<i>In vitro</i> blocking effect of PD-1-PD-L1 interactions on the effector T cell functions and survival among PTB patients. by Amar Singh (134922)

“…Lymphocytes were gated based on their scatter (FSC/SSC) profile and further gated on CD3⁺ T cells. (<b>A</b>) Representative FACS plots shows production of IFN-γ by CD3⁺ T cells which markedly increases upon blocking PD-1-PD-L1 interaction (<b>B</b>) Each histogram depicts the effect of PD-1, PD-L1 blocking on the percentage of IFN-γ⁺ CD3⁺ T cells (mean ± S.E.M. for n = 8). …”

Table_1_Transcriptomic and Epigenomic Dynamics of Honey Bees in Response to Lethal Viral Infection.XLSX by Hongmei Li-Byarlay (5227208)

“…Israeli Acute Paralysis Virus (IAPV) is emerging as a model virus since its association with severe colony losses. …”

DataSheet_1_Associations between disrupted functional brain network topology and cognitive impairment in patients with rectal cancer during chemotherapy.docx by Yesong Guo (13108692)

“…The functional brain network had preserved small-world topological features but with a tendency towards higher path length in the whole network. …”

Image_2_An in vitro Model of Human Retinal Detachment Reveals Successive Death Pathway Activations.tif by Jelena Potic (9693587)

“…Almost no Cleaved-Caspase3 signal was observed, whereas a transient augmentation at day 3 of AIF-positive cells was observed to be about 10-fold in comparison to the control group (n = 2). …”

Image 2_N1-methylnicotinamide promotes age-related cochlear damage via the overexpression of SIRT1.tif by Toru Miwa (8528715)

“…<p>Age-related hearing loss (ARHL) is a complex condition with genetic, aging, and environmental influences. …”

DataSheet3_Guanxinkang Decoction Attenuates the Inflammation in Atherosclerosis by Regulating Efferocytosis and MAPKs Signaling Pathway in LDLR−/− Mice and RAW264.7 Cells.ZIP by Yifan Zhang (119570)

“…<p>Guanxinkang decoction (GXK), a traditional Chinese medicinal drug, is used to treat cardiovascular disease. …”

Image_1.TIF by Wei-Di He (4920472)

“…To investigate the early cold stress response of Dajiao, here we applied comparative membrane proteomics analysis for both cold-sensitive Cavendish and cold-tolerant Dajiao bananas subjected to cold stress at 10°C for 0, 3, and 6 h. A total of 2,333 and 1,834 proteins were identified in Cavendish and Dajiao, respectively. …”

Table_4_Additional prognostic value of polymorphisms within the 3′-untranslated region of programmed cell death pathway genes in early-stage breast cancer.docx by Hanxi Chen (11578225)

“…</p>Methods<p>In this study, we genotyped 28 potentially functional single nucleotide polymorphisms (SNPs) in 23 PCD pathway genes in 1,177 patients with early-stage breast cancer (EBC) from a Han Chinese population. The median follow-up period was 174 months.…”

Table_1_Exosome Component 4 Promotes Epithelial Ovarian Cancer Cell Proliferation, Migration, and Invasion via the Wnt Pathway.xlsx by Chang Xiong (11331110)

“…EXOSC4 is expected to be a novel biomarker and molecular target in EOC.</p>…”

Data_Sheet_1_Genome-Wide Analysis of the Soybean TIFY Family and Identification of GmTIFY10e and GmTIFY10g Response to Salt Stress.docx by Ya-Li Liu (530354)

“…Further analysis demonstrated that GmTIFY10e and GmTIFY10g genes changed the expression levels of genes related to the ABA signal pathway, including GmSnRK2, GmPP2C, GmMYC2, GmCAT1, and GmPOD. This study provides a basis for comprehensive analysis of the role of soybean TIFY genes in stress response in the future.…”

Table 1_Enterococcus faecalis strains derived from wild bird provide protection against Clostridium perfringens challenge in locally-sourced broilers.docx by Gerui Zhang (17630411)

“…Introduction<p>Necrotic enteritis (NE), caused by Clostridium perfringens, has seen a surge in chicken populations recently due to the ban on antibiotic growth promoters in feed.…”

Data_Sheet_2_Molecular Signatures of Neuroinflammation Induced by αSynuclein Aggregates in Microglial Cells.xlsx by Souvarish Sarkar (8382513)

“…We validated progranulin (PGRN) as a lysosomal PD-associated protein that is downregulated by αSyn_Agg in microglia in-vivo and is expressed by microglia in post-mortem PD brain, congruent with our in vitro findings.…”

Dendritic Cells from Crohn’s Disease Patients Show Aberrant STAT1 and STAT3 Signaling by Janne K. Nieminen (442997)

“…Studies on JAK/STAT signaling in DCs are, however, lacking in CD. We applied a flowcytometric single-cell-based phosphoepitope assay to evaluate STAT1 and STAT3 pathways in DC subsets from CD patients. …”

Data_Sheet_1_Liuwei Dihuang Decoction Alleviates Cognitive Dysfunction in Mice With D-Galactose-Induced Aging by Regulating Lipid Metabolism and Oxidative Stress via the Microbiota... by Baiyan Liu (12869393)

“…Liuwei Dihuang decoction (LW), a commonly applied Chinese medicine formula, is widely used for the treatment of aging-related diseases in China. …”

Video_3_Advanced Microscopy Reveals Complex Developmental and Subcellular Localization Patterns of ANNEXIN 1 in Arabidopsis.mp4 by Michaela Tichá (9207320)

“…Massive relocation and accumulation of ANN1-GFP at the PM and in Hechtian strands and reticulum in plasmolyzed cells suggest a possible osmoprotective role of ANN1-GFP during plasmolysis/deplasmolysis cycle. …”

DataSheet_1_microRNA-145-5p inhibits prostate cancer bone metastatic by modulating the epithelial-mesenchymal transition.csv by Bingfeng Luo (13718917)

“…Mimicry of miRNA-145-5p action raises the possibility of a novel target for treating Pca with bone metastases.…”

DataSheet_1_Additional prognostic value of polymorphisms within the 3′-untranslated region of programmed cell death pathway genes in early-stage breast cancer.pdf by Hanxi Chen (11578225)

“…</p>Methods<p>In this study, we genotyped 28 potentially functional single nucleotide polymorphisms (SNPs) in 23 PCD pathway genes in 1,177 patients with early-stage breast cancer (EBC) from a Han Chinese population. The median follow-up period was 174 months.…”

Image_1_Fengshi Gutong Capsule Attenuates Osteoarthritis by Inhibiting MAPK, NF-κB, AP-1, and Akt Pathways.tif by Yao-Xin Gao (5640092)

“…<p>Background and purpose: Fengshi Gutong capsule (FSGTC), a traditional herbal formula, has been used clinically in China for the treatment of arthritis. …”

Transgelin-2 is upregulated on activated B-cells and expressed in hyperplastic follicles in lupus erythematosus patients by Kaori Kiso (4437109)

“…We also suggest that TAGLN2 could be used as a marker for activated B-cells.</p></div>…”

Table_2_High-Throughput Analysis of Water-Soluble Forms of Choline and Related Metabolites in Human Milk by UPLC-MS/MS and Its Application.XLSX by Daniela Hampel (683851)

“…In order to enable the rapid assessment of choline intake for exclusively breastfed infants and to further investigate the associations between milk choline and maternal and infant status and other outcomes, we have developed a simplified method for the simultaneous analysis of human milk choline, glycerophosphocholine, phosphocholine, and the less abundant related metabolites betaine, carnitine, creatinine, dimethylglycine (DMG), methionine, and trimethylamine N-oxide (TMAO) using ultraperformance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS). …”