DataSheet_1_Coexpression of HHLA2 and PD-L1 on Tumor Cells Independently Predicts the Survival of Spinal Chordoma Patients.docx by Chao Xia (1799434)

“…</p>Conclusion<p>These data provide a better understanding of the immunosuppressive mechanism in chordoma and may be useful for the development of combination or novel immunotherapy approaches aiming to improve therapeutic efficacy and survival.…”

Data_Sheet_1_Antioxidant Activity and the Potential Mechanism of the Fruit From Ailanthus altissima Swingle.CSV by Ya-nan Mo (11829002)

“…<p>The fruits of Ailanthus altissima Swingle (AS) possess a variety of pharmacological activities. Its antioxidant activity and the potential mode of action have not yet been investigated. …”

Image_1_Intermittent Fasting Reshapes the Gut Microbiota and Metabolome and Reduces Weight Gain More Effectively Than Melatonin in Mice.tif by Jingliang Liu (1870555)

“…</p><p>Objective: This study aimed to investigate the effects of IF on body fat and the gut microbiota and metabolome as well as a potential interaction with melatonin.</p><p>Methods: Male C57BL/6J mice (23.0 ± 0.9 g, 6 wk old) were randomly assigned into four groups (12 mice/group): control (C), intermittent fasting (F), melatonin (M), and intermittent fasting plus melatonin (MF). …”

Disease-associated mutations in human <i>TUBB3</i> disturb netrin repulsive signaling by Qiangqiang Shao (6866576)

“…<div><p>Missense mutations in the human <i>TUBB3</i> gene cause a variety of neurological disorders associated with defects in axon guidance and neuronal migration, but the underlying molecular mechanisms are not well understood. …”

DataSheet2_Salvia chinensia Benth induces autophagy in esophageal cancer cells via AMPK/ULK1 signaling pathway.ZIP by Lei Jia (303610)

“…<p>Salvia chinensia Benth (Shijianchuan in Chinese, SJC) has been used as a traditional anti-cancer herb. SJC showed good anti-esophageal cancer efficacy based on our clinical application. …”

DataSheet_1_Analysis of Adaptive Olaparib Resistance Effects on Cisplatin Sensitivity in Triple Negative Breast Cancer Cells.docx by Ambikai Gajan (3437534)

“…OlaR TNBC cells express decreased levels of PARP-1 and Pol η, a translesion-synthesis polymerase important in platinum-induced interstrand crosslink repair. …”

Image_2_Deletion of Non-histidine Domains of Histidine Kinase CHK1 Diminishes the Infectivity of Candida albicans in an Oral Mucosal Model.TIF by Yahui Feng (3897082)

“…</p>Methods<p>The domain mutants CHK25 (^ΔS_TkcCHK1/Δchk1) and CHK26 (^ΔS_TkcΔgafCHK1/Δchk1) were first constructed by the his1-URA3-his1 method and confirmed by sequencing and Southern blots. A mouse tongue infection model was used to evaluate the hyphal invasion and fungal loads in each domain mutant, full-gene deletion mutant CHK21 (chk1Δ/chk1Δ), re-constituted strain CHK23 (chk1Δ/CHK1), and wild type (WT) from day 1 to day 5. …”

Data_Sheet_2_Comparison of Calcium Balancing Strategies During Hypothermic Acclimation of Tilapia (Oreochromis mossambicus) and Goldfish (Carassius auratus).PDF by Tsung-Yu Han (5710796)

“…This difference can be attributed to alterations in the transportation parameters for Ca²⁺ influx, i.e., maximum velocity (V_max) and binding affinity (1/K_m). There was also a significant difference in the regulation of Ca²⁺ efflux between the two fishes. …”

Table 1_Epidemiological characteristics and trends of pre-hospital emergency care in Handan, China from 2011 to 2024.docx by Feng Tian (121350)

“…The Mann-Kendall (MK) trend test was employed to assess the trends of pre-hospital EMS demand, age distribution and disease occurrence patterns.</p>Results<p>A total of 613,066 pre-hospital EMS cases from 2011 to 2024 met inclusion criteria. …”

Table_1_Properdin inhibition ameliorates hepatic ischemia/reperfusion injury without interfering with liver regeneration in mice.docx by Jiro Kusakabe (16382577)

“…Western blot showed decreased phosphorylation of only Erk1/2 among MAPKs (P =0.004). …”

DataSheet1_Mechanically durable tri-composite polyamide 6/hematite nanoparticle/tetra-n-butylammonium bromide (PA6/α-Fe2O3/TBAB) nanofiber based membranes for phosphate remediation... by Yun Young Choi (5575382)

“…<p>Essential properties for a Point of Use (POU) water filter include maintaining high removal capacity and rate, with excellent mechanical properties to withstand pressure drop. …”

Image_1_Comprehensive Proteomic Profiling of Urinary Exosomes and Identification of Potential Non-invasive Early Biomarkers of Alzheimer’s Disease in 5XFAD Mouse Model.tif by Zhiqi Song (8684007)

“…</p>Methods<p>Proteomic, bioinformatics analysis, multiple reaction monitoring (MRM), western blotting (WB) or ELISA were performed for analyzing these urinary exosomes.</p>Results<p>A total of 316 proteins including 44 brain cell markers were identified using liquid chromatography tandem mass spectrometry. …”

Table_2_Impact of inhibition of the renin-angiotensin system on early cardiac and renal abnormalities in Sprague Dawley rats fed short-term high fructose plus high salt diet.DOCX by Sharif Hasan Siddiqui (12012206)

“…Introduction<p>The combination of a high fructose and high salt diet typical of western diet induces high blood pressure, aortic stiffening, left ventricular (LV) diastolic dysfunction and impaired renal function in rodents. …”

Effect of SILD on cardiac hypertrophy and macrophage infiltration. by Mary Anna Venneri (737094)

“…<p>(A) Representative photomicrographs of H&E-stained heart from CTRL, SILD, STZ and STZ+SILD mice on harvesting (bar represents 100μm).…”

Image_1_JAK2V617F Mutation Promoted IL-6 Production and Glycolysis via Mediating PKM1 Stabilization in Macrophages.tif by Rongqing Li (2253712)

“…<p>A substitution mutation of valine to phenylalanine at codon encoding position 617 of the Janus kinase 2 (JAK2) gene (JAK2^V617F) has been detected in myeloid cells of some individuals with higher levels of proinflammatory cytokine production such as interleukin (IL)-6. …”

Table_1_Screening for potential warning biomarkers in cows with ketosis based on host–microbiota co-metabolism analysis.DOCX by Zhenlong Du (14063571)

“…Lithocholic acid in the plasma was a potential ketosis warning metabolite 7 days before delivery.…”

Data_Sheet_1_Effects of Sacubitril-Valsartan in Heart Failure With Preserved Ejection Fraction in Patients Undergoing Peritoneal Dialysis.pdf by Sha Fu (445944)

“…Signs and symptoms of heart failure (21/21 vs. 15/21, P = 0.021) were obviously alleviated, NYHA classification and E/e' ratio showed a notable trend of improvement after 3–12 months of follow-up. …”

DataSheet1_Non-Invasive Quantification of Layer-Specific Intrinsic Fluorescence From Mucosa of the Uterine Cervix Using Monte-Carlo-Based Models.docx by Guo-Sheng Lin (11334903)

“…Compared to conventional one-layer forward models, the proposed two-layer models showed significantly smaller errors both in tissue properties estimated from simulated spectra, and in spectral errors of fitting to in-vivo data. Results of a preliminary in-vivo study showed that in seven of eight subjects with histopathologically confirmed dysplasia, the NADH-to-collagen intrinsic fluorescence ratio estimated from the biopsied site was at least two times greater than that estimated from the normal site on the same subject. …”

DataSheet_1_SLAMF8 Downregulates Mouse Macrophage Microbicidal Mechanisms via PI3K Pathways.pdf by Salvador Romero-Pinedo (4922953)

“…Therefore, in conclusion, SLAMF8 intervention upon bacterial infection downregulates mouse macrophage activation, and confirmed that SLAMF8 receptor could be a potential therapeutic target for the treatment of severe or unresolved inflammatory conditions.…”

Image_6_Global, regional, and national years lived with disability due to blindness and vision loss from 1990 to 2019: Findings from the Global Burden of Disease Study 2019.TIF by Shasha Li (139491)

“…Purpose<p>This study aimed to provide a comprehensive assessment of burden estimates and the secular trend of blindness and vision loss, as measured by years lived with disability (YLDs), at the global, regional, and national levels.…”