Discovery of Selective Dopamine Receptor Ligands Derived from (−)-Stepholidine via C‑3 Alkoxylation and C‑3/C‑9 Dialkoxylation by Hari K. Namballa (13363787)

Subjects:

Discovery of Selective Dopamine Receptor Ligands Derived from (−)-Stepholidine via C‑3 Alkoxylation and C‑3/C‑9 Dialkoxylation by Hari K. Namballa (13363787)

Subjects:

EMS decreases female fecundity and <i>Wolbachia</i> titre in the next generation in a dose-dependent manner. by Elves H. Duarte (10994504)

Diagnostic plots linear mixed model with MMSE. by Skadi Wilke (2818591)

“…</p><p>Conclusion</p><p>Treatment of the acute medical condition is associated with a fast decrease in delirium severity. Given the high incidence and prevalence of delirium in hospitalized older patients and its detrimental impact on cognition, abilities and personal independence further research needs to be done.…”

The decrease in blood flow disrupts CV pruning. by Lin Wen (557398)

Quantitative decrease of apolipoprotein-A1 by cohort. by Thierry Poynard (38084)

“…<p>Apolipoprotein-A1 decreased (P<0.001) in the three cohorts, starting early in January 2020 (red line with 95% confidence interval) in the US cohort (lower panel).…”

GI-1d-a: Comparison of estimates of people for dataset A (left bar) and B (right bar) per region. The largest discrepancies occur in areas of NE, SE and SW Germany and adjacent reg... by Isabell Schmidt (6331013)

AICc model selection analysis of linear regressions (models presented: ΔAICc <5) describing Pacific wren territory size, countersinging rate, and body condition response variables... by Kirsten A. Wilcox (11099051)

Melanin deposition on the dorsal abdominal wall decreases with aging. by Lindsay E. Martin (17377067)

Melanization potential decreases with higher temperature, aging, and infection. by Lindsay E. Martin (17377067)

Murine gastric pH decreases at peak infection. by Sarah E. Woodward (19429623)

Tracking error comparison of obstacle avoidance trajectories in scenarios with obstacles moving at a constant linear speed. by Long Di (9977453)

HFD induces LDs and decreases ER and mitochondria in nephrocytes. by Aleksandra Lubojemska (10746241)

“…(<b>E</b>) Low and high magnification views of pericardial nephrocytes (dotted outlines) from STD and HFD larvae, showing that HFD decreases mitochondria (marked with anti-ATP5A) and ER (marked with anti-KDEL) but increases LDs (marked with LipidTOX). …”

In superadditive networks, more enhancers decrease noise and fidelity. by Alvaro Fletcher (15675430)

“…<p>(A) Superadditivity is implemented in our model by linearly increasing <i>k</i>_on rates and linearly decreasing <i>k</i>_off rates. …”

Pendulum trajectories of Exp. 2 with decreased target radius (↓ <i>r</i>_<i>t</i>). by Annika Schmidt (2502097)

Prediction of linear and discontinuous epitopes in SmTPI and TsTPIs. by Pedro Jimenez-Sandoval (831603)

Pharmacological inhibition of EGFR decreases reduces a subset of the inflammatory response at day 2 post-infection. by Marc Swidergall (185453)

Ultrasound imaging shows decreased density in treatment tumors. by Anthony B. Eason (6294305)

Dynorphin Neuropeptides Decrease Apparent Proton Affinity of ASIC1a by Occluding the Acidic Pocket by Lilia Leisle (11356934)

“…We confirmed experimentally that the interaction is predominantly driven by electrostatic forces, and using noncanonical amino acids as photo-cross-linkers, we identified 16 residues in ASIC1a contributing to Big Dyn binding. Covalently tethering Big Dyn to its ASIC1a binding site dramatically decreased the proton sensitivity of channel activation, suggesting that Big Dyn stabilizes a resting conformation of ASIC1a and dissociates from its binding site during channel opening.…”

Dynorphin Neuropeptides Decrease Apparent Proton Affinity of ASIC1a by Occluding the Acidic Pocket by Lilia Leisle (11356934)

“…We confirmed experimentally that the interaction is predominantly driven by electrostatic forces, and using noncanonical amino acids as photo-cross-linkers, we identified 16 residues in ASIC1a contributing to Big Dyn binding. Covalently tethering Big Dyn to its ASIC1a binding site dramatically decreased the proton sensitivity of channel activation, suggesting that Big Dyn stabilizes a resting conformation of ASIC1a and dissociates from its binding site during channel opening.…”