Data_Sheet_1_Global trends in COVID-19 incidence and case fatality rates (2019–2023): a retrospective analysis.PDF by Juan Du (118107)

“…Infection rates in Asia showed a steady increase in contrast to other continents which observed initial rises followed by decreases. …”

Image_1_Differential Modulation of Mouse Heart Gene Expression by Infection With Two Trypanosoma cruzi Strains: A Transcriptome Analysis.TIF by Tiago Bruno Rezende de Castro (9335921)

“…<p>The protozoan Trypanosoma cruzi (T. cruzi) is a well-adapted parasite to mammalian hosts and the pathogen of Chagas disease in humans. …”

DataSheet_1_The Prognostic Significance of PD1 and PDL1 Gene Expression in Lung Cancer: A Meta-Analysis.pdf by Chih-Hao Chang (1483537)

“…</p>Results<p>The mean expression levels of PDL1 in adenocarcinoma (AD) and squamous cell carcinoma (SC) were significantly higher in patients who died than in patients who did not. There was a trend toward incremental increases in PD1 and PDL1 expression significantly decreasing the risk of relapse and death among AD patients (HR = 0.69; 95% CI = 0.53 ~ 0.91; HR = 0.68; 95% CI = 0.54 ~ 0.84, respectively) and SC patients (HR = 0.53; 95% CI = 0.32 ~ 0.89; HR = 0.78; 95% CI = 0.57 ~ 1.00 respectively), as early-stage patients in this study were more likely to have high expression of both PD1 and PDL1 than late-stage patients (P-trend < 0.05). …”

Table_3_Comparison of the fecal microbiota of adult healthy dogs fed a plant-based (vegan) or an animal-based diet.docx by Brooklynn D. Liversidge (17614638)

“…This study aimed to examine the canine fecal microbiota in response to a vegan diet compared to an animal-based diet.</p>Methods<p>Sixty-one client-owned healthy adult dogs completed a randomized, double-blinded longitudinal study. …”

Video_1_Relationship between engagement with the impossible task, cognitive testing, and cognitive questionnaires in a population of aging dogs.mp4 by Michael Z. Khan (14325651)

“…Introduction<p>The aim of this study was to evaluate the engagement of aging dogs with a cognitively challenging and potentially frustrating task (the impossible task). …”

Table_3_The plasma lipids with different fatty acid chains are associated with the risk of hemorrhagic stroke: a Mendelian randomization study.xlsx by Xingkai Zhang (18065716)

“…Notably, lipids containing arachidonic acid chains (C20:4) such as PC 18:1;0_20:4;0 consistently showed a decreased risk of both intracerebral hemorrhage [p < 0.001; OR(95% CI) = 0.892(0.835–0.954)] and subarachnoid hemorrhage [p = 0.002; OR(95% CI) = 0.794(0.689–0.916)]. …”

Image1_A comprehensive analysis of metabolomics and transcriptomics to reveal major metabolic pathways and potential biomarkers of human preeclampsia placenta.JPEG by Yan Feng (128912)

“…</p><p>Conclusion: Our findings provide a profile of the dysregulated steroid hormone biosynthesis in PE placenta, we observed a dysregulated cortisol-to-cortisone ratio, testosterone accumulation, decreased testosterone downstream metabolites, impaired production of estrone and estriol, and aberrant hydroxylation and methylation of estradiol. …”

Table1_Causal relationship between inflammatory proteins and glioblastoma: a two-sample bi‑directional mendelian randomization study.DOCX by Xiang Lin (525346)

“…</p><p>Results: Our findings from employing the inverse variance weighted method in our forward MR analysis provide robust evidence supporting a potential association between glioblastoma and elevated levels of Cystatin D, as well as decreased levels of fibroblast growth factor 21 (FGF21) in the circulation. …”

Table_3_Altered Lipid Profile Is a Risk Factor for the Poor Progression of COVID-19: From Two Retrospective Cohorts.doc by Hui Jin (38113)

“…</p>Conclusions<p>The baseline dyslipidemia should be considered as a risk factor for poor prognosis of COVID-19. However, lipid levels may be altered during the COVID-19 course, since lipidology may be distinctly affected by both inflammation and organic damage for SARS-CoV-2.…”

Table 2_Causality of genetically determined serum metabolites on lower back pain or/and sciatica: a comprehensive Mendelian randomized study.docx by Yi-Ming Ren (555968)

“…This study aimed to conduct a two sample bidirectional Mendelian randomization (MR) analysis to explore the causal link between 486 serum metabolites and lower back pain or/and sciatica.…”

Table_2_Anti-TNF Drugs for Chronic Uveitis in Adults—A Systematic Review and Meta-Analysis of Randomized Controlled Trials.pdf by Inês Leal (5996858)

“…Meta-analysis of efficacy analysis was not performed due to significant clinical heterogeneity between studies' population and interventions.</p><p>Results: A total of 1,157 references were considered and 3 studies were included. …”

Switching the Mode of Drug Release from a Reaction-Coupled Low-Molecular-Weight Gelator System by Altering Its Reaction Pathway by Willem E. M. Noteborn (5485346)

“…Fitting of the drug release profiles with the Korsmeyer–Peppas model corroborates a switch in the mode of release consistent with the reaction pathway taken: increased covalent ligation drives a transition from a Fickian to a semi-Fickian mode in the second stage of release with a decreased rate. …”

DataSheet1_Effect of traditional Chinese medicine on postoperative depression of breast cancer: a systematic review and meta-analysis.doc by Yan Wang (15435)

“…Clinical practice and many studies have shown that traditional Chinese medicine (TCM) has a good effect on postoperative depression of BC. …”

Table_3_Tumor cuproptosis and immune infiltration improve survival of patients with hepatocellular carcinoma with a high expression of ferredoxin 1.xlsx by Yingyao Quan (7105034)

“…Meanwhile, we found that a high expression of FDX1 decreased cell viability in HCC samples. …”

Characterization of <i>Triticum aestivum</i> Abscisic Acid Receptors and a Possible Role for These in Mediating Fusairum Head Blight Susceptibility in Wheat by Cameron S. Gordon (3226968)

“…Mutagenic analysis showed Ta_PYL2DS_FL amino acid D180 as being a critical contributor to this selectivity. Subsequently, a virus induced gene silencing (VIGS) approach was used to knockdown wheat Ta_PYL4AS_A (and similar) <i>in planta</i>, yielding plants with increased early stage resistance to FHB progression and decreased mycotoxin accumulation. …”

Table_1_Quantitative Proteomics Reveals That a Prognostic Signature of the Endometrium of the Polycystic Ovary Syndrome Women Based on Ferroptosis Proteins.docx by Jian Zhang (1682)

“…Compared with clinical data, ROC curve analysis indicated the FerSig proteins as a potential diagnostic and prognostic factor in PCOS patients. …”

Image_1_A Single Low Dose of Dexmedetomidine Efficiently Attenuates Esketamine-Induced Overactive Behaviors and Neuronal Hyperactivities in Mice.tif by Qinjun Chu (4051534)

“…However, Dex dose-dependently increased the recovery time from anesthesia. It demonstrated that a small dose of Dex 0.25 mg/kg could be sufficient to attenuate Esk-induced psychotomimetic side effects without extension of recovery time in Kunming mice.…”

Table_2_Oral swabs as a proxy for direct ruminal microbiome sampling in Holstein dairy cows is correlated with sample color.XLSX by Joseph H. Skarlupka (5830637)

“…To correlate swab color to the microbiota we developed and utilized a novel imaging approach to colorimetrically quantify each swab from a range of light to dark. …”

Image_2_Urban Diets Linked to Gut Microbiome and Metabolome Alterations in Children: A Comparative Cross-Sectional Study in Thailand.TIF by Juma Kisuse (5437766)

Data_Sheet_1_The Microbiome Stress Project: Toward a Global Meta-Analysis of Environmental Stressors and Their Effects on Microbial Communities.docx by Jennifer D. Rocca (2403376)

“…Overall, we found that stressor exposure significantly decreases microbiome alpha diversity and increases beta diversity (community dispersion) across a range of environments and stressor types. …”