Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Syn... by Carlos Roca (4069366)

“…Recently, the phenothiazine FD44 has been identified as an inhibitor of this PPI, decreasing the abnormally high synapse number and enhancing associative learning in a FXS animal model. …”

Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Syn... by Carlos Roca (4069366)

“…Recently, the phenothiazine FD44 has been identified as an inhibitor of this PPI, decreasing the abnormally high synapse number and enhancing associative learning in a FXS animal model. …”

Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Syn... by Carlos Roca (4069366)

“…Recently, the phenothiazine FD44 has been identified as an inhibitor of this PPI, decreasing the abnormally high synapse number and enhancing associative learning in a FXS animal model. …”

Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Syn... by Carlos Roca (4069366)

“…Recently, the phenothiazine FD44 has been identified as an inhibitor of this PPI, decreasing the abnormally high synapse number and enhancing associative learning in a FXS animal model. …”

Increased hydrophilic plasma bile acids are correlated with protection from adiposity in skin-specific stearoyl-CoA desaturase-1 deficient mice by Sabrina N. Dumas (5474456)

“…<div><p>Stearoyl-CoA desaturase 1 (SCD1) catalyzes the rate limiting step in monounsaturated fatty acid synthesis by inserting a double bond at the delta-9 position of long-chain fatty acids. …”

Reprogramming pancreatic stellate cells via p53 activation: A putative target for pancreatic cancer therapy by Maya Saison-Ridinger (4666732)

“…<i>In vivo</i>, treatment of tumor-bearing mice with the clinical form of Nutlin-3a induces stromal p53 activation, reverses caPSCs activation, and decreases fibrosis. …”

BrdU staining of acinar cells, islet cells in duodenal area and ductule-like cells in foci area of sham rat and 90% PX rat. by Shigenori Ota (3389546)

“…<p>5 rats in each sham and 90% PX group were sacrificed in this experiment. (A) Representative immuno-staining images of acinar cells for BrdU in duodenal area of sham rat (upper panel), 90% PX rat at day3 (middle panel) and 90% PX rat at day 5 (lower panel). …”

Cyclosporine A eyedrops with self-nanoemulsifying drug delivery systems have improved physicochemical properties and efficacy against dry eye disease in a murine dry eye model by Seung Pil Bang (7878623)

“…Aqueous tear volume and fluorescein staining scores were improved in C-CsA- and SNEDDS-treated mice. Numbers of PAS-positive goblet cells and levels of inflammatory mediators were decreased by both C-CsA and SNEDDS, although SNEDDS resolved inflammation more effectively than C-CsA.…”

Effect of treatment with VA-lip siRNA HSP47 on BrdU uptake and HSP47 expression in islet of duodenal area. by Shigenori Ota (3389546)

“…<p>Quantification of BrdU uptake rate was carried out as described in the legend of <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0165747#pone.0165747.g003" target="_blank">Fig 3</a>. …”

miR-19 targets PTEN and mediates high mobility group protein B1(HMGB1)-induced proliferation and migration of human airway smooth muscle cells by Changchun Hou (2634661)

“…Functional studies indicated that overexpression of miR-19a enhanced the proliferation and migration of ASM cells, whereas inhibition of miR-19a decreased the proliferation and migration of ASM cells. …”

Table_1_Changes in Vitamin A Levels and the Effect of Early Vitamin A Supplementation on Vitamin A Levels in Infants Throughout the First 6 Months of Life: A Prospective Cohort Stu... by Huan Liu (281351)

“…From birth to 6 months, the percentage of infants with a VA level <0.70 μmol/L decreased from 88.6 to 19.5%. …”

Febrile urinary tract infection in a 38-month-old girl (patient no. by Han Byeol Lee (5519246)

“…(C) CEUS showed no hypoperfusion area in the left kidney in the early parenchymal phase but showed a suspicious decreased renal enhancement, and (D) showed multifocal lesions in the late parenchymal stage. …”

Febrile urinary tract infection in a 20-month-old boy (patient no. by Han Byeol Lee (5519246)

Transcriptional silencing is not a major cause for shortening of RLS in respiratory-deficient cells. by Dae-Gwan Yi (5410298)

Experiment A—likelihood of responding, stance, and response quality by treatment group and race. by Christopher L. Quarles (12501186)

Identification of OPG147 as a conserved inhibitor of the cGAS-mediated pathway. by Xue-Mei Yi (18851202)

Subjects:

Febrile urinary tract infection in a 2-month-old boy (patient no. by Han Byeol Lee (5519246)

“…<p><b>7).</b> (A) The grayscale ultrasound examination revealed no abnormalities in the right kidney. …”

Characterization of Dystrophin Deficient Rats: A New Model for Duchenne Muscular Dystrophy by Thibaut Larcher (331981)

“…<div><p>A few animal models of Duchenne muscular dystrophy (DMD) are available, large ones such as pigs or dogs being expensive and difficult to handle. …”

A Single Mutation in Chikungunya Virus Affects Vector Specificity and Epidemic Potential by Konstantin A Tsetsarkin (78536)

“…<div><p>Chikungunya virus (CHIKV) is an emerging arbovirus associated with several recent large-scale epidemics. The 2005–2006 epidemic on Reunion island that resulted in approximately 266,000 human cases was associated with a strain of CHIKV with a mutation in the envelope protein gene (E1-A226V). …”

Pineal Gland Calcification in Kurdistan: A Cross-Sectional Study of 480 Roentgenograms by Kahee A. Mohammed (3154056)

“…</p><p>Methods</p><p>This prospective study examined skull X-rays of 480 patients between the ages of 3 and 89 years who sought care at a large teaching public hospital in Duhok, Iraq from June 2014 to November 2014. …”