Image_9_Phenotypic changes of γδ T cells in Plasmodium falciparum placental malaria and pregnancy outcomes in women at delivery in Cameroon.jpeg by Chris Marco Mbianda Nana (14492776)

“…This study sought to investigate the involvement of γδ T cells and its subsets in placental Plasmodium falciparum malaria.</p>Methods<p>In a case-control study conducted in Yaoundé, Cameroon from March 2022 to May 2023, peripheral, placental and cord blood samples were collected from 50 women at delivery (29 PM negative: PM- and 21 PM positive: PM+; as diagnosed by light microscopy). …”

Image_2_Organelle Crosstalk Regulators Are Regulated in Diseases, Tumors, and Regulatory T Cells: Novel Classification of Organelle Crosstalk Regulators.tif by Ming Liu (105953)

“…<p>To examine whether the expressions of 260 organelle crosstalk regulators (OCRGs) in 16 functional groups are modulated in 23 diseases and 28 tumors, we performed extensive -omics data mining analyses and made a set of significant findings: (1) the ratios of upregulated vs. downregulated OCRGs are 1:2.8 in acute inflammations, 1:1 in metabolic diseases, 1:1.2 in autoimmune diseases, and 1:3.8 in organ failures; (2) sepsis and trauma-upregulated OCRG groups such as vesicle, mitochondrial (MT) fission, and mitophagy but not others, are termed as the cell crisis-handling OCRGs. …”

Image_2_Gender- and Age-Associated Differences in Bone Marrow Adipose Tissue and Bone Marrow Fat Unsaturation Throughout the Skeleton, Quantified Using Chemical Shift Encoding-Base... by Kerensa M. Beekman (12467511)

“…<p>Bone marrow adipose tissue (BMAT) is a dynamic tissue which is associated with osteoporosis, bone metastasis, and primary bone tumors. …”

DataSheet_1_TLR2/TLR4-Enhanced TIPE2 Expression Is Involved in Post-Hemorrhagic Shock Mesenteric Lymph-Induced Activation of CD4+T Cells.doc by Hui-Bo Du (11461921)

“…</p>Conclusion<p>TIPE2 improves the PHSML-mediated CD4⁺T cells dysfunction by regulating TLR2/TLR4 pathway, providing a new intervention target following hemorrhagic shock-induced immune dysfunction.…”

Table4_The correlation between Diabetes and age-related degeneration and the static and dynamic 3D mechanical distribution of different plantar regions.docx by Xiong-gang Yang (6085205)

“…</p>Materials and methods<p>A total of 20 HY adults, 16 HO adults and 15 diabetic patients were included. …”

γδ T cells have similar TCR threshold but enhanced ERK1/2 phosphorylation comparing to αβ T cells. by Hsin-Yuan Cheng (414160)

“…<p>(A) Percentages of BrdU⁺ proliferative cells are higher in the γδ T cell subset <i>in vivo</i>. …”

Data_Sheet_1_City-level meteorological conditions modify the relationships between exposure to multiple air pollutants and the risk of pediatric hand, foot, and mouth disease in th... by Wennian Cai (16523583)

“…</p>Methods<p>For each of the 17 cities in the Sichuan Basin, we obtained estimates of the relationship between exposures to multiple air pollutants and childhood HFMD risk by using a unified distributed lag nonlinear model (DLNM). …”

Data_Sheet_1_Anti-hyperuricemic and Anti-inflammatory Effects of Marantodes pumilum as Potential Treatment for Gout.docx by Eldiza Puji Rahmi (8584506)

“…The anti-hyperuricemic activity was initially assessed by XO inhibition with a spectrophotometric in vitro assay. The most active extract was further investigated on hyperuricemic rat model induced by potassium oxonate to determine serum uric acid levels and liver XO effect. …”

<i>Hirsutella sinensis</i> Attenuates Aristolochic Acid-Induced Renal Tubular Epithelial-Mesenchymal Transition by Inhibiting TGF-β1 and Snail Expression by Xiao-yi Xu (2150326)

“…These results suggest Snail might be a potential target of HS effect.</p><p>Conclusion</p><p>HS is able to antagonize, to some extent, tubular EMT and renal interstitial fibrosis caused by AA, which might be related to its inhibitory effects on the TGF-β1 and Snail expression.…”

Synthesis and Pharmacological Evaluation of Different Piperine Analogs for Therapeutic Potential to Prevent ER Stress by Hammad, Ayat Samir

“…Our findings indicate that exposure to tunicamycin (0.5 µg/mL) for 2 hours induces the expression of GRP78 and CHOP, and causes a significant reduction in renal cell viability. …”
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DataSheet_1_Suppression of microRNA-222-3p ameliorates ulcerative colitis and colitis-associated colorectal cancer to protect against oxidative stress via targeting BRG1 to activat... by Xue-jun Wang (280169)

“…Recent studies have indicated that microRNA-222-3p (miR-222-3p) is increased in colon of UC and colorectal cancer (CRC) patients, and miR-222-3p is a crucial regulator of oxidative stress. However, whether miR-222-3p influences IEC oxidative stress in UC and CAC remains unknown. …”

Data Sheet 1_Environmental surveillance of the health risk of PM2.5-bound metals and metalloids in Wuxi, China, from 2020 to 2023.docx by Lijun Chen (313408)

“…<p>PM_2.5 has been a major public concern due to its association with various diseases; however, its contamination is still not well controlled. …”

Data_Sheet_1_RNA sequencing-based identification of the regulatory mechanism of microRNAs, transcription factors, and corresponding target genes involved in vascular dementia.PDF by Kaiyue Zhao (11795684)

“…Five miRNAs (miR-5132-5p, miR-764-3p, miR-223-3p, miR-145-5p, and miR-122-5p), ten TFs (Mxi1, Nfatc4, Rxrg, Zfp523, Foxj2, Nkx6-1, Klf4, Klf5, Csrnp1, and Prdm6), and seven target genes (Serpine1, Nedd4l, Pxn, Col1a1, Plec, Trip12, and Tpm1) were chosen as the significant nodes to construct feed-forward loops (FFLs). …”

Sleep phenotypes of flies with <i>dbt</i> down regulation only during adulthood. by Jialin Wang (490082)

“…<p>(A) Sleep profile of flies with adult specific reduction of <i>dbt</i> level. …”

Identification of RE-1-containing genes potentially involved in beta cell survival. by David Martin (3178)

“…<p><i>A</i>. Alignment of identified RE-1 sequences in human (hum) or murine (mus) genes with the consensus RE-1. …”

Information S1 - Hypoxia Increases Gefitinib-Resistant Lung Cancer Stem Cells through the Activation of Insulin-Like Growth Factor 1 Receptor by Akiko Murakami (515972)

“…Treatment with YC-1 significantly decreased the number of HIF1α-positive cells in a dose-dependent manner. …”

Activity of Major Neural Networks and Hypothesized Molecular Processes Occurring During Wake, NREM Sleep, and REM Sleep by Emmanuel Mignot (31065)

“…</p> <p>(A) Wakefulness. During wakefulness, monoaminergic, hypocretinergic, and cholinergic systems are active and contribute to EEG desynchronization through thalamic and cortical projections. …”

CD4 T-cell expression of IFN-γ and IL-17 in pediatric malarial anemia by Evans Raballah (3937781)

“…In addition, circulating IFN-γ and IL-17 were measured as part of a Cytokine 25-plex Antibody Bead Kit, Human (BioSource™ International). …”

Data_Sheet_1_Effects of Dietary Yucca Schidigera Extract and Oral Candida utilis on Growth Performance and Intestinal Health of Weaned Piglets.docx by Zhenguo Yang (786974)

“…The purpose of this study was to explore the effects of dietary yucca schidigera extract (YSE) and oral Candida utilis (CU) on growth performance and intestinal health weaned piglets. According to a 2 × 2 factorial design with the main factors being CU (orally administered 1 mL of 0.85% saline with or without CU; fed basal diet with or without 120 mg/kg YSE), forty 28 d healthy weaned piglets were randomly allocated into four groups of 10 barrows each: (1) piglets fed basal diet and orally administered 1 mL of 0.85% saline (CON); (2) piglets fed basal diet and orally administered 1 mL 1 × 10⁹ cfu/mL C. utilis in 0.85% saline (CU); (3) piglets fed the basal diet containing YSE (120 mg/kg) and orally administered 1 mL of 0.85% saline (YSE); (4) Piglets fed the basal diet containing 120 mg/kg YSE and 1 mL 1 × 10⁹ cfu/mL C. utilis in 0.85% saline (YSE+CU). …”

Contributions of direct versus indirect mechanisms for regulatory dendritic cell suppression of asthmatic allergen-specific IgG1 antibody responses by Yanna Ma (4730493)

“…Herein we assessed the mechanism(s) by which DC10 and DC10-induced Treg affect IgG1 production in asthma. We observed a rapid decline in lung-resident OVA-specific IgG1-secreting B cells on cessation of airway allergen challenge, and intraperitoneal DC10 therapy did not amplify that (p>0.05). …”