IODVA1, a guanidinobenzimidazole derivative, targets Rac activity and Ras-driven cancer models by Anjelika Gasilina (8566296)

“…<div><p>We report the synthesis and preliminary characterization of IODVA1, a potent small molecule that is active in xenograft mouse models of Ras-driven lung and breast cancers. …”

Use of Thiopurines and Risk of Colorectal Neoplasia in Patients with Inflammatory Bowel Diseases: A Meta-Analysis by Jianfeng Gong (177593)

“…The use of thiopurines was associated with a statistically significant decreased incidence of colorectal neoplasm (summary RR=0.71, 95% CI=0.54–0.94, p=0.017), even after adjustment for duration and extent of the disease, but there was high heterogeneity among studies (<i>I</i>²=68.0%, p<0.001). …”

Clinical value of thalidomide on kk-rat model through TNF-a mediated inflammation approach by Min HUANG (12728997)

“…The levels of TNF-α, IL-1β, interleukin -6 (IL-6) and interleukin -18 (IL-18) of kk-Ay in the thalidomide group and the model control group were both at a higher level before treatment, but the difference was not statistically significant (P >0.05); The levels of TNF-α, IL-1β, interleukin -6 (IL-6) and interleukin -18 (IL-18) in kk-Ay rats 8/10/12 weeks after the treatment in the thalidomide group were significantly decreased, with statistically significant differences compared with the model control group (P < 0.05). …”

Table_2_Genetic Adaptation of a Mevalonate Pathway Deficient Mutant in Staphylococcus aureus.DOCX by Sebastian Reichert (553783)

“…<p>In this study we addressed the question how a mevalonate (MVA)-auxotrophic Staphylococcus aureusΔmvaS mutant can revert to prototrophy. …”

Supplementary Material for: Long-Term Outcomes of Developmental Exposure to Fluoxetine: A Review of the Animal Literature by Kiryanova V. (4142347)

“…An estimated 1.4-2.1% of pregnant women use this medication, which inhibits the reuptake of serotonin and thereby increases serotonergic activity at the synapse. Serotonin acts as a cue guiding numerous neurodevelopmental processes, and changes in the concentration of serotonin can disrupt normal in utero brain development and organization in humans and other animals, thus providing a mechanism by which maternal intake of FLX might alter neural development and ultimately behaviour. …”

Recreational Use of the Countryside: No Evidence that High Nature Value Enhances a Key Ecosystem Service by Karen Hornigold (3339594)

“…Models were based on a massive, three year national household survey providing spatially-referenced recreational visits to the natural environment. …”

Establishment of a yeast essential protein conditional-degradation library and screening for autophagy-regulating genes by Yi Zhang (9093)

“…In summary, the yeast essential protein conditional degradation library we constructed will serve as a valuable resource for systematically investigating the roles of essential genes in autophagy and other biological functions.…”

<i>NEXN</i> Is a Novel Susceptibility Gene for Coronary Artery Disease in Han Chinese by Chong Wu (130393)

“…Further eQTL analysis demonstrated that the risk allele T of rs1780050 is associated with decreased expression of NEXN, thus contributing to a higher risk of CAD susceptibility in the population. …”

Mesomorphic properties of cyanobiphenyl dimers with a substituted central malonate unit: overruling effect of fluorination by Marco André Grunwald (5425064)

“…In case of C2-hexyl-substituted dimers, shorter spacers favoured N phases (n = 6–9), while longer spacers favoured SmA phases (n ≥ 9). In addition, decreased clearing temperatures were observed. …”

Failure of Passive Immune Transfer in Calves: A Meta-Analysis on the Consequences and Assessment of the Economic Impact by Didier Raboisson (2833616)

“…Neither a quantitative analysis of FPT consequences nor an assessment of its total cost are available. …”

Table_2_Oxytocin predicts positive affect gains in a role-play interaction.docx by Alexandru I. Berceanu (9241328)

“…</p>Results<p>In our experiment, role-play significantly increased positive affect and prosocial attitudes and decreased anxiety compared to a control condition. …”

<i>her8a</i> is regulated by the Su(H)-dependent Notch signaling pathway. by Pei-Chen Chung (223912)

“…(I) The levels of <i>her8a</i> expression in <i>Su(H)</i> variant injected embryos were further quantified by qPCR, showing significantly increased <i>her8a</i> expression in <i>ANK</i> injected embryos and decreased expression in <i>DBM</i> over-expressed embryos. …”

Supplementary Material for: Dementia with grains, a clinical mimic of dementia with Lewy bodies - Case Report by figshare admin karger (2628495)

“…These symptoms in combination with decreased striatal uptake of tracer on a 123I-FP-CIT-SPECT scan led to the clinical diagnosis of probable mild dementia with Lewy bodies. …”

Prevalence of xerostomia and its association with systemic diseases and medications in the elderly: a cross-sectional study by Cindel Balbinot Fornari (12800583)

“…Its origins are multicausal and might be the result of a change in the salivary glands or a systemic imbalance. …”

Effect of acetylcholinesterase inhibitors on post-stroke cognitive impairment and vascular dementia: A meta-analysis by Jin Ok Kim (8422956)

“…<div><p>Cognitive impairment is a common complication observed after a stroke. …”

Table_9_Effects of Taurine on Primary Metabolism and Transcription in a Coral Symbiodinium sp..xlsx by Aiyou Huang (404014)

“…The results revealed that taurine significantly increased the growth, photosynthesis efficiency, total soluble sugar, chlorophyll a, and chlorophyll b and free amino acid content of Symbiodinium sp. while decreased the content of total insoluble sugar. …”

Glomerular endothelial derived vesicles mediate podocyte dysfunction: A potential role for miRNA by N. Hill (8626446)

“…However, little is known about how extracellular signals from the glomerular microenvironment regulate podocyte activity. Using a non-contact transwell system, communication between glomerular endothelial cells (GEnC) and podocytes was characterised <i>in-vitro</i>. …”

Table_4_Genetic Adaptation of a Mevalonate Pathway Deficient Mutant in Staphylococcus aureus.XLSX by Sebastian Reichert (553783)

“…<p>In this study we addressed the question how a mevalonate (MVA)-auxotrophic Staphylococcus aureusΔmvaS mutant can revert to prototrophy. …”

Image_3_Genetic Adaptation of a Mevalonate Pathway Deficient Mutant in Staphylococcus aureus.PDF by Sebastian Reichert (553783)

“…<p>In this study we addressed the question how a mevalonate (MVA)-auxotrophic Staphylococcus aureusΔmvaS mutant can revert to prototrophy. …”

P-glycoprotein (P-gp) expression of K562/A02 cell line by 0 by Baoan Chen (53879)

“…1 FeO-MNPs loaded with different concentrations of Tet (the polymerization condition: 4 °C, 48 h). () The mouse isotype-matched IgG2a-PE was used as negative control, P-gp was 2.61%. () ~() The monoclonal antibody (MoAb) P-gp-PE was applied in detecting P-gp. () The total expression P-gp of K562/A02 was 99.95%. () Merely 0.1 FeO-MNPs were incubated with cells, P-gp was 99.88% with no change. () Merely Tet (10 μmol/l 1) were incubated with cells, P-gp was significantly decreased to 76.37%. () FeO-MNPs loaded with low concentration of Tet (1 μmol/l 1), P-gp was 99.71% with no obvious change. () FeO-MNPs loaded with high concentration of Tet (10 μmol/l 1), P-gp was 99.69% with no obvious change.…”