A Novel Potent Anticancer Compound Optimized from a Natural Oridonin Scaffold Induces Apoptosis and Cell Cycle Arrest through the Mitochondrial Pathway by Shengtao Xu (513564)

“…Furthermore, <b>13p</b> induced apoptosis and cell cycle arrest at the G2/M phase. A decrease in mitochondrial membrane potential and an increase in Bax/Bcl-2 ratio, accompanied by activated caspase-3 cleavage, were observed in MCF-7 cells after treatment with <b>13p</b>, suggesting that the mitochondrial pathway was involved in the <b>13p</b>-mediated apoptosis. …”

Data_Sheet_1_Antimicrobial Peptides Derived From Insects Offer a Novel Therapeutic Option to Combat Biofilm: A Systematic Review.docx by Alaka Sahoo (10951611)

“…Besides, AMPs may well act synergistically with classical antibiotics for a double-pronged attack on infections. Thus, AMPs could be promising alternatives to overcome medically important biofilms, decrease the possibility of acquired resistance and treatment of multidrug-resistant pathogens including ESKAPE. …”

The <i>Kdm6a</i>-null stroma promotes the expression of <i>Kdm6a-</i>null hematopoietic stem and progenitor cells. by Ling Tian (107492)

“…(D) Quantification of the indicated progenitor compartments showed an increase in GMPs and a decrease in MEPs in cohort 1 as compared to all other cohorts. …”

Supplementary Material for: Efficacy and Safety of a Persian Medicine Formula on Functional Dyspepsia Symptoms: A Randomized Double-blind Active-control Clinical Trial by Azimi M. (14520728)

“…The intra-group analysis showed a significant decrease in the symptoms severity and frequency at the end of week 4 in both groups (P<0.001). …”

Table_1_A Mutation in VWA1, Encoding von Willebrand Factor A Domain-Containing Protein 1, Is Associated With Hemifacial Microsomia.DOCX by Yibei Wang (5321825)

“…Knockdown/knockout studies of the zebrafish revealed deformities of pharyngeal cartilage. A decrease of the proliferation of cranial neural crest cells (CNCCs) and alteration of the structure of pharyngeal chondrocytes were observed in the morphants as well.…”

let-7a and let-7b expression are altered <i>in vitro</i> in response to genotoxic stress in a p53 dependent manner. by Anthony D. Saleh (342299)

“…Cells were then treated with etoposide, H₂O₂, or UV radiation and assessed for let-7a (C) and let-7b (D). These genotoxic stressors similarly resulted in a decrease of both let-7 species that was observed only in the p53^+/+ cells. …”

Data_Sheet_4_Why Is a High Temperature Needed by Thermus thermophilus Argonaute During mRNA Silencing: A Theoretical Study.ZIP by Ye Liu (1257897)

“…The simulation results indicate that a collapse of a small β-strand (residues 507–509) at 310 K caused Glu512 to move away from the catalytic residues Asp546 and Asp478, resulting in a decrease in catalytic activity, which was not observed in the simulations at 324 and 338 K. …”

Assessing the Effect of an Integrated Control Strategy for Schistosomiasis Japonica Emphasizing Bovines in a Marshland Area of Hubei Province, China: A Cluster Randomized Trial by Xi-Cheng Hong (389589)

“…In contrast, there were no statistically significant reductions of <i>S. japonicum</i> infection in humans, bovines and snails from 2008 to 2011 in the control group (P>0.05 for all comparisons). Moreover, a generalized linear model showed that there was a higher infection risk in humans in the control group than in the intervention group (OR = 1.250, P = 0.001) and an overall significant downward trend in infection risk during the study period.…”

Analysis of the posttranslational modifications of the class II pilin expressing strain FAM20. by Joseph Gault (427444)

<i>Neisseria meningitidis</i> Type IV Pili Composed of Sequence Invariable Pilins Are Masked by Multisite Glycosylation by Joseph Gault (427444)

“…In the human pathogen <i>Neisseria meningitidis</i>, strains expressing class I pilins contain a genetic recombination system that promotes variation of the pilin sequence and is thought to aid immune escape. …”

Apoptosis induction, caspase-8 cleavage, and the decrease in c-FLIP levels due to DX1 treatment in NB4, HP100-1 and K562 cells. by Zhiying Yu (356965)

Table_1_Milled rapeseeds and oats decrease milk saturated fatty acids and ruminal methane emissions in dairy cows without changes in product sensory quality.docx by Anni Halmemies-Beauchet-Filleau (14683582)

“…The milk fat saturated FAs were decreased by 16%–20% in the test diet, mainly due to the de novo FAs of 6- to 16-carbons (a reduction of 22%–48%). …”

Electron Distribution in the Nonclassical Bis(dithiolene) Electron Transfer Series [M(CO)₂(S₂C₂Me₂)₂]^0/1-/2- (M =... by Dmitry V. Fomitchev (2962923)

“…The trends in parameters involving the carbonyl groups provide a particularly clear indication of the classical behavior of a π-acceptor ligand in isostructural molecules subject to consecutive reductions over three oxidation states.…”

Trial profile. by Chanel Avenant (409756)

“…We investigated the effects of these progestin-only injectable contraceptives on serum testosterone and sex hormone binding globulin (SHBG) levels, since these may play a role in sexual behavior and HIV acquisition. …”

Illustration of the experimental protocol used in this study where nine biathletes (experts) and eight cross-country skiers (novices) performed 100 shots in rest (NOPA-condition) a... by Harri Luchsinger (3178887)

Table_1_North American Propolis Extracts From Upstate New York Decrease Nosema ceranae (Microsporidia) Spore Levels in Honey Bees (Apis mellifera).xlsx by Andre J. Burnham (9149522)

“…<p>Nosema ceranae infections in honey bees (Apis mellifera) pose a severe threat to colony health. Beekeepers have used dicyclohexylammonium fumagillin to control Nosema apis, although it may be ineffective against N. ceranae. …”

Table_1_The Relationship Between Defense Mechanisms and Attachment as Measured by Observer-Rated Methods in a Sample of Depressed Patients: A Pilot Study.docx by Vera Békés (9603860)

“…Moreover, as expected, early-phase defense use was related to late phase attachment; specifically, early neurotic and immature Depressive and Non-depressive defenses predicted an increase in avoidant, whereas immature Non-depressive defenses predicted a decrease in preoccupied attachment-related characteristics over the course of treatment, after controlling for early attachment effects. …”

Table_1_Benefit of Physiologically Variable Over Pressure-Controlled Ventilation in a Model of Chronic Obstructive Pulmonary Disease: A Randomized Study.DOCX by Andre Dos Santos Rocha (9980156)

“…Introduction<p>The advantages of physiologically variable ventilation (PVV) based on a spontaneous breathing pattern have been demonstrated in several respiratory conditions. …”

Table_2_Soil metatranscriptome demonstrates a shift in C, N, and S metabolisms of a grassland ecosystem in response to elevated atmospheric CO2.XLSX by David Rosado-Porto (11935367)

“…In addition, N cycle changes included a decrease in the transcript abundance of N₂O reductase, involved in the last step of the denitrification process, which explains the increase of N₂O emissions in the Gi-FACE. …”

Table_3_Soil metatranscriptome demonstrates a shift in C, N, and S metabolisms of a grassland ecosystem in response to elevated atmospheric CO2.DOCX by David Rosado-Porto (11935367)

“…In addition, N cycle changes included a decrease in the transcript abundance of N₂O reductase, involved in the last step of the denitrification process, which explains the increase of N₂O emissions in the Gi-FACE. …”