Table1_A Mendelian randomization study for drug repurposing reveals bezafibrate and fenofibric acid as potential osteoporosis treatments.docx by Xiao-Hua Li (1508020)

“…The significant lipid-lowering drugs after MR analyses were further evaluated for their effects on bone mineralization using a dexamethasone-induced OP zebrafish model.</p><p>Results: The first step MR analysis found that the higher expression of four genes (HMGCR, NPC1L1, PCSK9 and PPARG) was significantly associated with a lower LDL-C level. …”

Data_Sheet_2_Dysbiosis of Gut Microbiota and Short-Chain Fatty Acids in Encephalitis: A Chinese Pilot Study.pdf by Ruoting Xu (6292910)

“…However, few researches were focused on the gut microbiome characteristics in encephalitis patients.</p>Methods<p>A prospective observational study was conducted in an academic hospital in Guangzhou from February 2017 to February 2018. …”

Image_2_RASGRP2 is a potential immune-related biomarker and regulates mitochondrial-dependent apoptosis in lung adenocarcinoma.jpeg by Yongting Liu (13763629)

“…And we constructed a FLI1-HSA-miR-1976-RASGRP2 transcriptional network to support the role of RASGRP2. …”

The relationship of serum vitamins A, D, E and LL-37 levels with allergic status, tonsillar virus detection and immune response by Varpu Elenius (114547)

“…Detection of viruses decreased by age. Higher vitamin A levels showed borderline significance with less viral detection (<i>P</i> = 0.056). …”

Presentation_1_The secretome of macrophages has a differential impact on spinal cord injury recovery according to the polarization protocol.pdf by José Lentilhas-Graça (9412604)

“…Infiltrating macrophages can acquire a spectrum of activation states, however, the microenvironment at the SCI site favors macrophage polarization into a pro-inflammatory phenotype, which is one of the reasons why macrophage transplantation has failed.…”

Table2_Identification of novel TMEM231 gene splice variants and pathological findings in a fetus with Meckel Syndrome.DOCX by Qian Zhang (49333)

“…The two variants were predicted to be pathogenic by in silico tools and were classified as pathogenic/likely pathogenic variants according to the American College of Medical Genetics and Genomics guideline. cDNA TA cloning analysis showed that both splice site variants caused a deletion of exon 5. RT-PCR revealed that the expression of TMEM231 was significantly decreased and immunofluorescence showed that the primary cilium was almost absent in the proband’s kidney tissue.…”

Table_9_Dried fruit intake causally protects against low back pain: A Mendelian randomization study.DOCX by Jian Huang (7250)

Table_1_Tourism experiences reduce the risk of cognitive impairment in the Chinese older adult: a prospective cohort study.DOCX by Qian Li (114642)

“…Cox regression showed that tourism decreased the risk of cognitive impairment (aHR = 0.69, 95% CI: 0.41–0.62) when adjusted for behavioral covariates and characteristics. …”

Table_4_Inflammatory cytokines and stroke and its subtypes: a genetic correlation and two-sample Mendelian randomization study.XLSX by Yu Guo (102701)

“…Our findings suggest that decreased IL-17 levels could potentially be linked to a higher likelihood of intracerebral hemorrhage (ICH) (OR = 0.51, 95% CI: 0.28–0.93, p = 0.028). …”

Image1_Identification of novel TMEM231 gene splice variants and pathological findings in a fetus with Meckel Syndrome.JPEG by Qian Zhang (49333)

“…The two variants were predicted to be pathogenic by in silico tools and were classified as pathogenic/likely pathogenic variants according to the American College of Medical Genetics and Genomics guideline. cDNA TA cloning analysis showed that both splice site variants caused a deletion of exon 5. RT-PCR revealed that the expression of TMEM231 was significantly decreased and immunofluorescence showed that the primary cilium was almost absent in the proband’s kidney tissue.…”

Table2_Risk of drug-induced angioedema: a pharmacovigilance study of FDA adverse event reporting system database.xlsx by Maoxia Fan (16914033)

“…After categorizing the drugs, the strongest positive signal was observed in the antithrombotic agents [ROR (95% CI): 22.53 (21.16–23.99)], following that, cardiovascular drugs [ROR (95% CI): 9.17 (8.87–9.48)], antibiotics [ROR (95% CI): 6.42 (5.91–6.96)], immunosuppressors [ROR (95% CI): 5.95 (5.55–6.39)], anti-inflammatory analgesics [ROR (95% CI): 4.65 (4.45–4.86)], antiallergic drugs [ROR (95% CI): 4.47 (3.99–5)], antiasthmatics [ROR (95% CI): 2.49 (2.14–2.89)], blood sugar control drugs [ROR (95% CI): 1.65 (1.38–1.97)], and digestive system drugs [ROR (95% CI): 1.59 (1.45–1.74)] exhibited progressively decreasing ROR values.</p>Conclusion<p>Many medications are associated with a high risk of angioedema. …”

Table3_Ureteropelvic junction obstruction in infants: Open or minimally invasive surgery? A systematic review and meta-analysis.doc by Valentina Cascini (14162511)

“…Minimally invasive surgery (MIS) procedures, including laparoscopic pyeloplasty (LP) and robot-assisted laparoscopic pyeloplasty (RALP), have been reported to achieve better outcomes (i.e., decreased morbidity, reduced postoperative pain, superior esthetic results, and shortened length of hospital stay, LOS), with a success rate similar to OP. …”

Supplementary file 1_Impacts of climate change on chronic respiratory health in Ethiopia: a systematic review and meta-analysis.docx by Zewudu Andualem (8602434)

“…</p>Results<p>A total of 21 studies with 10,785 participants were included, the pooled prevalence of chronic respiratory health was 39% (95% CI: 31–48%). …”

Table_2_Investigation of the causal association between Parkinson’s disease and autoimmune disorders: a bidirectional Mendelian randomization study.docx by Junyi Yang (602557)

“…</p>Results<p>Our MR findings suggested that genetically predicted higher liability to PD was causally associated with a decreased risk of irritable bowel syndrome (OR = 0.98; 95% CI: 0.96-0.99; P = 0.032). …”

Table_2_Dried fruit intake causally protects against low back pain: A Mendelian randomization study.DOCX by Jian Huang (7250)

Table_1_Dried fruit intake causally protects against low back pain: A Mendelian randomization study.DOCX by Jian Huang (7250)

Graphical output of results from movement counts data modeled as a function of treatment levels, week, and time discretized into 3-hour categories. by Kevin O. Ochwedo (11032248)

“…The IRR represents a multiplicative increase or decrease in the incidence rate based on a change in the predictor variable. …”

7SL-sRNA can be detected by directly from serum using a one-step RT-qPCR. by Stephen M. Chiweshe (6377585)

“…<p>A) Serum samples from a <i>T</i>. <i>brucei</i> infected cow (animal 6632, <a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0007189#pntd.0007189.g004" target="_blank">Fig 4</a>) were directly applied to a one-step RT-qPCR reaction, and the results compared to the two-step RT-qPCR reaction and parasitaemia scoring by microscopy. …”

Table 1_Efficacy and safety of levetiracetam in preventing postoperative seizures in adult patients with brain tumors: a meta-analysis.docx by Yongyi Zhang (1800337)

“…In addition, levetiracetam induced only minor adverse effects, with a lower occurrence rate of adverse reactions than phenytion sodium and valproate. …”

DataSheet_1_A Novel Tree Shrew Model of Chronic Experimental Autoimmune Uveitis and Its Disruptive Application.pdf by Kaijiao Hu (8978402)

“…RGS4 inhibition and dihydroartemisinin could significantly alleviate the retinal pathological injuries of IRBP_1197-1211-induced EAU by decreasing the expression of CD4 T-cells.</p>Conclusion<p>Our study provides a novel chronic EAU in tree shrews elicited by bovine R14 and tree shrew IRBP_1197-1211 characterized by retinal degeneration, retinal damage with subretinal Aβ deposits and microglia/macrophage infiltration, and T-cell response, probably by altering important pathways and genes related to bacterial invasion, inflammatory pain, microglial phagocytosis, and lipid and glucose metabolism. …”