Image_6_Nujiangexanthone A Inhibits Hepatocellular Carcinoma Metastasis via Down Regulation of Cofilin 1.TIF by Li Zhang (8200)

“…Here, we found that CFL1 was up regulated in human HCC and significantly associated with both overall survival and disease-free survival in HCC patients. Nujiangexanthone A (NJXA), the caged xanthones, isolated from gamboge plants decreased the expression of CFL1, which also inhibited the migration, invasion and metastasis of HCC cells in vitro and in vivo. …”

Image_2_Nujiangexanthone A Inhibits Hepatocellular Carcinoma Metastasis via Down Regulation of Cofilin 1.TIF by Li Zhang (8200)

“…Here, we found that CFL1 was up regulated in human HCC and significantly associated with both overall survival and disease-free survival in HCC patients. Nujiangexanthone A (NJXA), the caged xanthones, isolated from gamboge plants decreased the expression of CFL1, which also inhibited the migration, invasion and metastasis of HCC cells in vitro and in vivo. …”

Protective effect of phosphoenolpyruvate carboxykinase 1 on inflammation and fibrotic progression of IgA nephropathy by Ya-yin Tan (21448519)

“…In experiments with SV40-transformed mouse glomerular mesangial cells (MCs), PCK1 and PPARγ protein expression levels were significantly decreased in polymeric IgA1 (pIgA1)-stimulated MCs, which contrasts with the increased expression of inflammatory and fibrotic factors. …”

Global glomerulosclerosis proportions predict nephropathy progression in IgA nephropathy: a multicenter retrospective analysis with propensity score matching by Wenli Zou (1643875)

“…Additionally, the multivariate Cox regression models identified higher proteinuria, decreased eGFR, higher score of tubular atrophy/interstitial fibrosis (T), higher GS proportions as independent prognostic factors for poor kidney outcomes, and corticosteroids therapy was a protective indicator of kidney outcomes. …”

EloA promotes HEL polyploidization upon PMA stimulation through enhanced ERK1/2 activity by Lanyue Hu (10942130)

“…The phosphorylation activity of ERK1/2 decreased upon the EloA inhibition, and the polyploidization process of HEL was hindered when ERK1/2 phosphorylation was inhibited by PD0325901 or SCH772984. …”

Identification of a novel nonsense mutation in α-galactosidase A that causes Fabry disease in a Chinese family by Yushi Peng (18783276)

“…<p>Fabry disease, a lysosomal storage disease, is an uncommon X-linked recessive genetic disorder stemming from abnormalities in the alpha-galactosidase gene (<i>GLA</i>) that codes human alpha-Galactosidase A (α-Gal A). …”

Image_1_Deficiency of G9a Inhibits Cell Proliferation and Activates Autophagy via Transcriptionally Regulating c-Myc Expression in Glioblastoma.TIF by Xiao Xue Ke (9698522)

“…Besides, knockdown or inhibition of G9a led to a cell cycle arrest in G2 phase, as well as decreased the expression of CDK1, CDK2, Cyclin A2, and Cyclin B1, while it induced the activation of autophagy. …”

Reprogramming of m⁶A epitranscriptome is crucial for shaping of transcriptome and proteome in response to hypoxia by Yan-Jie Wang (793358)

“…Here, we reported that total m⁶A level of mRNAs was decreased during hypoxia, which might be mediated by the induction of m⁶A eraser, ALKBH5. …”

Food Insecurity among Homeless Adults with Mental Illness by Milad Parpouchi (3149874)

“…Younger age, needing health care but not receiving it, poorer subjective mental health, having spent over $500 for drugs and alcohol in the past month, HIV/AIDS and having gone to a drop-in centre, community meal centre or program/food bank each increased odds of food insecurity, while less than high school completion and heart disease each decreased odds of food insecurity. …”

Data_Sheet_1_TUBA4A downregulation as observed in ALS post-mortem motor cortex causes ALS-related abnormalities in zebrafish.PDF by Evelien Van Schoor (8069198)

“…To investigate whether a decreased TUBA4A expression could be a driving factor in ALS pathogenesis, we assessed whether TUBA4A knockdown in zebrafish could recapitulate an ALS-like phenotype. …”

Indoxyl sulfate altered differentiation marker expression in mouse podocytes. by Osamu Ichii (339354)

“…<p>The size of differentiated mouse podocytes decreased with indoxyl sulfate compared to dimethyl sulfoxide (DMSO) control; n = 3, mean ± SD (<b>a</b>). * denotes significant differences between the DMSO and indoxyl sulfate groups (<i>P</i><0.05). …”

Data_Sheet_1_TUBA4A downregulation as observed in ALS post-mortem motor cortex causes ALS-related abnormalities in zebrafish.PDF by Evelien Van Schoor (8069198)

“…To investigate whether a decreased TUBA4A expression could be a driving factor in ALS pathogenesis, we assessed whether TUBA4A knockdown in zebrafish could recapitulate an ALS-like phenotype. …”

Growth and weight deficits in <i>cycG</i>^<i>HR7</i> mutant animals. by Patrick Fischer (783820)

“…Both, loss of CycG (<i>cycG</i>^<i>HR7</i>) and ubiquitous overexpression of CycG (<i>da</i>-Gal4::UAS-<i>CycG</i>) result in a significant weight reduction. However, in the combination, the weight deficit is significantly ameliorated and not further decreased, reflecting a rescue of CycG loss. …”

The Effect of Discontinuing Continuous Glucose Monitoring in Adults with Type 2 Diabetes Treated with Basal Insulin by Grazia Aleppo (8550433)

“…</p> <p><b>Conclusions: </b>In adults with type 2 diabetes treated with basal insulin who had been using real-time CGM for 8 months, discontinuing CGM resulted in a loss of about half of the initial gain in TIR that had been achieved during CGM use.…”

Prediction of Complex Human Traits Using the Genomic Best Linear Unbiased Predictor by Gustavo de los Campos (147991)

“…Evidence suggests that PA can be improved using Whole-Genome Regression (WGR) models where phenotypes are regressed on hundreds of thousands of variants simultaneously. The Genomic Best Linear Unbiased Prediction (G-BLUP, a ridge-regression type method) is a commonly used WGR method and has shown good predictive performance when applied to plant and animal breeding populations. …”

Long non-coding RNA PMS2L2 is down-regulated in osteoarthritis and inhibits chondrocyte proliferation by up-regulating miR-34a by Fei Yang (46361)

“…In <i>in vitro</i> studies, it was seen that endotoxin treatment of chondrocytes led to decreased PMS2L2 expression. It was found that PMS2L2 over-expression caused increased miR-34a expression in OA patient chondrocytes but not in cells from healthy controls. …”

Inhibition of the RhoA/Rho-associated, coiled-coil-containing protein kinase-1 pathway is involved in the therapeutic effects of simvastatin on pulmonary arterial hypertension by Wei-Hua Liu (4751559)

“…The effects of simvastatin were mediated by inhibition of RhoA/ROCK1. Simvastatin decreased RhoA/ROCK1 overexpression by inhibition of mevalonate, FPP, and GGPP synthesis.…”

Image3_RETRACTED: Effect of histone deacetylase inhibitors trichostatin A and valproic acid on hair cell regeneration in zebrafish lateral line neuromasts.JPEG by Yingzi He (12259307)

“…Additionally, BrdU immunostaining and western blot analysis showed that TSA or VPA treatment caused a significant decrease in the percentage of S-phase cells and induced p21^Cip1 and p27^Kip1 expression, both of which are likely to explain the decrease in the amount of newly regenerated hair cells in treated embryos. …”

Image1_RETRACTED: Effect of histone deacetylase inhibitors trichostatin A and valproic acid on hair cell regeneration in zebrafish lateral line neuromasts.JPEG by Yingzi He (12259307)

“…Additionally, BrdU immunostaining and western blot analysis showed that TSA or VPA treatment caused a significant decrease in the percentage of S-phase cells and induced p21^Cip1 and p27^Kip1 expression, both of which are likely to explain the decrease in the amount of newly regenerated hair cells in treated embryos. …”

Image2_RETRACTED: Effect of histone deacetylase inhibitors trichostatin A and valproic acid on hair cell regeneration in zebrafish lateral line neuromasts.JPEG by Yingzi He (12259307)

“…Additionally, BrdU immunostaining and western blot analysis showed that TSA or VPA treatment caused a significant decrease in the percentage of S-phase cells and induced p21^Cip1 and p27^Kip1 expression, both of which are likely to explain the decrease in the amount of newly regenerated hair cells in treated embryos. …”