Developing a Hetero-Trinuclear Erbium(III)–Copper(II) Complex Based on Apoferritin: Targeted Photoacoustic Imaging and Multimodality Therapy of Tumor by Minghui Zhu (1506775)

“…For the integration of targeted diagnosis and treatment of tumor, we innovatively designed and synthesized a single-molecule hetero-multinuclear Er(III)–Cu(II) complex (<b>ErCu</b>_<b>2</b>) and then constructed an <b>ErCu</b>_<b>2</b>@apoferritin (AFt) nanoparticle (NP) delivery system. …”

Design, Synthesis, and Biological Evaluation of New Peripheral 5HT_2A Antagonists for Nonalcoholic Fatty Liver Disease by Minhee Kim (1592440)

“…The in vitro and in vivo blood–brain barrier permeability study proved that <b>14a</b> acts peripherally. Compound <b>14a</b> decreased the liver weight and hepatic lipid accumulation in high-fat-diet-induced obesity mice. …”

DataSheet_1_Integrative network analysis revealed the molecular function of folic acid on immunological enhancement in a sheep model.docx by Bing Wang (126120)

“…Meanwhile, folic acid increased the abundances of S100A12 and IRF6 but decreased TMEM25 in the liver. …”

Table_1_A Genome-Wide Screen Identifies Factors Involved in S. aureus-Induced Human Neutrophil Cell Death and Pathogenesis.docx by Dingyi Yang (6279989)

“…The aim of this study was to better understand the mechanisms underpinning S. aureus-induced neutrophil lysis, and how this contributes to pathogenesis in a whole organism model of infection. To do this we screened the genome-wide Nebraska Transposon Mutant Library (NTML) in the community acquired methicillin resistant S. aureus strain, USA300, for decreased ability to induce neutrophil cell lysis. …”

Table_6_Evidence of a Causal Relationship Between Vitamin D Status and Risk of Psoriasis From the UK Biobank Study.XLSX by Yan Zhang (8098)

“…</p>Results<p>During a median follow-up of 10.99 years, we identified 2,856 participants with incident psoriasis. …”

Image_2_A Novel Calcium-Activated Potassium Channel Controls Membrane Potential and Intracellular pH in Trypanosoma cruzi.TIF by Patricia Barrera (8300316)

“…As predicted, a single point mutation in the selectivity filter (Y313A) completely abolished the activity of the channels, confirming its potassium selective nature. …”

Image1_Vitamin D and Lipid Profiles in Postmenopausal Women: A Meta-Analysis and Systematic Review of Randomized Controlled Trials.tif by Weiting Liu (8377335)

Data_Sheet_1_Assessing the Temporal Organization of Walking Variability: A Systematic Review and Consensus Guidelines on Detrended Fluctuation Analysis.PDF by Deepak K. Ravi (6786095)

“…Aging and PD exhibited a negative effect size (i.e., led to decreased long-range correlations) of −0.20 and −0.53, respectively. …”

Data_Sheet_1_As a Staple Food Substitute, Oat and Buckwheat Compound Has Health-Promoting Effects for Diabetic Rats.docx by Siqi Liu (6569)

“…What's more, ileal epithelial tight junction proteins and gut microbiota were analyzed. Significant decreases in fasting blood glucose (FBG), glucose tolerance, serum insulin, and insulin resistance were observed in rats intervened with OBC, and these rats also showed a higher level of superoxide dismutase (SOD) together with improved lipid metabolism, attenuated inflammation, and liver and kidney injuries. …”

DataSheet1_Political Sensitivity and Carbon Emissions: Evidence From a Quasi-Natural Experiment of Leadership Change in China.xlsx by Zhi Su (1431691)

“…<p>While there is extensive literature assessing the impact of command-and-control and market-incentive environmental regulation on carbon emissions, it overlooks the fact that command-and-control environmental regulation and market-incentive environmental regulation are the embodiment of the national concept of green development. When a national leader with a green development philosophy is in power, local governments (due to the competition among them) adjust the economic development strategies and targets in their jurisdictions according to the leaders’ philosophy, resulting in differences in urban carbon emissions. …”

Data_Sheet_1_Circulating Tumor Biomarkers in Meningiomas Reveal a Signature of Equilibrium Between Tumor Growth and Immune Modulation.PDF by Erdogan Pekcan Erkan (7482248)

“…Recurrence occurs in higher grade meningiomas and a small subset of Grade I meningiomas with benign histology. …”

Data_Sheet_1_A coordinate-based meta-analysis of acupuncture for chronic pain: Evidence from fMRI studies.docx by Zheng Yu (484983)

“…</p>Conclusion<p>This ALE meta-analysis pointed out that acupuncture could modulate the default mode network, the frontoparietal network to treat CP. This provided a systematic summary of the neuroimage biomarker of acupuncture for the treatment of CP.…”

Table_9_Transcriptome Profiling Reveals a Petunia Transcription Factor, PhCOL4, Contributing to Antiviral RNA Silencing.XLSX by Yingru Xu (11206420)

“…<p>RNA silencing is a common antiviral mechanism in eukaryotic organisms. …”

Data_Sheet_1_Disability health in medical education: development, implementation, and evaluation of a pilot curriculum at Stanford School of Medicine.DOCX by Richard W. Sapp (19535422)

“…</p>Objective<p>Two educational interventions were structured: (1) a brief 2-h intervention in the mandatory curriculum and (2) a 9-week elective course which included interactions with individuals with disabilities through workshops and partner programs. …”

Alzheimer's Disease-Linked Mutations in <em>Presenilin-1</em> Result in a Drastic Loss of Activity in Purified γ-Secretase Complexes by Matthias Cacquevel (170529)

“…Moreover, controversy exists as to how PS1 mutations exert their effects in different experimental systems, by either increasing Aβ1–42 production, decreasing Aβ1–40 production, or both. …”

Image_1_Effects of Non-insulin Anti-hyperglycemic Agents on Gut Microbiota: A Systematic Review on Human and Animal Studies.JPEG by Thao T. B. Cao (9408581)

“…<p>Background: As growing evidence links gut microbiota with the therapeutic efficacy and side effects of anti-hyperglycemic drugs, this article aims to provide a systematic review of the reciprocal interactions between anti-hyperglycemic drugs and gut microbiota taxa, which underlie the effect of the gut microbiome on diabetic control via bug-host interactions.…”

Reproducibility of Search Strategies Is Poor in Systematic Reviews Published in High-Impact Pediatrics, Cardiology and Surgery Journals: A Cross-Sectional Study by Jonathan B. Koffel (734579)

“…In addition, authors often report a single strategy as covering all databases searched, further decreasing reproducibility. …”

DataSheet_1_12/15-lipoxygenase activity promotes efficient inflammation resolution in a murine model of Lyme arthritis.pdf by Christa D. Jackson (15308896)

“…Therapeutic treatment of B. burgdorferi-infected C3H mice with lipoxin A4 (LXA₄) near the peak of disease resulted in significantly decreased ankle swelling and a switch of joint macrophages to a resolving phenotype but did not directly impact arthritis severity. …”

Datasheet1_Impact of amlodipine on clinical outcomes for heart failure in patients with dilated cardiomyopathy: a Korean nationwide cohort study.pdf by SungA Bae (9105476)

“…In a subgroup analysis, amlodipine had a significant impact on decreasing all-cause mortality in older adults, those with a higher systolic blood pressure, and those with a lower Charlson Comorbidity Index.…”

Image1_Child-Onset Cerebellar Ataxia Caused by Two Compound Heterozygous Variants in ADPRS Gene: A Case Report.TIF by Jiehui Ma (10792134)

“…</p><p>Case Presentation: After a respiratory tract infection, a 30-month-old male patient presented with unsteady gait that rendered walking impossible without external help. …”