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27001
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27002
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27003
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27004
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27006
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27007
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27008
CircRNA protein tyrosine phosphatase receptor type a suppresses proliferation and induces apoptosis of lung adenocarcinoma cells via regulation of microRNA-582-3p
Published 2022“…The sites of circRNA_PTPRA/miR-582-3p interaction were identified using StarBase, and validated using a dual-luciferase reporter assay. We observed that circRNA_PTPRA levels were remarkably decreased, and miR-582-3p expression was up-regulated in lung cancer tissues and cells. circRNA_PTPRA directly interacts with miR-582-3p and downregulates miR-582-3p expression in lung cancer cells. …”
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27009
Model correctly predicts the ATP fractions in KaiC nucleotide binding pockets and the phase difference between this fraction and the phosphorylation level.
Published 2017“…KaiA increases the nucleotide exchange rate in the CII domain, and the resultant high phosphorylation level decreases the ADP dissociation rate in CI, which decreases the ATP fraction in this domain. …”
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27010
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27011
Correlation analysis of miR-27a/b-3p levels with disease severity and duration.
Published 2020“…<p><b>(A)</b> PBMCs derived miR-27a-3p level decreased along with the disease severity. …”
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27012
Inhibiting Gamma-secretase activity without interfering in Notch signaling: Decreasing the inflammatory response in patients with cutaneous leishmaniasis
Published 2020“…</b>Monocytes from HS (n= 5) were infected with <i>L. braziliensis</i>in stationary phase (ratio 5:1) and cultured in presence or absence of JLK6 (20µM) for 2, 48 and 72 hours. (A) Frequency of infected cells. (B) Number of <i>Leishmania </i>amastigotes/100 monocytes. …”
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27013
The Actin Targeting Compound Chondramide Inhibits Breast Cancer Metastasis via Reduction of Cellular Contractility
Published 2014“…On the signaling level, RhoA activity is decreased by Chondramide accompanied by reduced MLC-2 and the stretch induced guanine nucleotide exchange factor Vav2 activation. …”
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27014
Image_2_Tumor Suppressor miR-184 Enhances Chemosensitivity by Directly Inhibiting SLC7A5 in Retinoblastoma.TIF
Published 2019“…Molecular studies revealed that miR-184-decreased phosphorylation status of known DNA damage repair sensors of the ATR/ATM pathways and induced persistent formation of γH2AX foci depend on targeting SLC7A5, leading to persistent DNA damage. …”
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27015
Table_1_Cardiotonic Pills Plus Recombinant Human Prourokinase Ameliorates Atherosclerotic Lesions in LDLR–/– Mice.DOCX
Published 2019“…No effect was observed for proUK alone on any endpoints tested. CP plus proUK induced a significantly reduction in the atherosclerotic lesions, along with decreased levels of total cholesterol, triglyceride in the plasma. …”
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27016
Image_3_Tumor Suppressor miR-184 Enhances Chemosensitivity by Directly Inhibiting SLC7A5 in Retinoblastoma.TIF
Published 2019“…Molecular studies revealed that miR-184-decreased phosphorylation status of known DNA damage repair sensors of the ATR/ATM pathways and induced persistent formation of γH2AX foci depend on targeting SLC7A5, leading to persistent DNA damage. …”
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27017
Image_3_Tumor Suppressor miR-184 Enhances Chemosensitivity by Directly Inhibiting SLC7A5 in Retinoblastoma.TIF
Published 2019“…Molecular studies revealed that miR-184-decreased phosphorylation status of known DNA damage repair sensors of the ATR/ATM pathways and induced persistent formation of γH2AX foci depend on targeting SLC7A5, leading to persistent DNA damage. …”
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27018
The roles of miRNA-23a and IL-8 in the radioresistance of NPC cells.
Published 2014“…<p>(A) and (B). A representative clonogenic survival assay shows that transfection of miRNA-23a mimic decreased the radioresistance of NPC CNE2-IR cells. …”
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27019
Image_1_Tumor Suppressor miR-184 Enhances Chemosensitivity by Directly Inhibiting SLC7A5 in Retinoblastoma.TIF
Published 2019“…Molecular studies revealed that miR-184-decreased phosphorylation status of known DNA damage repair sensors of the ATR/ATM pathways and induced persistent formation of γH2AX foci depend on targeting SLC7A5, leading to persistent DNA damage. …”
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27020
The phosphorylation state of the CII domain regulates the ADP fraction in the CI domain by changing the ADP release rate, but not its affinity.
Published 2017“…<p>(A) Cartoon that illustrates why the experiments rule out the latter “affinity” scenario. …”