Da-Yuan-Yin decoction suppresses NETs formation, inhibits the IL-23/JAK2/STAT3 signalling pathway, and modulates metabolic profiles and gut microbiota composition in damp-heat synd... by Yun Yang (417125)

“…<p>Da-Yuan-Yin Decoction (DYY), used since the early Qing Dynasty in China for damp-heat syndrome, was evaluated for its comprehensive protective effects.</p> <p>Rats received a high-fat/high-sugar diet for 14 days, then daily exposure to high temperature/humidity (31.0 ± 0.5°C, 85%-95%) for 10 hours over 14 days. …”

Table 1_Cell-free supernatant of Levilactobacillus brevis (RAMULAB51) from coconut inflorescence sap (Neera) enhances glucose uptake and PPAR-γ in 3T3-L1 adipocytes and inhibits α-... by Chandana Kumari V B (17543976)

“…It strongly co-aggregated with Micrococcus luteus and Bacillus subtilis, showing significant antimicrobial activity with a 24 mm inhibition zone against Micrococcus luteus. …”

Expression of COX-2, IL-1β, and TOLLIP after treatment with lipopolysaccharide or IL-1β as an inflammatory stimulus. by Yu Hui Won (3331458)

“…<p>(A) Validation of COX-2 by induced inflammation with LPS in fibroblasts from ALS patients (lane 1, untreated ALS patient-derived iPSCs; lane 2, 1 μg/mL LPS-treated ALS patient-derived iPSCs; lane 3, 5 μg/mL LPS-treated ALS patient-derived iPSCs; lane 4, untreated normal-derived iPSCs; lane 5, 1 μg/mL LPS-treated normal-derived iPSCs; lane 6, 5 μg/mL LPS-treated normal-derived iPSCs). …”

Class I histone deacetylase inhibitor MS-275 attenuates vasoconstriction and inflammation in angiotensin II-induced hypertension by Yuhee Ryu (3370769)

“…</p><p>Methods and results</p><p>MS-275 inhibited the activity of HDAC1, HDAC2, and HDAC3, while RGFP966 weakly inhibited that of HDAC3 in a cell-free system. MS-275 and RGFP966 treatment reduced systolic blood pressure and thickness of the aorta wall in Ang II-induced hypertensive mice. …”

FIGURE 1 from Inhibition of PRL2 Upregulates PTEN and Attenuates Tumor Growth in <i>Tp53</i>-deficient Sarcoma and Lymphoma Mouse Models by Frederick Nguele Meke (17718099)

“…<p>PRL2 expression inversely correlates with PTEN and survival in human patients with sarcoma. <b>A,</b> Scatter plot of PRL2 mRNA data showing the increased expression of PRL2 mRNA in patients with TCGA SARC with TP53 mutations. …”

Yeast essential gene screens for modulators of αSyn toxicity. by Blagovesta Popova (14546)

“…<p><b>(A)</b> Growth assays of yeast cells expressing <i>GAL1</i>-driven αSyn-GFP from two genomically integrated copies in Y7092 background, used as query strain in the <i>Tet</i>-Promoters Hughes collection (yTHC) and decreased abundance by mRNA perturbation (DAmP) collection screens, with empty vector as control. …”

Image_1_Roles of Cadherin2 in Thyroid Cancer.tif by Yun Chen (279569)

“…Background<p>The majority of drug-resistant cells in Thyroid cancer (THCA) tend to exhibit an Epithelial mesenchymal transition (EMT) phenotype, and abnormal expression of the cell adhesion molecule Cadherin2 (CDH2) is a hallmark of EMT. However, the roles of CDH2 in THCA and its underlying mechanisms are unknown.…”

Semi-knockout YAP rescue heart function from valve thickening. by Wei Yu (43094)

“…<p>(A) Gross front view of hearts from 9-month-old <i>Tie2</i>^<i>Cre+</i><i>;Vgll4</i>^<i>fl/-</i>; <i>Tie2</i>^<i>Cre+</i><i>;Vgll4</i>^<i>fl/-</i><i>;Yap</i>^<i>fl/+</i> and <i>Vgll4</i>^<i>fl/-</i><i>;Yap</i>^<i>fl/+</i> hearts. …”

Intraplantar acid injection produced TRPV1-mediated time-dependent behavioral hyperalgesia and spinal neuron sensitization. by He Liu (67509)

“…<p>(A) Intraplantar injection of pH 5.0 PBS (10-µl), not pH 7.4 PBS (10-µl), produced thermal (top) and mechanical (bottom) hyperalgesia. …”

Data Sheet 1_Improved myocardial mitochondrial energy metabolism in rats with chronic heart failure by modifying fatty acid oxidation using an extract of sand-fired aconite (Jianch... by Hongtao Zhang (167639)

“…This study investigated myocardial mitochondrial energy metabolism as a therapeutic mechanism of SFAS in doxorubicin-induced chronic heart failure (CHF) rats.…”

Image_3_Abnormal Shift in B Memory Cell Profile Is Associated With the Expansion of Circulating T Follicular Helper Cells via ICOS Signaling During Acute HIV-1 Infection.tif by Xiaofan Lu (2319541)

“…Twenty-five study subjects were enrolled from the Beijing PRIMO clinical cohort, a prospective cohort of HIV-1-negative men who have sex with men (MSM) for the identification of cases of acute HIV-1 infection (AHI) at Beijing Youan Hospital, Capital Medical University. …”

Binding and entry of TP4 peptides in <i>E</i>. <i>coli</i>. by Shih-Han Wang (430693)

“…<p>(A) TP4 and FITC-TP4 peptides exerted similar bactericidal ability against <i>E</i>. …”

Image_6_Phenotypic changes of γδ T cells in Plasmodium falciparum placental malaria and pregnancy outcomes in women at delivery in Cameroon.jpeg by Chris Marco Mbianda Nana (14492776)

“…This study sought to investigate the involvement of γδ T cells and its subsets in placental Plasmodium falciparum malaria.</p>Methods<p>In a case-control study conducted in Yaoundé, Cameroon from March 2022 to May 2023, peripheral, placental and cord blood samples were collected from 50 women at delivery (29 PM negative: PM- and 21 PM positive: PM+; as diagnosed by light microscopy). …”

Table5_Evidence and Potential Mechanism of Action of Lithospermum erythrorhizon and Its Active Components for Psoriasis.docx by Jiao Wang (47178)

“…Preclinical evidence has shown that the active components of Lithospermum erythrorhizon exhibit a potential anti-inflammatory effect, promote keratinocyte apoptosis, inhibit keratinocyte proliferation and angiogenesis, and block the cell cycle. …”

Radio-protective efficacy of <i>Gymnema sylvestre</i> on <i>Pangasius sutchi against</i> gamma (⁶⁰Co) irradiation by Pamela Sinha (11613846)

“…<p>Freshwater fish <i>Pangasius sutchi</i> was used in this study as a vertebrate model. We evaluated the induction of certain antioxidant enzymes in various vital organs. …”

Image_1_Gender- and Age-Associated Differences in Bone Marrow Adipose Tissue and Bone Marrow Fat Unsaturation Throughout the Skeleton, Quantified Using Chemical Shift Encoding-Base... by Kerensa M. Beekman (12467511)

“…<p>Bone marrow adipose tissue (BMAT) is a dynamic tissue which is associated with osteoporosis, bone metastasis, and primary bone tumors. …”

Image_14_Organelle Crosstalk Regulators Are Regulated in Diseases, Tumors, and Regulatory T Cells: Novel Classification of Organelle Crosstalk Regulators.tif by Ming Liu (105953)

“…<p>To examine whether the expressions of 260 organelle crosstalk regulators (OCRGs) in 16 functional groups are modulated in 23 diseases and 28 tumors, we performed extensive -omics data mining analyses and made a set of significant findings: (1) the ratios of upregulated vs. downregulated OCRGs are 1:2.8 in acute inflammations, 1:1 in metabolic diseases, 1:1.2 in autoimmune diseases, and 1:3.8 in organ failures; (2) sepsis and trauma-upregulated OCRG groups such as vesicle, mitochondrial (MT) fission, and mitophagy but not others, are termed as the cell crisis-handling OCRGs. …”

DataSheet_1_Antigenic Cross-Reactivity Between SARS-CoV-2 S1-RBD and Its Receptor ACE2.docx by Yen-Chung Lai (6480704)

“…In this study, we confirmed the increase in antibodies against ACE2 in patients with COVID-19 and found a positive correlation between the amounts of antibodies against ACE2 and S1-RBD. …”

DataSheet_1_Sex-specific differences in immunogenomic features of response to immune checkpoint blockade.pdf by Susan C. Scott (13191618)

DataSheet_1_Kynurenic Acid and Its Analogue SZR-72 Ameliorate the Severity of Experimental Acute Necrotizing Pancreatitis.pdf by Zsolt Balla (457272)