Image3_Olaparib, a PARP-1 inhibitor, protects retinal cells from ocular hypertension-associated oxidative damage.jpg by Yuting Yang (1334322)

“…Additionally, some indicators of mitochondrial performance, such as reactive oxygen species accumulation, mitochondrial Ca²⁺ influx, and mitochondrial membrane potential collapse, decreased after olaparib treatment. Olaparib attenuated the hypoxia-induced upregulation of NLRP3 protein levels as well as the phosphorylation of ERK1/2 and histone H2A.X. …”

Image5_Child-Onset Cerebellar Ataxia Caused by Two Compound Heterozygous Variants in ADPRS Gene: A Case Report.TIF by Jiehui Ma (10792134)

“…</p><p>Case Presentation: After a respiratory tract infection, a 30-month-old male patient presented with unsteady gait that rendered walking impossible without external help. …”

Table 1_The role of gut microbiota in modulating immune responses in chronic liver disease: a systematic review and meta-analysis.docx by Eyad Gadour (21375983)

“…Introduction<p>The gut microbiota plays a crucial role in regulating immune responses and maintaining a balance within the gut-liver axis. …”

Image_7_Long-Term Overconsumption of Fat and Sugar Causes a Partially Reversible Pre-inflammatory Bowel Disease State.JPEG by Djésia Arnone (11722319)

“…In healthy mice, a high-fat high-sucrose diet induces a pre-IBD state characterized by gut microbiota dysbiosis with a total depletion of bacteria belonging to Barnesiella that is associated with subclinical endoscopic lesions. …”

Table 1_The efficacy and safety of danuglipron and orforglipron in patients with type 2 diabetes and obesity: a systematic review and meta-analysis.docx by Jingjing Zhou (179820)

“…Meta-analysis results demonstrated that danuglipron significantly decreased HbA1c (mean difference [MD]: −0.90; 95% CI: −1.06, −0.74), FPG (MD: −24.66; 95% CI: −30.45, −18.86) and weight (MD: −2.17; 95% CI: −3.10, −1.23) and improved FPI (MD: 2.94; 95% CI: 1.50, 4.38). …”

Image_5_IL-1β Blockade Attenuates Thrombosis in a Neutrophil Extracellular Trap-Dependent Breast Cancer Model.tif by Tainá Gomes (628536)

“…On the other hand, mice bearing non-metastatic 67NR tumors showed no elevation in neutrophil counts and displayed low expression levels of G-CSF and IL-1β in their tumors. 4T1 tumor-bearing mice but not 67NR tumor-bearing mice exhibited a NET-dependent prothrombotic state. Pharmacological blockade of IL-1 receptor (IL-1R) decreased the primary growth of 4T1 tumors and reduced the systemic levels of myeloperoxidase, cell-free DNA (cfDNA) and G-CSF, without interfering with the neutrophil counts. …”

IL-22-Producing RORγt-Dependent Innate Lymphoid Cells Play a Novel Protective Role in Murine Acute Hepatitis by Atsuhiro Matsumoto (405471)

“…Collectively, hepatic RORγt-dependent ILCs play a part of protective roles in hepatic immune response in mice.…”

Image_4_Effects of Non-insulin Anti-hyperglycemic Agents on Gut Microbiota: A Systematic Review on Human and Animal Studies.JPEG by Thao T. B. Cao (9408581)

“…<p>Background: As growing evidence links gut microbiota with the therapeutic efficacy and side effects of anti-hyperglycemic drugs, this article aims to provide a systematic review of the reciprocal interactions between anti-hyperglycemic drugs and gut microbiota taxa, which underlie the effect of the gut microbiome on diabetic control via bug-host interactions.…”

Supplementary Material for: Markers Involved in Innate Immunity and Neutrophil Activation are Elevated during Acute Human Anaphylaxis: Validation of a Microarray Study by Francis A. (5723444)

“…<b><i>Background:</i></b> We have previously identified the upregulation of the innate immune response, neutrophil activation, and apoptosis during anaphylaxis using a microarray approach. This study aimed to validate the differential gene expression and investigate protein concentrations of “hub genes” and upstream regulators during anaphylaxis. …”

Image_2_Spatial Changes in the Atrial Fibrillation Wave-Dynamics After Using Antiarrhythmic Drugs: A Computational Modeling Study.TIF by Inseok Hwang (2395927)

“…<p>Background: We previously reported that a computational modeling-guided antiarrhythmic drug (AAD) test was feasible for evaluating multiple AADs in patients with atrial fibrillation (AF). …”

Table_1_Number and nature of psychiatric emergency department visits in a tertiary hospital before, during, and after coronavirus pandemic.docx by Claudia Aymerich (11334705)

“…In contrast, visits for schizophrenia and other psychotic disorders (Z=4.85; p<0.001), as well as unspecified behavioral alterations (Z=2.51; p=0.012), significantly decreased.</p>Conclusion<p>The COVID-19 pandemic and its aftermath have altered the patterns of urgent psychiatric care, characterized by a sharp increase of average monthly number of consultations and a shift in their nature. …”

Table1_Randomized control trial of a childhood obesity prevention family-based program: “Abriendo Caminos” and effects on BMI.pdf by Margarita Teran-Garcia (16035638)

“…This article evaluates the effect of a family-based, childhood obesity primary prevention intervention in a community setting.…”

The ubiquitin-conjugating enzyme CDC34 is essential for cytokinesis in contrast to putative subunits of a SCF complex in <i>Trypanosoma brucei</i> by Federico Rojas (480253)

“…<div><p>The ubiquitin-proteasome system is a post-translational regulatory pathway for controlling protein stability and activity that underlies many fundamental cellular processes, including cell cycle progression. …”

Table_3_Dietary inflammatory index and the risks of non-alcoholic fatty liver disease: a systematic review and meta-analysis.DOCX by Xingfen Zhang (19226734)

“…</p>Conclusion<p>The results suggest that high DII is associated with an increased risk of NAFLD, and conversely, low DII is associated with a decreased risk of NAFLD.</p>Systematic Review Registration<p>The study complies with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and is registered on PROSPERO (CRD42023455013).…”

Image_2_A Novel Calcium-Activated Potassium Channel Controls Membrane Potential and Intracellular pH in Trypanosoma cruzi.TIF by Patricia Barrera (8300316)

“…As predicted, a single point mutation in the selectivity filter (Y313A) completely abolished the activity of the channels, confirming its potassium selective nature. …”

Functional Analysis of a Breast Cancer-Associated FGFR2 Single Nucleotide Polymorphism Using Zinc Finger Mediated Genome Editing by Luisa J. Robbez-Masson (483097)

“…The potential effect of these SNPs, in intron two, was postulated to be due to the differential binding of cis-regulatory elements, such as transcription factors, since all the SNPs in linkage disequilibrium were located in a regulatory DNA region. A Runx2 binding site was reported to be functional only in the minor, disease associated allele of rs2981578, resulting in increased expression of FGFR2 in cancers from patients homozygous for that allele. …”

Image2_Vitamin D and Lipid Profiles in Postmenopausal Women: A Meta-Analysis and Systematic Review of Randomized Controlled Trials.tif by Weiting Liu (8377335)

Table_3_Transcriptome Profiling Reveals a Petunia Transcription Factor, PhCOL4, Contributing to Antiviral RNA Silencing.XLSX by Yingru Xu (11206420)

“…<p>RNA silencing is a common antiviral mechanism in eukaryotic organisms. …”

Table1_Effects of physical activity on the severity of illness and mortality in COVID-19 patients: A systematic review and meta-analysis.docx by Nuttawut Sittichai (14072646)

“…Subgroup analysis showed that PA for ≥150 min/wk at a moderate intensity or ≥75 min/wk at a vigorous intensity reduced the risks of severity and mortality. …”

Image4_New insight into the analgesic recipe: A cohort study based on smart patient-controlled analgesia pumps records.pdf by Yiyan Song (4738617)

“…In China, the most often used opioid is sufentanil, for which repeated doses are a concern, and empirical flurbiprofen axetil (FBP) as an adjuvant. …”