KRASness and PIK3CAness in Patients with Advanced Colorectal Cancer: Outcome after Treatment with Early-Phase Trials with Targeted Pathway Inhibitors by Ignacio Garrido-Laguna (160665)

“…Patients with <em>PIK3CA</em> mutations had a trend toward shorter progression-free survival when treated with anti-EGFR therapies (p = 0.07). …”

pone.0337200.t001 - by Razia Rashid Rahil (22772495)

“…Prior CER- stimulation led to a marked upregulation of osteogenic markers such as RUNX2, OPN, BMP2 and decreased contractile markers SM22-α and α- SMA in P_i-treated VSMCs as compared to control cells. …”

Image1_Combination of the Herbs Radix Rehmanniae and Cornus Officinalis Mitigated Testicular Damage From Diabetes Mellitus by Enhancing Glycolysis via the AGEs/RAGE/HIF-1α Axis.jpe... by Yuping Chen (484476)

“…Aminoguanidine (Ami) and FPS-ZM1, the AGEs and RAGE inhibitors, were used as a tool drug to study the mechanism, showing different degrees of protection against DM-induced reproductive damage. …”

Table_2_Comparative analyses of functional traits based on metabolome and economic traits variation of Bletilla striata: Contribution of intercropping.xlsx by Pengfei Deng (14806162)

“…<p>The intercropping practice has been regarded as a practical land-use selection to improve the management benefits of Bletilla striata plantations. …”

Table1_Effects of Maren Pills on the Intestinal Microflora and Short-Chain Fatty Acid Profile in Drug-Induced Slow Transit Constipation Model Rats.docx by Yu Zhan (462171)

“…<p>Background: Slow transit constipation (STC) is becoming a common and frequently occurring disease in today’s society, and it is necessary to explore the safe and effective treatment of STC.…”

Assessing the disparity: comparative toxicity of Copper in zebrafish larvae exposes alarming consequences of permissible concentrations in Brazil by Maria Vitória Takemura Mariano (17613858)

“…<p>Copper (Cu) is a naturally occurring metal with essential micronutrient properties. …”

Table7_α-Mangostin Alleviated HIF-1α-Mediated Angiogenesis in Rats With Adjuvant-Induced Arthritis by Suppressing Aerobic Glycolysis.XLSX by Tian-Tian Jiang (11857058)

“…<p>A previously validated anti-rheumatic compound α-mangostin (MAN) shows significant metabolism regulatory effects. …”

Comparative transcriptome analysis provides global insight into gene expression differences between two orchid cultivars by Yu Jiang (234328)

“…Biochemical analysis uncovered the contents of chlorophyll a, chlorophyll b, total chlorophyll and carotenoid were notably decreased in YL. …”

Data_Sheet_1_Molecular Signatures of Neuroinflammation Induced by αSynuclein Aggregates in Microglial Cells.xlsx by Souvarish Sarkar (8382513)

“…We validated progranulin (PGRN) as a lysosomal PD-associated protein that is downregulated by αSyn_Agg in microglia in-vivo and is expressed by microglia in post-mortem PD brain, congruent with our in vitro findings.…”

Image_2_Suppression of weed and insect populations by living cover crop mulches in organic squash production.jpg by Dylan Bruce (13913982)

“…Living mulches of Dutch white clover (Trifolium repens), annual ryegrass (Lolium multiflorum), and a mix of Dutch white clover and annual ryegrass were compared with full tillage cultivated ground and straw mulch controls for effect on yield, fruit marketability, weed and pest counts, and weed management time. …”

Immunization with an ApoB-100 Related Peptide Vaccine Attenuates Angiotensin-II Induced Hypertension and Renal Fibrosis in Mice by Tomoyuki Honjo (539273)

“…CD8+ T cells from p210 immunized mice displayed a different phenotype compared to CD8+ T cells from unimmunized controls. …”

Data Sheet 1_RvD2 mitigates TNFɑ-Induced mitochondrial reactive oxygen species through NRF2 signaling in placental trophoblasts.pdf by Taija Hahka (20983223)

“…</p>Discussion<p>These findings demonstrate that RvD2 functions as a positive regulator of endogenous antioxidant properties by enhancing NRF2 levels and mitigating mitochondrial ROS in placental trophoblasts.…”

Table_1.DOCX by Wei-Di He (4920472)

“…To investigate the early cold stress response of Dajiao, here we applied comparative membrane proteomics analysis for both cold-sensitive Cavendish and cold-tolerant Dajiao bananas subjected to cold stress at 10°C for 0, 3, and 6 h. A total of 2,333 and 1,834 proteins were identified in Cavendish and Dajiao, respectively. …”

Effect of recombinant human keratinocyte growth factor in inducing Ras–Raf–Erk pathway-mediated cell proliferation in emphysematous mice lung by Jai Prakash Muyal (7494032)

“…Hence, rHuKGF may prove to be a potential drug in the treatment of emphysema.…”

Myeloid cell comparison. by Xiaoke Xu (3468623)

“…This infection can lead to neurological effects and establish a viral reservoir. Given the gaps in our understanding of how these cells respond <i>in vivo</i> to acute CNS infection, we conducted single-cell RNA sequencing (scRNA-seq) on myeloid cells from the brains of three rhesus macaques 12 days after SIV infection, along with three uninfected controls. …”

Table_1_High-Throughput Analysis of Water-Soluble Forms of Choline and Related Metabolites in Human Milk by UPLC-MS/MS and Its Application.DOCX by Daniela Hampel (683851)

“…In order to enable the rapid assessment of choline intake for exclusively breastfed infants and to further investigate the associations between milk choline and maternal and infant status and other outcomes, we have developed a simplified method for the simultaneous analysis of human milk choline, glycerophosphocholine, phosphocholine, and the less abundant related metabolites betaine, carnitine, creatinine, dimethylglycine (DMG), methionine, and trimethylamine N-oxide (TMAO) using ultraperformance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS). …”

Data Sheet 1_Relay intercropped soybean promotes nodules development and nitrogen fixation by root exudates deposition.docx by Ping Lin (146330)

“…This study was conducted to investigate the relationship between crop root exudates and soybean nodule development under intercropping patterns.</p>Method<p>A two years field experiments was carried out and combined with pot experiments to quantify the effects of planting mode, i.e., relay intercropping and monocropping, and genotypes, i.e., supernodulating NTS1007(NTS), Nandou-12(ND) and Guixia-3(GX) on root exudates, rhizobium community structure, nodule development and nitrogen fixation ability.…”

Enhanced immunity against SARS-CoV-2 in returning Chinese individuals by Runyu Yuan (11843324)

“…Blood and throat swab specimens were collected from participants, and their immunity status was determined through competitive ELISA, microneutralization assay and enzyme-linked FluoroSpot assay. A total of 272 subjects were involved in the questionnaire survey, of whom 235 (86.4%) were returning Chinese individuals and 37 (13.6%) were foreigners. …”

Image_1_Femtosecond laser-assisted arcuate keratotomy for the management of corneal astigmatism in patients undergoing cataract surgery: Comparison with conventional cataract surge... by Hyunmin Ahn (3821782)

“…</p>Design<p>Retrospective comparative interventional case series.</p>Methods<p>A total of 2,498 eyes of consecutive patients who presented with 3.00 diopters (D) or under of astigmatism were included. …”

Table_1_Chromatin Remodeling Protein ZmCHB101 Regulates Nitrate-Responsive Gene Expression in Maize.xlsx by Xinchao Meng (8444169)

“…Here, we demonstrate that ZmCHB101 plays a pivotal regulatory role in nitrate-responsive gene expression. …”