV prophylaxis by Sulav Duwal (152805)

“…However, poor translatability of animal- and <i>ex vivo</i>/<i>in vitro</i> experiments, and the necessity to conduct long-term (several years) human trials involving considerable sample sizes (N>1000 individuals) are major obstacles to rationalize drug-candidate selection. We developed a prophylaxis modelling tool that mechanistically considers the mode-of-action of all available drugs. …”

Chronic Intermittent Hypoxia Is Independently Associated with Reduced Postoperative Opioid Consumption in Bariatric Patients Suffering from Sleep-Disordered Breathing by Alparslan Turan (2336)

“…Percentage of total sleep time spent at SaO₂ < 90% was inversely associated with total postoperative opioid consumption; a 5-%- absolute increase in the former would relatively decrease median opioid consumption by 16% (98.75% CI: 2% to 28%, P = 0.006). …”

Downregulation of COP9 signalosome subunits differentially affects the CSN complex and target protein stability-5 by Andreas Peth (85734)

“…Whereas the anti-CSN5 antibody revealed a reduction to 23% as compared to the control, there was no decrease of the CSN complex observed with the anti-CSN8 antibody. …”

Table_2_Endurance Training Counteracts the High-Fat Diet-Induced Profiling Changes of ω-3 Polyunsaturated Fatty Acids in Skeletal Muscle of Middle-Aged Rats.pdf by Ting Li (117885)

“…</p>Results<p>Rats fed a high-fat diet exhibited decreased overall amount of ω-3 PUFAs in soleus muscle, while endurance training preserved the total amount of ω-3 PUFAs. …”