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Presentation 1_Decreased brain-derived neurotrophic factor expression in chronic kidney disease: integrated clinical and experimental evidence.pptx
Published 2025“…</p>Conclusion<p>This study integrated meta-analysis, murine model validation, and single-cell transcriptomic profiling to demonstrate a significant reduction of BDNF in CKD. Furthermore, renal BDNF expression decreased locally, predominantly originating from proximal tubule cells, macrophages, and podocytes, possibly epigenetically inhibited by the upregulation of lnc RNA Bdnf-as.…”
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Ablation of SGK1 Impairs Endothelial Cell Migration and Tube Formation Leading to Decreased Neo-Angiogenesis Following Myocardial Infarction
Published 2013“…Ablation of SGK1 in these mice caused a significant decrease in phosphorylation of SGK1 target protein NDRG1, which correlated with alterations in NF-κB signalling and expression of its downstream target protein, VEGF-A. …”
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Validation of primary screen hits reveals compounds that recapitulate increased spheroid size (swell) or decreased MUC5AC in the lumen.
Published 2023“…Compounds that appeared to cause toxicity were identified by observing a significant decrease in spheroid counts in the swell readout or a significant decrease in the total nuclear intensity of the MUC5AC ratio readout. …”
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30537
<i>sod-sod</i> Double Deletion Mutants Do Not Exhibit Decreased Lifespan Despite Increased Sensitivity to Oxidative Stress.
Published 2009“…<p>A) None of the <i>sod-1</i> double deletion mutants showed a decreased lifespan compared to wild-type or <i>sod-1</i> mutant worms. …”
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Decreased GATA-4 levels cause reduced expression of claudin-2, ZO-3 and claudin-3 in double-KD cells.
Published 2013“…<p>(<b>A</b>) qRT-PCR analysis of the mRNA levels of GATA-4 in the different MDCK cell clones. …”