DataSheet_1_Identifying hub genes in response to ustekinumab and the impact of ustekinumab treatment on fibrosis in Crohn’s disease.zip by Ying Xu (9172)

“…IL18, the ligand of IL18R1, was also found to have lower expression in the blood samples from responders vs. non-responders. (2) GSE112366 revealed a significant decrease in fibrosis-related module genes (COL4A1, TUBB6, IFITM2, SERPING1, DRAM1, NAMPT, MMP1, ZEB2, ICAM1, PFKFB3, and ACTA2) and fibrosis-related pathways (ECM–receptor interaction and PI3K-AKT pathways) after ustekinumab treatment.…”

Image3_Neuronal nitric oxide synthase required for erythropoietin modulation of heart function in mice.pdf by Jeeyoung Lee (2638744)

“…</p><p>Results: ΔEPORE mice showed a decrease in the left ventricular outflow tract (LVOT) peak velocity, ejection fraction, and fractional shortening, showing that endogenous non-erythroid EPO response is protective for heart function. …”

Data_Sheet_1_The role of immune suppression in COVID-19 hospitalization: clinical and epidemiological trends over three years of SARS-CoV-2 epidemic.PDF by Marta Canuti (336637)

“…This change coincided with an increase in the proportions of older patients and patients with co-morbidities and with a decrease in the proportion of patients with severe outcomes. …”

Table1_Neuronal nitric oxide synthase required for erythropoietin modulation of heart function in mice.docx by Jeeyoung Lee (2638744)

“…</p><p>Results: ΔEPORE mice showed a decrease in the left ventricular outflow tract (LVOT) peak velocity, ejection fraction, and fractional shortening, showing that endogenous non-erythroid EPO response is protective for heart function. …”

Dissociative CO Photosubstitution in M(CO)₄(1,4-diazabutadiene) Complexes (M = W, Mo) by an Olefin Affording Novel <i>f</i><i>ac</i>-M(CO)₃(1,4-diazabutadiene... by Friedrich-Wilhelm Grevels (2671306)

“…Quantum yield measurements at 254, 302, 365, and 405 nm revealed a gradual decrease from Φ ≈ 0.1 to 0.02 and then a sharp drop to 0.001 at 548 nm (CTML excitation). …”

CDA deficiency leads to excess dCTP, inhibiting PARP-1 activity and leading to UFB formation. by Simon Gemble (168663)

“…(G) (1) CDA deficiency leads to intracellular dCTP accumulation, decreasing basal PARP-1 activity. (2) The decrease in basal PARP-1 activity leads to an increase in unreplicated DNA sequences (preferentially at centromeres and CFS sites). (3) During late G2/early mitosis, some of this unreplicated DNA is probably processed by MUS81-EME1 and ERCC1 nucleases as previously suggested [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1005384#pgen.1005384.ref036" target="_blank">36</a>, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1005384#pgen.1005384.ref012" target="_blank">12</a>], leading to DNA synthesis during metaphase (EdU foci) and preventing supernumerary UFB formation. (4) Some of the excess unreplicated DNA sequences are not processed by the nucleases, leading to supernumerary UFB formation.…”

The <i>casy-1</i> isoforms functions in GABAergic neurons to regulate synaptic transmission. by Shruti Thapliyal (4951993)

“…Cholinergic synapses are largely normal in <i>casy-1</i> mutants, while GABAergic synapses showed a subtle but significant decrease in fluorescent intensity when compared to WT animals. …”

Table1_Leishmania major surface components and DKK1 signalling via LRP6 promote migration and longevity of neutrophils in the infection site.docx by Olivia C. Ihedioha (19925886)

“…Relative to the WT controls, Δads1^- parasite-infected mice showed a sustained decrease in neutrophils and neutrophil-platelet aggregates (for at least 14 days PI), while neutrophils returned to normal in Δlpg1^- parasite-infected mice after day 3 PI.…”

Antitumor Activity and Induction of TP53-Dependent Apoptosis toward Ovarian Clear Cell Adenocarcinoma by the Dual PI3K/mTOR Inhibitor DS-7423 by Tomoko Kashiyama (162572)

“…In mouse xenograft models, DS-7423 suppressed the tumor growth of OCCA in a dose-dependent manner. Flow cytometry analysis revealed a decrease in S-phase cell populations in all the cell lines and an increase in sub-G1 cell populations following treatment with DS-7423 in six of the nine OCCA cell lines tested. …”

Table_1_Narrowing row spacing and adding inter-block promote the grain filling and flag leaf photosynthetic rate of wheat under enlarged drip tube spacing system.xlsx by Jianguo Jing (18767383)

“…The decline of NS22 (9.93%) was higher than that of NS44 (9.04%), and both cultivars also showed a greater decrease in grain weight and average grain-filling rate (AGFR) of inferior grains (NS22: 23.19%, 13.97%; NS44: 7.78%, 5.86%) than the superior grains (NS22: 10.60%, 8.33%; NS44: 4.89%, 4.62%). …”

Image2_Neuronal nitric oxide synthase required for erythropoietin modulation of heart function in mice.pdf by Jeeyoung Lee (2638744)

“…</p><p>Results: ΔEPORE mice showed a decrease in the left ventricular outflow tract (LVOT) peak velocity, ejection fraction, and fractional shortening, showing that endogenous non-erythroid EPO response is protective for heart function. …”

Image_3_Comparison of long-term cardiovascular and renal outcomes between percutaneous coronary intervention and coronary artery bypass grafting in multi-vessel disease with chroni... by Woochan Kwon (13772311)

“…However, PCI-CR had a comparable 5-year death, MI, or stroke rate to CABG (HR: 0.86, 95% CI 0.54–1.38, p = 0.54).…”

Modulating the Coordination Environment of Cu-Embedded Mo<i>X</i>₂ (<i>X</i> = S, Se, and Te) Monolayers for Electrocatalytic Reduction of CO₂ to CH<sub>4</su... by Thamarainathan Doulassiramane (17382128)

“…Among the C1 products, CH₄ is selectively produced in all three SACs. Notably, there is a decrease in the limiting potential (<i>U</i>_<i>L</i>) when <i>X</i> changes from S to Te in Cu-Mo<i>X</i>₂. …”

DataSheet2_Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer.xlsx by Emily M. J. Fennell (6654536)

“…GO analysis of these data demonstrated additional similarity of response to ONC201 and TR-57, including a decrease in transcripts related to the mitochondrial inner membrane and matrix, cell cycle, and nucleus, and increases in other nuclear transcripts and transcripts related to metal-ion binding. …”

Acetate-Bridged Platinum(III) Complexes Derived from Cisplatin by Justin J. Wilson (1980262)

“…Density functional theory calculations suggest that the decrease in the ¹⁴N line width arises from a diminished electric field gradient at the ¹⁴N nuclei in the higher valent compounds. …”

DataSheet_1_Narrowing row spacing and adding inter-block promote the grain filling and flag leaf photosynthetic rate of wheat under enlarged drip tube spacing system.zip by Jianguo Jing (18767383)

“…The decline of NS22 (9.93%) was higher than that of NS44 (9.04%), and both cultivars also showed a greater decrease in grain weight and average grain-filling rate (AGFR) of inferior grains (NS22: 23.19%, 13.97%; NS44: 7.78%, 5.86%) than the superior grains (NS22: 10.60%, 8.33%; NS44: 4.89%, 4.62%). …”

Image4_Neuronal nitric oxide synthase required for erythropoietin modulation of heart function in mice.pdf by Jeeyoung Lee (2638744)

“…</p><p>Results: ΔEPORE mice showed a decrease in the left ventricular outflow tract (LVOT) peak velocity, ejection fraction, and fractional shortening, showing that endogenous non-erythroid EPO response is protective for heart function. …”

Neutralization of point mutants of B.1.351 and D614G spike-pseudotyped lentiviral particles by convalescent plasmas from B.1.351 and early 2020-infected individuals. by Allison J. Greaney (11046384)

“…<b>(B)</b> The fold-decrease in neutralization for samples shown in <b><a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1010248#ppat.1010248.g005" target="_blank">Fig 5</a></b>, with the addition of previously measured neutralization by samples from 6 early 2020 convalescent individuals collected approximately 100 days post-symptom onset [<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1010248#ppat.1010248.ref038" target="_blank">38</a>]. …”

<i>Smad6</i> repression in senescence. by Atsushi Kaneda (198186)

“…The number of SA-β-gal(+) cells were significantly decreased in <i>Smad6</i>-introduced RasV12 cells compared with RasV12 (See also <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1002359#pgen.1002359.s008" target="_blank">Figure S8</a>). …”

Data Sheet 3_Cepharanthine may inhibit the proliferation of prostate cells by blocking the EGFR/PI3K/AKT signaling pathway: comprehensive network analysis, molecular docking, and e... by Yin Huang (179237)

“…Celigo counting revealed a significant decrease in both cell lines after 24–96 h of CEP treatment. …”