Single-cell analysis reveals non-linear relationship between H3K27me3 and BCL6. by Ofir Griess (14761465)

“…H3K27me3 and BCL6 show a non-linear relationship. <b>E.</b> Model for the non-linear ‘bell-shaped’ relationship between H3K27me3 and BCL6. …”

Effectiveness of Omega-3 Polyunsaturated Fatty Acids in Non-Alcoholic Fatty Liver Disease: A Meta-Analysis of Randomized Controlled Trials by Xi-Xi He (3202416)

“…</p><p>Conclusions</p><p>Supplementation with ω-3 PUFA is a practical and effective treatment for NAFLD to decrease ALT, TC and increase HDL-C, especially to decrease TG. …”

Carboxypeptidase O is a lipid droplet-associated enzyme able to cleave both acidic and polar C-terminal amino acids by Linnea C. Burke (5925410)

“…Membrane cholesterol levels played a role in the distribution and <i>in vitro</i> enzymatic activity of CPO, with cholesterol enrichment leading to decreased lipid droplet association and enzymatic activity. …”

Bacteria Induce Prolonged PMN Survival via a Phosphatidylcholine-Specific Phospholipase C- and Protein Kinase C-Dependent Mechanism by Saskia F. Erttmann (517791)

“…Infected cells exhibit decreased caspase 3 and 8 activities, increased mitochondrial integrity and are resistant to apoptosis induced by a death receptor ligand. …”

Abnormal Chondrocyte Apoptosis in the Cartilage Growth Plate is Influenced by Genetic Background and Deletion of CHOP in a Targeted Mouse Model of Pseudoachondroplasia by Katarzyna A. Piróg (490536)

“…Mouse models of PSACH show variable retention of mutant COMP in the ER of chondrocytes, however, in each case a different stress pathway is activated and the underlying disease mechanisms remain largely unknown. …”

(+)-Rutamarin as a Dual Inducer of Both GLUT4 Translocation and Expression Efficiently Ameliorates Glucose Homeostasis in Insulin-Resistant Mice by Yu Zhang (12946)

“…<div><p>Glucose transporter 4 (GLUT4) is a principal glucose transporter in response to insulin, and impaired translocation or decreased expression of GLUT4 is believed to be one of the major pathological features of type 2 diabetes mellitus (T2DM). …”

DataSheet_1_Deletion of a Genetic Region of lp17 Affects Plasmid Copy Number in Borrelia burgdorferi.docx by Jessica K. Wong (12403687)

“…This genome consists of over 20 plasmids, and the regulatory mechanisms of plasmid maintenance and replication are largely unknown. The bbd21 gene, encoded on lp17 and a member of the paralogous family 32 proteins, was originally proposed to be a putative parA orthologue involved with plasmid partitioning; however, this function has not been confirmed to date. …”

A Genetic Screen for Dihydropyridine (DHP)-Resistant Worms Reveals New Residues Required for DHP-Blockage of Mammalian Calcium Channels by Trevor C. Y. Kwok (46148)

“…As a Ca_v1 channel crystal structure is lacking, the current model of DHP action has largely been achieved by investigating the role of candidate Ca_v1 residues in mediating DHP-sensitivity. …”

Image_1_A Comparison of Forensic Age Prediction Models Using Data From Four DNA Methylation Technologies.TIF by A. Freire-Aradas (9255545)

“…DNA methylation has been established as the biomarker of choice for age prediction, since it was observed that specific CpG positions in the genome show systematic changes during an individual’s lifetime, with progressive increases or decreases in methylation levels. Subsequently, several forensic age prediction models have been reported, providing average age prediction error ranges of ±3–4 years, using a broad spectrum of technologies and underlying statistical analyses. …”

Table_2_A Comparison of Forensic Age Prediction Models Using Data From Four DNA Methylation Technologies.XLSX by A. Freire-Aradas (9255545)

“…DNA methylation has been established as the biomarker of choice for age prediction, since it was observed that specific CpG positions in the genome show systematic changes during an individual’s lifetime, with progressive increases or decreases in methylation levels. Subsequently, several forensic age prediction models have been reported, providing average age prediction error ranges of ±3–4 years, using a broad spectrum of technologies and underlying statistical analyses. …”

Table_1_A Comparison of Forensic Age Prediction Models Using Data From Four DNA Methylation Technologies.XLSX by A. Freire-Aradas (9255545)

“…DNA methylation has been established as the biomarker of choice for age prediction, since it was observed that specific CpG positions in the genome show systematic changes during an individual’s lifetime, with progressive increases or decreases in methylation levels. Subsequently, several forensic age prediction models have been reported, providing average age prediction error ranges of ±3–4 years, using a broad spectrum of technologies and underlying statistical analyses. …”

Table_3_A Comparison of Forensic Age Prediction Models Using Data From Four DNA Methylation Technologies.XLSX by A. Freire-Aradas (9255545)

“…DNA methylation has been established as the biomarker of choice for age prediction, since it was observed that specific CpG positions in the genome show systematic changes during an individual’s lifetime, with progressive increases or decreases in methylation levels. Subsequently, several forensic age prediction models have been reported, providing average age prediction error ranges of ±3–4 years, using a broad spectrum of technologies and underlying statistical analyses. …”

Proposed mechanism for preventative action of A2bAR on insulin signaling. by Hillary Johnston-Cox (148752)

“…Reduced cytokine expression prevents the inflammation-induced decrease in tissue IRS-2 by the direct action of inflammatory cytokines <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0098775#pone.0098775-BouraHalfon1" target="_blank">[11]</a>–<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0098775#pone.0098775-Hotamisligil1" target="_blank">[13]</a>. …”

Effect of NAD⁺ boosting by NR on <i>Klotho</i> and <i>Napi2c</i> in the kidney. by Marya Morevati (5593805)

“…<b>(F)</b> mRNA of <i>Napi2c</i> was significantly decreased 24 hours after IRI in both groups and administration with NR resulted in a further decrease. …”

PHF23 (plant homeodomain finger protein 23) negatively regulates cell autophagy by promoting ubiquitination and degradation of E3 ligase LRSAM1 by Zhenda Wang (412280)

“…<p>Autophagy is a multistep process that involves the degradation and digestion of intracellular components by the lysosome. …”

Novel DNA Aptamer for CYP24A1 Inhibition with Enhanced Antiproliferative Activity in Cancer Cells by Madhu Biyani (12427332)

“…Overexpression of the vitamin D3-inactivating enzyme CYP24A1 (cytochrome P450 family 24 subfamily and hereafter referred to as CYP24) can cause chronic kidney diseases, osteoporosis, and several types of cancers. …”

Novel DNA Aptamer for CYP24A1 Inhibition with Enhanced Antiproliferative Activity in Cancer Cells by Madhu Biyani (12427332)

“…Overexpression of the vitamin D3-inactivating enzyme CYP24A1 (cytochrome P450 family 24 subfamily and hereafter referred to as CYP24) can cause chronic kidney diseases, osteoporosis, and several types of cancers. …”

Novel DNA Aptamer for CYP24A1 Inhibition with Enhanced Antiproliferative Activity in Cancer Cells by Madhu Biyani (12427332)

“…Overexpression of the vitamin D3-inactivating enzyme CYP24A1 (cytochrome P450 family 24 subfamily and hereafter referred to as CYP24) can cause chronic kidney diseases, osteoporosis, and several types of cancers. …”

Novel DNA Aptamer for CYP24A1 Inhibition with Enhanced Antiproliferative Activity in Cancer Cells by Madhu Biyani (12427332)

“…Overexpression of the vitamin D3-inactivating enzyme CYP24A1 (cytochrome P450 family 24 subfamily and hereafter referred to as CYP24) can cause chronic kidney diseases, osteoporosis, and several types of cancers. …”

Novel DNA Aptamer for CYP24A1 Inhibition with Enhanced Antiproliferative Activity in Cancer Cells by Madhu Biyani (12427332)

“…Overexpression of the vitamin D3-inactivating enzyme CYP24A1 (cytochrome P450 family 24 subfamily and hereafter referred to as CYP24) can cause chronic kidney diseases, osteoporosis, and several types of cancers. …”