Optimizing Arsenic Therapy by Selectively Targeting Leukemia Cells by Judith A. Carrall (16851639)

“…The end goal is to achieve dose reduction and decreased side effects of the resultant arsenic therapeutic agent. …”

Clinical significance of <i>STM</i>_<i>FCS</i>. by Peter A. Pahapill (8468607)

Increased endothelial cell-cell junction size on stiff matrices is diminished after simvastatin treatment. by Marsha C. Lampi (845609)

“…<p>Endothelial monolayers are stained for VE-cadherin and cell-cell junction sizes are measured with control and 1 μM simvastatin treatments. (A) Representative images of fluorescently stained VE-cadherin monolayers indicating where junction width measurements were made (black line). …”

Simvastatin reduces vinculin localization at cell-cell adhesions in endothelial monolayers. by Marsha C. Lampi (845609)

“…(C) Vinculin localization per monolayer at cell-cell adhesions, a readout of intercellular junction tension, is quantified and increases with matrix stiffness but is significantly decreased with the statin treatment at higher matrix stiffnesses (n = 3, 70–90 fields of view per condition). …”

Biofilm formation assays. by Zezhang T. Wen (135862)

“…The results demonstrate that PBP1a-deficiency significantly decreased biofilm formation by the deficient mutant (* indicates differences at <i>P</i><0.001 when compared to the wild-type, UA159 under the same conditions). …”

Canonical and Noncanonical Sites Determine NPT2A Binding Selectivity to NHERF1 PDZ1 by Tatyana Mamonova (753968)

“…Experimentally introduced mutation in PDZ1 (Glu43Asp and His27Asn) decreased binding to NPT2A. Conversely, introduction of Asp183Glu and Asn167His mutations in PDZ2 promoted the formation of favorable interactions yielding micromolar <i>K</i>_Ds. …”

Tomato HsfA1a plays a critical role in plant drought tolerance by activating <i>ATG</i> genes and inducing autophagy by Yu Wang (12152)

“…On the other hand, <i>HsfA1a</i>-silenced plants increased while its overexpression decreased the levels of insoluble proteins which were highly ubiquitinated under drought stress. …”

Figure S1 - Effects of Negative Pressure Wound Therapy on Mesenchymal Stem Cells Proliferation and Osteogenic Differentiation in a Fibrin Matrix by Jin Zhu (164147)

Functional connectivity and structural analysis of trial spinal cord stimulation responders in failed back surgery syndrome by Peter A. Pahapill (8468607)

“…There was a negative linear relationship (R² = 0.76, p<0.0022) between STM_FCS index and pain scores. …”

Proteolysis of CtrA is essential in <i>S</i>. <i>meliloti</i> and requires at least CpdR, RcdA and the last three amino acids of CtrA. by Francesco Pini (739798)

“…Pulse-chase experiment of showing decrease over time of radiolabeled CtrA in <i>S</i>. …”

Epigenome modulated xenobiotic detoxification pathways control DMBA-induced breast cancer in agouti A^vy/a mice by Simbarashe Mazambani (6683576)

“…Compared to pseudoagouti littermates, a significant decrease in tumour latency with increased tumour burden was observed in slightly mottled and yellow littermates (<i>p</i> ≤ 0.05). …”

Data_Sheet_1_Alanine Scanning Mutagenesis of the C-Terminal Cytosolic End of Gpm6a Identifies Key Residues Essential for the Formation of Filopodia.pdf by Nicolás M. Rosas (5712830)

“…Expression levels of both truncation mutants were not affected but we observed decrease in the amount of both truncated proteins on cell surface suggesting that the incapacity of the Gpm6a lacking C-terminus to induce filopodium formation is not due to the lower amount of Gpm6a on cell surface. …”

Ectopic expression of miR-181a enhances lymphoid differentiation in the <i>ETV6/RUNX1</i>-positive cell line and primary ALL blasts. by Yung-Li Yang (514952)

“…In the comparison with the infection control (NC), 181A1-LV-transduced cells derived from patient #1 and #2 both showed a decrease in CD10^High cells (Patient #1: NC 10.1% / MFI 40.92, 181A1 6.95% / MFI 39.51; Patient #2: NC 40.1% / MFI 424.28, 181A1 29.5% / MFI 444.24) and a relative increase in CD10^Low cells (Patient #1: NC 87.98% / MFI 165.49, 181A1 91.05% / MFI 156.68; Patient #2: NC 58.1% / MFI 1929.88, 181A1 69% / 1854.4). …”

Effect of BM pretreatment on CYP3A at mRNA and functional activity level. by Rajbir Singh (451210)

“…BM treatment decreases the mRNA levels of CYP3A1and CYP3A2 in liver and intestine as assessed by real-time PCR as described in Materials and Methods. …”

Cyclosporine Inhibits a Direct Interaction between Cyclophilins and Hepatitis C NS5A by Fiona Fernandes (251389)

“…Mutations in NS5A alone conferred decreased CsA susceptibility regardless of NS5B mutations.…”

Protein expression of FOXO3a in gastric cancer as evaluated by western blotting. by Xiao-bo Yang (4057414)

“…(<b>B</b>) Relative FOXO3a protein expression levels was remarkably decreased in 18 of 24 (75%) gastric tumor tissues compared with the corresponding adjacent non-tumorous tissues, (FOXO3a/GAPDH, n = 24, p = 0.019).…”

Effect of MNC hUCB cell administration on hematological response in the peripheral blood from G93A mice. by Svitlana Garbuzova-Davis (81764)

“…The lymphocyte percentage was significantly decreased in Media (p<0.001) and CsA (p<0.001) groups vs. hTgn. …”

Tumor vessel activity is inhibited by 6a-P peptide. by Tong-Young Lee (250877)

“…Immunohistochemistry result shows that VEGF/KDR complexes are colocalized with vessels (VWF staining) on PBS treated tumor (A; up panel). However, the staining signal is decreased after peptide treatment (A; lower panel). …”

Silica increased the Egr-1 DNA binding activity in A549 cells. by Ling Chu (434707)

“…<p>The binding activity of Egr-1 in A549 cells after exposure to silica was determined by EMSA experiments, and the binding activity of Egr-1 peaked after 60-minute exposure. …”

Changes to the distance between the human cytomegaloviral uORF2 start codon and the elongating ribosome stall do not change repressiveness or buffering, consistent with the collisi... by Ty A. Bottorff (14035065)