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larger decrease » marked decrease (Expand Search)
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large decrease » marked decrease (Expand Search), large increases (Expand Search), large degree (Expand Search)
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Structural Insights into the Role of the Stereochemistry of the Cyclopropyl Ring in the Inhibitory Activity of Xeruborbactam against SME‑1 Class A Carbapenemase
Published 2025“…Although both inhibitors bind covalently to Ser70 in SME-1, the 2<i>R</i>,3<i>S</i>-isomer adopts a different conformation of the cyclopropyl ring, which makes the C3 carbon much farther from His105, Asn132, and Lys73, thereby decreasing the binding affinity and <i>K</i><sub>i</sub>(app) of the isomer. …”
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Phenotype and molecular identification of <i>GmNN1/FT2a</i> in stable transgenic soybean plants.
Published 2022Subjects: -
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Structural Insights into the Role of the Stereochemistry of the Cyclopropyl Ring in the Inhibitory Activity of Xeruborbactam against SME‑1 Class A Carbapenemase
Published 2025“…Although both inhibitors bind covalently to Ser70 in SME-1, the 2<i>R</i>,3<i>S</i>-isomer adopts a different conformation of the cyclopropyl ring, which makes the C3 carbon much farther from His105, Asn132, and Lys73, thereby decreasing the binding affinity and <i>K</i><sub>i</sub>(app) of the isomer. …”
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A Customized Pigmentation SNP Array Identifies a Novel SNP Associated with Melanoma Predisposition in the <em>SLC45A2</em> Gene
Published 2011“…Furthermore, individuals carrying two or more mutations in <em>MC1R</em>, a well-known low penetrance melanoma-predisposing gene, had a decreased MM risk if concurrently bearing the <em>SLC45A2</em> protective variant. …”