Unsuspected osteochondroma-like outgrowths in the cranial base of Hereditary Multiple Exostoses patients and modeling and treatment with a BMP antagonist in mice by Sayantani Sinha (716150)

“…<div><p>Hereditary Multiple Exostoses (HME) is a rare pediatric disorder caused by loss-of-function mutations in the genes encoding the heparan sulfate (HS)-synthesizing enzymes EXT1 or EXT2. …”

Temporal trends in adolescents’ self-reported psychosomatic health complaints from 1980-2016: A systematic review and meta-analysis by Thomas Potrebny (4624135)

“…In the descriptive analysis, 10 studies indicated a trend of increasing PSHC, eight showed a stable trend and three showed a decreasing trend at certain points in time. …”

Table_1_Inflammatory cytokines and stroke and its subtypes: a genetic correlation and two-sample Mendelian randomization study.XLSX by Yu Guo (102701)

“…Our findings suggest that decreased IL-17 levels could potentially be linked to a higher likelihood of intracerebral hemorrhage (ICH) (OR = 0.51, 95% CI: 0.28–0.93, p = 0.028). …”

Mechanical effects of MitraClip on leaflet stress and myocardial strain in functional mitral regurgitation – A finite element modeling study by Yue Zhang (30585)

“…As device-induced mechanical effects are a potential cause for MR recurrence, we tested the hypothesis that MitraClip increases leaflet stress and procedure-related strain in sub-valvular left ventricular (LV) myocardium in FMR associated with coronary disease (FMR-CAD).…”

Table_7_Dried fruit intake causally protects against low back pain: A Mendelian randomization study.DOCX by Jian Huang (7250)

Data_Sheet_1_Independent and Interactive Associations of Fitness and Fatness With Changes in Cardiometabolic Risk in Children: A Longitudinal Analysis.docx by Xianwen Shang (311546)

“…</p><p>Results: There was a high correlation between fatness and CRF in both boys and girls. …”

Microdialysis Assessment of Cerebral Perfusion during Cardiac Arrest, Extracorporeal Life Support and Cardiopulmonary Resuscitation in Rats – A Pilot Trial by Andreas Schober (631954)

“…During VF-CA central nervous glucose decreased (0.32±0.1mmol/l to 0.04±0.01mmol/l; p<0.001) and showed a significant rise (0.53±0.1;p<0.001) after resuscitation. …”

Table_7_Inflammatory cytokines and stroke and its subtypes: a genetic correlation and two-sample Mendelian randomization study.XLSX by Yu Guo (102701)

“…Our findings suggest that decreased IL-17 levels could potentially be linked to a higher likelihood of intracerebral hemorrhage (ICH) (OR = 0.51, 95% CI: 0.28–0.93, p = 0.028). …”

Table_8_Dried fruit intake causally protects against low back pain: A Mendelian randomization study.DOCX by Jian Huang (7250)

Table1_Risk of drug-induced angioedema: a pharmacovigilance study of FDA adverse event reporting system database.xlsx by Maoxia Fan (16914033)

“…After categorizing the drugs, the strongest positive signal was observed in the antithrombotic agents [ROR (95% CI): 22.53 (21.16–23.99)], following that, cardiovascular drugs [ROR (95% CI): 9.17 (8.87–9.48)], antibiotics [ROR (95% CI): 6.42 (5.91–6.96)], immunosuppressors [ROR (95% CI): 5.95 (5.55–6.39)], anti-inflammatory analgesics [ROR (95% CI): 4.65 (4.45–4.86)], antiallergic drugs [ROR (95% CI): 4.47 (3.99–5)], antiasthmatics [ROR (95% CI): 2.49 (2.14–2.89)], blood sugar control drugs [ROR (95% CI): 1.65 (1.38–1.97)], and digestive system drugs [ROR (95% CI): 1.59 (1.45–1.74)] exhibited progressively decreasing ROR values.</p>Conclusion<p>Many medications are associated with a high risk of angioedema. …”

DataSheet1_Daily Variations in pCO2 and fCO2 in a Subtropical Urbanizing Lake.docx by Rongjie Yang (1493281)

“…<p>The transfer of CO₂ from lakes to the atmosphere is a component of the global carbon equilibrium, while the quantification of the CO₂ partial pressure (pCO₂) is critical for exploring the contribution of freshwater CO₂ emissions in the regional/global carbon budget. …”

Table_1_Retinal changes in patients with idiopathic inflammatory myopathies: A case-control study in the MyoCite cohort.docx by Rachna Aggarwal (14193875)

“…Therefore, we explored retinal changes in patients with Idiopathic inflammatory myopathies (IIM) as a surrogate for vascular health.</p>Methods<p>Adult and Juvenile IIM patients (2017 ACR/EULAR criteria), visiting a tertiary care center in 2021 were enrolled for detailed ophthalmic examination in comparison with healthy controls (HC). …”

Resveratrol reduces <i>miR-21</i> expression and increases PDCD4 and maspin expression. <i>A,</i> by Sandeep Sheth (112040)

“…<b><i>B,</i></b> Resveratrol decreases <i>miR-21</i> levels in a dose-dependent manner. …”

Image_1_Negative Association of Interleukin-33 Plasma Levels and Schistosomiasis Infection in a Site of Polyparasitism in Rural Cameroon.TIF by Severin Donald Kamdem (8069741)

“…Although Plasma IL-33 showed a minimal negative risk for schistosomiasis infection (AOR 0.99; 95% CI 0.97–1.01), S. mansoni infected participants had lower levels of plasma IL-33 (p = 0.003) which decreased significantly as eggs burdens increased (p = 0.01) with a negative Pearson coefficient of r = −0.22. …”

Image2_Identification of novel TMEM231 gene splice variants and pathological findings in a fetus with Meckel Syndrome.JPEG by Qian Zhang (49333)

“…The two variants were predicted to be pathogenic by in silico tools and were classified as pathogenic/likely pathogenic variants according to the American College of Medical Genetics and Genomics guideline. cDNA TA cloning analysis showed that both splice site variants caused a deletion of exon 5. RT-PCR revealed that the expression of TMEM231 was significantly decreased and immunofluorescence showed that the primary cilium was almost absent in the proband’s kidney tissue.…”

Table1_Identification of novel TMEM231 gene splice variants and pathological findings in a fetus with Meckel Syndrome.xlsx by Qian Zhang (49333)

“…The two variants were predicted to be pathogenic by in silico tools and were classified as pathogenic/likely pathogenic variants according to the American College of Medical Genetics and Genomics guideline. cDNA TA cloning analysis showed that both splice site variants caused a deletion of exon 5. RT-PCR revealed that the expression of TMEM231 was significantly decreased and immunofluorescence showed that the primary cilium was almost absent in the proband’s kidney tissue.…”

DataSheet1_Prescribing Intensity in Resistance Training Using Rating of Perceived Effort: A Randomized Controlled Trial.XLSX by Yael Boxman-Zeevi (12478485)

“…For instance, trainees can reach a specific RPE value by modifying the number of repetitions, lifted loads, or other training variables. …”

Table2_A Mendelian randomization study for drug repurposing reveals bezafibrate and fenofibric acid as potential osteoporosis treatments.docx by Xiao-Hua Li (1508020)

“…The significant lipid-lowering drugs after MR analyses were further evaluated for their effects on bone mineralization using a dexamethasone-induced OP zebrafish model.</p><p>Results: The first step MR analysis found that the higher expression of four genes (HMGCR, NPC1L1, PCSK9 and PPARG) was significantly associated with a lower LDL-C level. …”

Table_9_Inflammatory cytokines and stroke and its subtypes: a genetic correlation and two-sample Mendelian randomization study.XLSX by Yu Guo (102701)

“…Our findings suggest that decreased IL-17 levels could potentially be linked to a higher likelihood of intracerebral hemorrhage (ICH) (OR = 0.51, 95% CI: 0.28–0.93, p = 0.028). …”

DataSheet1_A Novel Quality-Control Procedure to Improve the Accuracy of Rare Variant Calling in SNP Arrays.docx by Ting-Hsuan Sun (9385940)

“…Using data from the TWB 2.0 custom Axiom array, we adopted an advanced normalization adjustment to prevent false calls caused by splitting the cluster and a rare het adjustment which decreases false calls in rare variants. …”