PD-1 and CTLA-4 up regulation on donor T cells is insufficient to prevent GvHD in allo-HSCT recipients by Mohammad S. Hossain (415643)

“…Similar differential patterns of donor T cell immune response were observed in a minor histocompatibility (miHA) mismatched transplant model of GvHD. …”

Data_Sheet_2_Investigation on the Pathological Mechanism of Frequent Exacerbators With Chronic Obstructive Pulmonary Disease Based on the Characteristics of Respiratory Flora.ZIP by Li Ke (688445)

“…<p>Chronic obstructive pulmonary disease (COPD) is a common obstructive respiratory disease characterized by persistent respiratory symptoms and limited airflow due to airway obstruction. …”

Data_Sheet_2_Dual Careers of Athletes During COVID-19 Lockdown.docx by Pascal Izzicupo (4336225)

“…<p>This study aimed to investigate the student-athletes' capability to face the academic, sport, and social challenges during the coronavirus disease 2019 (COVID-19) lockdown and to disclose novel aspects of dual careers. A 32-item online survey encompassing demographic characteristics, sport and university engagement, support and dual-career benefits, physical activity, sitting time, and the time deemed necessary to recover the previous level of performance was developed. …”

Table_2_Global, regional, and national years lived with disability due to blindness and vision loss from 1990 to 2019: Findings from the Global Burden of Disease Study 2019.docx by Shasha Li (139491)

“…Purpose<p>This study aimed to provide a comprehensive assessment of burden estimates and the secular trend of blindness and vision loss, as measured by years lived with disability (YLDs), at the global, regional, and national levels.…”

Image_5_The Influence of Training Load on Hematological Athlete Biological Passport Variables in Elite Cyclists.TIFF by Tiffany Astolfi (10322177)

“…Hbmass was 1030 ± 87 g (range: 842–1116 g) with no significant variations over time (P = 0.118), whereas PV was 4309 ± 350 mL (range: 3,688–4,751 mL) with a time-effect observed over the study time (P = 0.014). …”

Viral levels in the three compartments and activated monocytes with and w/o treatment. by R. Gilberto González (334654)

“…<p>A. Treated animals revealed lower plasma vRNA levels (~1 log) at endpoints when compared to untreated animals at 8 wpi (cART P = 0.019; MN_persistent P = 0.0063). …”

Data_Sheet_1_Selenium-enriched Cardamine violifolia improves growth performance with potential regulation of intestinal health and antioxidant function in weaned pigs.ZIP by Dan Wang (34472)

“…<p>This study was conducted to evaluate the effects of different Selenium (Se) sources on growth performance, intestinal function and antioxidant status of weaned piglets. A total of 300 weaned pigs were randomly allocated to 5 treatment groups with 5 replicates of 12 pigs/pen. …”

Deletion of p38α ameliorates tubular but not glomerular damage during anti-GBM nephritis. by Ralf Müller (118397)

“…<p>(A) Semi-quantitative scoring of tubular damage. p38α deletion significantly diminishes tubular damage (mean score 0.6±0.1, p<0.05 vs. control; n = 7) as compared to wild type mice (mean score 0.9±0.01; n = 7). …”

DataSheet_2_Hypothalamic-pituitary-adrenal axis activity and its relationship to the autonomic nervous system in patients with psychogenic erectile dysfunction.xlsx by Jinzhou Xu (10796826)

“…Higher parasympathetic activity combined with a higher cortisol awakening response was associated with greater perceived stress.…”

Effects of different doses of ticagrelor on platelet aggregation and endothelial function in diabetic patients with stable coronary artery disease by Meijiao He (666387)

“…The half standard-dose ticagrelor had a similar inhibitory effect on platelet inhibition as standard-dose ticagrelor, which was stronger than that of clopidogrel. …”

The assessment of grip strength in preschool-aged children with and without unilateral cerebral palsy by Griet Dequeker (18059414)

“…</p> <p>We assessed grip strength in 20 pre-school-aged children with predominantly spastic uCP (mean age 4y0 ± 1y2m) and 20 age-matched children without uCP (mean age 3y11m ± 1y3m) using the Martin Vigorimeter and MyoGrip to investigate test-retest reliability (intraclass correlation coefficients; ICC), known-group validity (comparative statistics) and convergent validity (correlation analyses) in a cross-sectional design.</p> <p>In both groups, test-retest reliability was excellent for both devices and both hands (ICC 0.91–0.97). …”

Image_1_Salivary Gland Extract Modulates the Infection of Two Leishmania enriettii Strains by Interfering With Macrophage Differentiation in the Model of Cavia porcellus.jpeg by Lucélia J. Pinheiro (4047901)

“…Animals experimentally inoculated developed a protuberance and/or lesion after the 4th and 5th weeks of infection. …”

Detection of apoptosis after cytoskeletal disruption in wild type and MEKK1-deficient cell lines. by Erin Tricker (355544)

“…<p><i>A</i>. DNA laddering is significantly decreased in the <i>MEKK1^−/−</i> DT40 and murine pre-B cell lines upon treatment with vinblastine, cytochalasin D, and okadaic acid, whereas the response to etoposide is unchanged. …”

Image_3_Deletion of Non-histidine Domains of Histidine Kinase CHK1 Diminishes the Infectivity of Candida albicans in an Oral Mucosal Model.TIF by Yahui Feng (3897082)

“…</p>Methods<p>The domain mutants CHK25 (^ΔS_TkcCHK1/Δchk1) and CHK26 (^ΔS_TkcΔgafCHK1/Δchk1) were first constructed by the his1-URA3-his1 method and confirmed by sequencing and Southern blots. A mouse tongue infection model was used to evaluate the hyphal invasion and fungal loads in each domain mutant, full-gene deletion mutant CHK21 (chk1Δ/chk1Δ), re-constituted strain CHK23 (chk1Δ/CHK1), and wild type (WT) from day 1 to day 5. …”

Image_1_Macrophages-Related Genes Biomarkers in the Deterioration of Atherosclerosis.TIFF by Yue Zheng (601811)

“…The hub DEMRGs and their interactions were analyzed using NetworkAnalyst 3.0 and for validation, the expressions of hub DEMRGs were analyzed using the GSE135055 and GSE116250 datasets as well as atherosclerosis and MI mice model.</p>Results<p>A total of 509 differentially expressed genes (DEGs) were correlated with the abundance of macrophages and were identified as DEMRGs (Pearson correlation coefficients (PCC) > 0.6), which were mainly enriched in extracellular structure organization, lysosomal membrane, MHC protein complex binding, and so on. …”

DataSheet3_Salvia chinensia Benth induces autophagy in esophageal cancer cells via AMPK/ULK1 signaling pathway.ZIP by Lei Jia (303610)

“…<p>Salvia chinensia Benth (Shijianchuan in Chinese, SJC) has been used as a traditional anti-cancer herb. SJC showed good anti-esophageal cancer efficacy based on our clinical application. …”

Image 5_N1-methylnicotinamide promotes age-related cochlear damage via the overexpression of SIRT1.tif by Toru Miwa (8528715)

“…<p>Age-related hearing loss (ARHL) is a complex condition with genetic, aging, and environmental influences. …”

Action of disinfectant solutions on adaptive capacity and virulence factors of the Candida spp. biofilms formed on acrylic resin by Mauricio Malheiros BADARÓ (12658626)

“…The NaOCl 0.25% is the most effective and could be suitable for use as a positive control.</p></div>…”

Full dataset. by Josephine Bourner (11462776)

“…When categorising lesions according to their type, if a single lesion type was present in the image, inter-rater reliability was moderate (κ = 0.671, z = 40.6) and agreement was good (P_o = 78%), but when multiple lesion types were shown in an image, both inter-rater reliability (κ = 0.153, z = 10.5) and agreement (P_o = 29%) decreased substantially.…”

Markers for each cluster. by Xiaoke Xu (3468623)

“…This infection can lead to neurological effects and establish a viral reservoir. Given the gaps in our understanding of how these cells respond <i>in vivo</i> to acute CNS infection, we conducted single-cell RNA sequencing (scRNA-seq) on myeloid cells from the brains of three rhesus macaques 12 days after SIV infection, along with three uninfected controls. …”