Image_1_A Novel Calcium-Activated Potassium Channel Controls Membrane Potential and Intracellular pH in Trypanosoma cruzi.TIF by Patricia Barrera (8300316)

“…As predicted, a single point mutation in the selectivity filter (Y313A) completely abolished the activity of the channels, confirming its potassium selective nature. …”

Image_2_The Sole DNA Ligase in Entamoeba histolytica Is a High-Fidelity DNA Ligase Involved in DNA Damage Repair.JPEG by Elisa Azuara-Liceaga (244026)

“…We found that EhDNAligI is a high-fidelity DNA ligase on canonical substrates and is able to discriminate erroneous base-pairing opposite DNA lesions. …”

Image_2_IL-1β Blockade Attenuates Thrombosis in a Neutrophil Extracellular Trap-Dependent Breast Cancer Model.tif by Tainá Gomes (628536)

“…On the other hand, mice bearing non-metastatic 67NR tumors showed no elevation in neutrophil counts and displayed low expression levels of G-CSF and IL-1β in their tumors. 4T1 tumor-bearing mice but not 67NR tumor-bearing mice exhibited a NET-dependent prothrombotic state. Pharmacological blockade of IL-1 receptor (IL-1R) decreased the primary growth of 4T1 tumors and reduced the systemic levels of myeloperoxidase, cell-free DNA (cfDNA) and G-CSF, without interfering with the neutrophil counts. …”

β-blockers after acute myocardial infarction in patients with chronic obstructive pulmonary disease: A nationwide population-based observational study by Tse-Hsuan Su (6425153)

“…</p><p>Methods and results</p><p>We conducted a nationwide population-based cohort study using data retrieved from Taiwan National Health Insurance Research Database. …”

Image_2_A Genome-Wide Screen Identifies Factors Involved in S. aureus-Induced Human Neutrophil Cell Death and Pathogenesis.JPEG by Dingyi Yang (6279989)

“…The aim of this study was to better understand the mechanisms underpinning S. aureus-induced neutrophil lysis, and how this contributes to pathogenesis in a whole organism model of infection. To do this we screened the genome-wide Nebraska Transposon Mutant Library (NTML) in the community acquired methicillin resistant S. aureus strain, USA300, for decreased ability to induce neutrophil cell lysis. …”

DataSheet1_Causal relationship between human blood metabolites and risk of ischemic stroke: a Mendelian randomization study.ZIP by Menghao He (17812799)

“…<p>Background: Ischemic stroke (IS) is a major cause of death and disability worldwide. …”

Table_5_Transcriptome Profiling Reveals a Petunia Transcription Factor, PhCOL4, Contributing to Antiviral RNA Silencing.XLSX by Yingru Xu (11206420)

“…<p>RNA silencing is a common antiviral mechanism in eukaryotic organisms. …”

Image3_New insight into the analgesic recipe: A cohort study based on smart patient-controlled analgesia pumps records.JPEG by Yiyan Song (4738617)

“…In China, the most often used opioid is sufentanil, for which repeated doses are a concern, and empirical flurbiprofen axetil (FBP) as an adjuvant. …”

Image1_Safety and efficacy of NOAC vs. VKA in patients treated by PCI: a retrospective study of the FRANCE PCI registry.tiff by Eric Durand (197728)

“…Introduction<p>Dual antithrombotic therapy (DAT) combining oral anticoagulation (OAC), preferentially Non-vitamin K antagonist OAC (NOAC) and single antiplatelet therapy (SAPT) for a period of 6–12 months is recommended after percutaneous coronary intervention (PCI) in patients with an indication for OAC.…”

Soil plant available silicon from a bamboo forest on karst mountain in southwest China differs between wet and dry seasons by Bin Xu (10691)

“…The citric-Si content of soils and drip water Si was in the range of 24.6–164 mg·kg⁻¹ and 3.63–13.6 mg·kg⁻¹, respectively, and decreased in the following order: A and AB horizon, O horizon, and drip water. …”

Data_Sheet_1_Hypoglycemia is associated with a higher risk of mortality and arrhythmias in ST-elevation myocardial infarction, irrespective of diabetes.docx by Basel Humos (13928754)

“…</p>Conclusion<p>Hypoglycemia is a rare event in patients hospitalized with STEMI. …”

Table_1_Mitofusin2, as a Protective Target in the Liver, Controls the Balance of Apoptosis and Autophagy in Acute-on-Chronic Liver Failure.docx by Ran Xue (748944)

“…Mfn2 will provide a promising therapeutic target for patients with ACLF.…”

Image7_Child-Onset Cerebellar Ataxia Caused by Two Compound Heterozygous Variants in ADPRS Gene: A Case Report.TIF by Jiehui Ma (10792134)

“…</p><p>Case Presentation: After a respiratory tract infection, a 30-month-old male patient presented with unsteady gait that rendered walking impossible without external help. …”

DataSheet1_Exploring the Retinal Binding Cavity of Archaerhodopsin-3 by Replacing the Retinal Chromophore With a Dimethyl Phenylated Derivative.docx by Taichi Tsuneishi (11855783)

“…Noteworthy, AO3-DMP had several significant changes in its molecular properties compared with AO3-A1 as follows; 1) spectroscopic measurements revealed that the absorption maximum was shifted from 556 to 508 nm and QM/MM calculations showed that the blue-shift was due to the significant increase in the HOMO-LUMO energy gap of the chromophore with the contribution of some residues around the chromophore, 2) time-resolved spectroscopic measurements revealed the photocycling rate was significantly decreased, and 3) kinetical spectroscopic measurements revealed the sensitivity of the chromophore binding Schiff base to attack by hydroxylamine was significantly increased. …”

Data_Sheet_1_Adult-onset neuronal intranuclear inclusion disease related retinal degeneration: a Chinese case series.DOCX by Chaoyi Feng (17787314)

“…</p>Results<p>Nine patients (18 eyes) were evaluated, with a median age of 62 years (55–68) and only one man was included in our study. …”

DataSheet1_Antiviral Efficacy and Safety of Molnupiravir Against Omicron Variant Infection: A Randomized Controlled Clinical Trial.docx by Rongrong Zou (6088067)

“…<p>Background: The rapid worldwide spread of the Omicron variant of SARS-CoV-2 has unleashed a new wave of COVID-19 outbreaks. The efficacy of molnupiravir, an approved drug, is still unknown in patients infected with the Omicron variant.…”

Supplementary Material for: Effect of Bronchodilators on Forced Expiratory Volume in 1 s in Preterm-Born Participants Aged 5 and Over: A Systematic Review by Kotecha S.J. (4150984)

“…<b><i>Design:</i></b> Studies reporting a change in þV₁ in response to bronchodilator treatment in preterm-born participants at ≥5 years of age, with or without a term-born control group, were identified. …”

Image 1_Ticagrelor vs. clopidogrel in dual antiplatelet therapy after coronary artery bypass surgery: a meta-analysis.tif by Liyuan Wang (795570)

“…</p>Results<p>4 randomized controlled trials and 3 observational studies (n = 2,424) were eligible for final analysis. A + T was associated with a decreased risk of all-cause mortality (OR = 0.47, 95% CI 0.31–0.70, p < 0.001, p heterogeneity = 0.80, I² = 0%) and cardiovascular mortality (OR = 0.50, 95% CI 0.31–0.82, p = 0.006, p heterogeneity = 0.71, I² = 0%), compared with A + C group. …”

Time’s Up. Descriptive Epidemiology of Multi-Morbidity and Time Spent on Health Related Activity by Older Australians: A Time Use Survey by Tanisha Jowsey (396920)

“…This article presents findings from an Australian study concerning the time spent on health related activity by older adults (aged 50 years and over), most of whom had multiple chronic conditions. A recall questionnaire was developed, piloted, and adjusted. …”

Image_3_IL-1β Blockade Attenuates Thrombosis in a Neutrophil Extracellular Trap-Dependent Breast Cancer Model.tif by Tainá Gomes (628536)

“…On the other hand, mice bearing non-metastatic 67NR tumors showed no elevation in neutrophil counts and displayed low expression levels of G-CSF and IL-1β in their tumors. 4T1 tumor-bearing mice but not 67NR tumor-bearing mice exhibited a NET-dependent prothrombotic state. Pharmacological blockade of IL-1 receptor (IL-1R) decreased the primary growth of 4T1 tumors and reduced the systemic levels of myeloperoxidase, cell-free DNA (cfDNA) and G-CSF, without interfering with the neutrophil counts. …”