The Spastic Paraplegia-Associated Phospholipase DDHD1 Is a Primary Brain Phosphatidylinositol Lipase by Jordon M. Inloes (4717320)

“…Here we use a combination of untargeted and targeted metabolomics to compare the lipid content of brain tissue from DDHD1^+/+ and DDHD1^–/– mice, revealing that DDHD1 inactivation causes a substantial decrease in the level of polyunsaturated lysophosphatidylinositol (LPI) lipids and a corresponding increase in the level of phosphatidylinositol (PI) lipids. …”

Feedback Inhibition in the PhoQ/PhoP Signaling System by a Membrane Peptide by Andrew M. Lippa (255368)

“…Interestingly, we found that elimination of MgrB-mediated feedback did not have a significant effect on the kinetics of reporter protein production and did not decrease the variability in expression among cells. …”

Dissipative Self-Assembly of Patchy Particles under Nonequilibrium Drive: A Computational Study by Shubhadeep Nag (18888287)

“…Utilizing extensive Monte Carlo (MC) and Molecular Dynamics (MD) simulations, we provide insight into the effects of external forces that mirror natural and chemical processes on the assembly rates and the stability of the resulting assemblies comprising 8, 10, and 13 patchy particles. Implemented by a favorable bond-promoting drive in MC or a pulsed square wave potential in MD, our simulations reveal the role these external drives play in accelerating assembly kinetics and enhancing structural stability, evidenced by a decrease in the time to first assembly and an increase in the duration the system remains in an assembled state. …”

PARP-1 Modulation of mTOR Signaling in Response to a DNA Alkylating Agent by Chantal Éthier (36413)

“…In HEK293 cells exposed to the alkylating agent N-methyl-N’-nitro-N’-nitrosoguanine (MNNG), we show that PARP-1 activation triggers a necrotic cell death response. The massive poly(ADP-ribose) (PAR) synthesis following PARP-1 activation leads to the modulation of mTORC1 pathway. …”

CT sections and P–V curves in a patient with diffuse loss of lung aeration by Qin Lu (995)

“…</p><p></p> Image 1 shows a computed tomographic (CT) section representative of the whole lung obtained at zeron end-exoiratory pressure (ZEEP). …”

A Genetic and Pharmacological Analysis of Isoprenoid Pathway by LC-MS/MS in Fission Yeast by Tomonori Takami (124563)

“…Notably, in wild-type cells miconazole and terbinafine only slightly decreased ergosterol level. Altogether, these studies suggest that the pleiotropic phenotypes caused by the <em>hmg1-1</em> mutation and pravastatin might be due to decreased levels of isoprenoid pyrophosphates or other isoprenoid pathway intermediate products rather than due to a decreased ergosterol level.…”

Understanding the factors that influence stroke survivors to begin or resume exercise: a qualitative exploration by Helena Drummond (17871887)

“…Stroke survivors have previously expressed a lack of adequate knowledge and skills to engage in exercise.…”

Factors associated with postoperative signs and symptoms in teeth with periapical lesion: a longitudinal study by Erlange Andrade Borges Silva (14224193)

“…Female gender (beta = 1.02; p < 0.01), mandibular teeth (beta = 25.50; p < 0.01), medium root canal amplitude (beta = 0.93; p = 0.03), and edema (beta = 1.88; p < 0.01) were associated with increased postoperative pain and tenderness, while the use of analgesics (beta = -1.82; p < 0.01) and time in days (beta = -0.23; p < 0.01) were associated with a decrease in these signs and symptoms. Edema was considered a risk factor for analgesic requirement (Odds Ratio [OR] = 61.46; p < 0.01). …”

EFFECTS OF A PSYCHOLOGICAL SKILL TRAINING PROGRAM ON ANXIETY LEVELS IN TOP KARATE ATHLETES by Ana Vesković (7476821)

“…Further analysis indicated a decrease in cognitive anxiety and an increase in self-confidence among participants from the EXP group. …”

Dissipative Self-Assembly of Patchy Particles under Nonequilibrium Drive: A Computational Study by Shubhadeep Nag (18888287)

“…Utilizing extensive Monte Carlo (MC) and Molecular Dynamics (MD) simulations, we provide insight into the effects of external forces that mirror natural and chemical processes on the assembly rates and the stability of the resulting assemblies comprising 8, 10, and 13 patchy particles. Implemented by a favorable bond-promoting drive in MC or a pulsed square wave potential in MD, our simulations reveal the role these external drives play in accelerating assembly kinetics and enhancing structural stability, evidenced by a decrease in the time to first assembly and an increase in the duration the system remains in an assembled state. …”

Dissipative Self-Assembly of Patchy Particles under Nonequilibrium Drive: A Computational Study by Shubhadeep Nag (18888287)

“…Utilizing extensive Monte Carlo (MC) and Molecular Dynamics (MD) simulations, we provide insight into the effects of external forces that mirror natural and chemical processes on the assembly rates and the stability of the resulting assemblies comprising 8, 10, and 13 patchy particles. Implemented by a favorable bond-promoting drive in MC or a pulsed square wave potential in MD, our simulations reveal the role these external drives play in accelerating assembly kinetics and enhancing structural stability, evidenced by a decrease in the time to first assembly and an increase in the duration the system remains in an assembled state. …”

Conservation of frequency distribution among a population of spontaneously protruding Cos7 cells. by Xiao Ma (411875)

“…<p>(a) Snapshots of active and quiescent Cos7 cell protrusion for 30 min with an increment of 6 min, scale bar = 20μm (see also Video 1 and 3). …”

Effect of atenolol pre-treatment in heart damage in a model of intestinal ischemia-reperfusion by Mieko Okada (4696906)

“…<div><p>Abstract Purpose: To investigate the effects of atenolol in inflammatory mediator and oxidative stress in a myocardial injury by intestinal ischemia/reperfusion in rat model. …”

Tracing Nitrogen Flows Associated with Beef Supply Chains: A Consumption-Based Assessment by Anaís Ostroski (14009564)

“…Animal feed production is heavily dependent on synthetic fertilizers, and the consumption of beef products, in particular, is associated with high nitrogen footprints. Although there is a rich body of work on nutrient footprints of beef production, there is a gap in understanding the spatial distribution of the nutrient releases throughout the beef supply chain in the U.S. …”

Image_3_Chitotriosidase Activity Is Counterproductive in a Mouse Model of Systemic Candidiasis.jpg by Nicholas A. Schmitz (10307267)

“…<p>Mammalian cells do not produce chitin, an insoluble polymer of N-acetyl-D-glucosamine (GlcNAc), although chitin is a structural component of the cell wall of pathogenic microorganisms such as Candida albicans. …”

Single Molecule Nanospectroscopy Visualizes Proton-Transfer Processes within a Zeolite Crystal by Zoran Ristanović (1359162)

“…Interestingly, replacing <i>n</i>-heptane with 1-butanol as a solvent led to a reactivity decrease of several orders and shorter survival times of fluorescent products due to the strong chemisorption of 1-butanol onto the Brønsted acid sites. …”

Efficacy and Safety of Adalimumab in Patients with Behçet Uveitis: A Systematic Review and Meta-Analysis by Hidayet Sener (14372733)

“…In addition, ADA therapy resulted in decreased grade of intraocular inflammation [std diff, −1.187 (95%CI: -1.508, -0.866)] and macular thickness [std diff, −0.564 (95%CI: -0.843, -0.286)] and caused a decrease in CS dosage [std diff, −1.809 (95%CI: -2.420, -1.198)]. …”

Data_Sheet_1_Failure to Find a Conditioned Placebo Analgesic Response.docx by Magne A. Flaten (5570171)

“…<p>Background: Associative learning has, in several studies, been modulated by the sex of the participant. Consistent with this, a recent review found that conditioned nocebo effects are stronger in females than in males.…”

Spotlight on Mitochondrial Health: A Trailblazing Fluorescent Tool for Cancer Detection and Surgical Guidance by Wei Zhang (405)

“…The mitochondrial autophagy process of disease-related cells is usually accompanied by a decrease in polarity and pH, and the fluorescence sensing effects caused by these two factors are usually contradictory. …”

Safety of vaginal delivery in very low birthweight vertex singletons: a meta-analysis by Eran Barzilay (531642)

“…Vaginal delivery was associated with a significant decrease in mortality for the 1250–1500 g birthweight category (OR 0.57, 95% CI 0.36–0.92), while an increase in mortality in the 500–750 g category was not significant (OR 1.5, 95% CI 0.86–2.61). …”