5-HT2A and Foxo are required in R2/R4 neurons to mediate the effects of death perception on lifespan. by Christi M. Gendron (14200157)

“…(F) The amount of <i>Thor</i> mRNA, a Foxo target gene, was decreased in the heads of flies exposed to dead compared to unexposed flies (<i>n</i> = 16 each treatment). …”

DataSheet1_Anti-cancer activity of guggulsterone by modulating apoptotic markers: a systematic review and meta-analysis.docx by Meenakshi Gupta (3462941)

“…</p><p>Results: Based on this review, guggulsterone significantly affected pancreatic cancer (MiaPaCa-2, Panc-1, PC-Sw, CD18/HPAF, Capan1, PC-3), hepatocellular carcinoma (Hep3B, HepG2, PLC/PRF/5R), head and neck squamous cell carcinoma (SCC4, UM-22b, 1483), cholangiocarcinoma (HuCC-T1, RBE, Sk-ChA-1, Mz-ChA-1) and oesophageal adenocarcinoma (CP-18821, OE19), prostrate cancer (PC-3), colon cancer (HT-29), breast cancer (MCF7/DOX), gut derived adenocarcinoma (Bic-1), gastric cancer (SGC-7901), colorectal cancer (HCT116), bladder cancer (T24, TSGH8301), glioblastoma (A172, U87MG, T98G), histiocytic leukemia (U937), acute myeloid leukemia (HL60, U937) and non-small cell lung cancer (A549, H1975) by inducing apoptotic pathways, inhibiting cell proliferation, and regulating the expression of genes involved in apoptosis. …”

Image_6_Identification of cuproptosis-related subtypes, construction of a prognosis model, and tumor microenvironment landscape in gastric cancer.tif by Jinyan Wang (195882)

“…Nest, the Risk score system was constructed with moderate sensitivity and specificity. A high CRG Risk score, characterized by decreased microsatellite instability-high (MSI-H), tumor mutation burden (TMB) and cancer stem cell (CSC) index, and high stromal and immune score in TME, indicated poor survival. …”

Image_8_Identification of cuproptosis-related subtypes, construction of a prognosis model, and tumor microenvironment landscape in gastric cancer.tif by Jinyan Wang (195882)

“…Nest, the Risk score system was constructed with moderate sensitivity and specificity. A high CRG Risk score, characterized by decreased microsatellite instability-high (MSI-H), tumor mutation burden (TMB) and cancer stem cell (CSC) index, and high stromal and immune score in TME, indicated poor survival. …”

Table_1_Identification of cuproptosis-related subtypes, construction of a prognosis model, and tumor microenvironment landscape in gastric cancer.xlsx by Jinyan Wang (195882)

“…Nest, the Risk score system was constructed with moderate sensitivity and specificity. A high CRG Risk score, characterized by decreased microsatellite instability-high (MSI-H), tumor mutation burden (TMB) and cancer stem cell (CSC) index, and high stromal and immune score in TME, indicated poor survival. …”

Image_7_Identification of cuproptosis-related subtypes, construction of a prognosis model, and tumor microenvironment landscape in gastric cancer.tif by Jinyan Wang (195882)

“…Nest, the Risk score system was constructed with moderate sensitivity and specificity. A high CRG Risk score, characterized by decreased microsatellite instability-high (MSI-H), tumor mutation burden (TMB) and cancer stem cell (CSC) index, and high stromal and immune score in TME, indicated poor survival. …”

Image_1_Identification of cuproptosis-related subtypes, construction of a prognosis model, and tumor microenvironment landscape in gastric cancer.tif by Jinyan Wang (195882)

“…Nest, the Risk score system was constructed with moderate sensitivity and specificity. A high CRG Risk score, characterized by decreased microsatellite instability-high (MSI-H), tumor mutation burden (TMB) and cancer stem cell (CSC) index, and high stromal and immune score in TME, indicated poor survival. …”

Image_2_Identification of cuproptosis-related subtypes, construction of a prognosis model, and tumor microenvironment landscape in gastric cancer.tif by Jinyan Wang (195882)

“…Nest, the Risk score system was constructed with moderate sensitivity and specificity. A high CRG Risk score, characterized by decreased microsatellite instability-high (MSI-H), tumor mutation burden (TMB) and cancer stem cell (CSC) index, and high stromal and immune score in TME, indicated poor survival. …”

Recruitment of α5-GABA_ARs to PV-synapses contributes to wake-dependent enhancement of iLTP. by Kunwei Wu (725668)

“…(K) Representative PV-IPSC traces at indicated time points in (J). (L) L655,708 decreased the potentiation of PV-IPSC amplitude after NMDA application in wake and sleep-deprived mice (SD) but not sleep mice (<i>n</i> = 7–8, 2-way ANOVA, F (4, 38) = 4.234, <i>p</i> = 0.0062 with Sidak’s multiple comparison test, Sleep a versus Sleep b, <i>p</i> = 0.028; Sleep a versus Sleep c, <i>p</i> = 0.04; Wake a versus Wake b, <i>p</i> = 0.0014; Wake b versus Wake c, <i>p</i> = 0.023; Wake a versus Wake c, <i>p</i> = 0.0008; SD a versus SD b, <i>p</i> < 0.0001; SD b versus SD c, <i>p</i> = 0.0091; SD a versus SD c, <i>p</i> = 0.0002; Sleep b versus Wake b, <i>p</i> = 0.028; Sleep b versus SD b, <i>p</i> = 0.04). …”

Image_4_Identification of cuproptosis-related subtypes, construction of a prognosis model, and tumor microenvironment landscape in gastric cancer.tif by Jinyan Wang (195882)

“…Nest, the Risk score system was constructed with moderate sensitivity and specificity. A high CRG Risk score, characterized by decreased microsatellite instability-high (MSI-H), tumor mutation burden (TMB) and cancer stem cell (CSC) index, and high stromal and immune score in TME, indicated poor survival. …”

DataSheet2_Anti-cancer activity of guggulsterone by modulating apoptotic markers: a systematic review and meta-analysis.docx by Meenakshi Gupta (3462941)

“…</p><p>Results: Based on this review, guggulsterone significantly affected pancreatic cancer (MiaPaCa-2, Panc-1, PC-Sw, CD18/HPAF, Capan1, PC-3), hepatocellular carcinoma (Hep3B, HepG2, PLC/PRF/5R), head and neck squamous cell carcinoma (SCC4, UM-22b, 1483), cholangiocarcinoma (HuCC-T1, RBE, Sk-ChA-1, Mz-ChA-1) and oesophageal adenocarcinoma (CP-18821, OE19), prostrate cancer (PC-3), colon cancer (HT-29), breast cancer (MCF7/DOX), gut derived adenocarcinoma (Bic-1), gastric cancer (SGC-7901), colorectal cancer (HCT116), bladder cancer (T24, TSGH8301), glioblastoma (A172, U87MG, T98G), histiocytic leukemia (U937), acute myeloid leukemia (HL60, U937) and non-small cell lung cancer (A549, H1975) by inducing apoptotic pathways, inhibiting cell proliferation, and regulating the expression of genes involved in apoptosis. …”

Image_5_Identification of cuproptosis-related subtypes, construction of a prognosis model, and tumor microenvironment landscape in gastric cancer.tif by Jinyan Wang (195882)

“…Nest, the Risk score system was constructed with moderate sensitivity and specificity. A high CRG Risk score, characterized by decreased microsatellite instability-high (MSI-H), tumor mutation burden (TMB) and cancer stem cell (CSC) index, and high stromal and immune score in TME, indicated poor survival. …”

Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice by Vladimir Ilievski (789625)

“…Further, studies using animal model of periodontitis and human post-mortem brain tissues from subjects with AD strongly suggest that a gram-negative periodontal pathogen, <i>Porphyromonas gingivalis</i> (Pg) and/or its product gingipain is/are translocated to the brain. …”

Formation of Ammonia in the Reactions of a Tungsten Dinitrogen with Ruthenium Dihydrogen Complexes under Mild Reaction Conditions¹ by Yoshiaki Nishibayashi (1606090)

“…If the p<i>K</i>_a value of a Ru(η²-H₂) complex was increased up to about 10, the yield of NH₃ was remarkably decreased. …”

Glial 5-HT_2a receptors are necessary and rate limiting for experience-dependent synaptic glomeruli pruning. by Vanessa Kay Miller (19775496)

“…The Or42a OSN innervation volume with glial <i>5-HT</i>_<i>2A</i><i>R</i> OE is very significantly decreased in comparison to the control EB condition (<i>p</i> = 4.64 × 10⁻¹⁰). …”

Health in times of uncertainty in the eastern Mediterranean region, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013 by Mokdad, Ali H

“…Since our Global Burden of Disease Study 2010 (GBD 2010), the region has faced unrest as a result of revolutions, wars, and the so-called Arab uprisings. …”
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Health in times of uncertainty in the eastern Mediterranean region, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013 by Mokdad, Ali H

“…Since our Global Burden of Disease Study 2010 (GBD 2010), the region has faced unrest as a result of revolutions, wars, and the so-called Arab uprisings. …”
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A perceived warmer temperature alters the desaturation of membrane phospholipids in <i>hsf-1</i> worms, providing an adaptive advantage. by Laetitia Chauve (8600553)

“…<p><b>(A–C)</b><i>hsf-1</i>^<i>neuro</i> is beneficial for life span at 25°C but not at 15°C. …”

Basic information and patient characteristics according to the report. by Xiaoling Zhong (181270)

Multiple bacterial subpopulations are present within splenic microcolonies. by Justin Greene (306625)