Table 1_Therapeutic potential of Triptolide in inhibiting breast cancer-induced bone destruction – PTHrP as a therapeutic target.docx by Wu Di (11561998)

“…Our findings suggest that TP inhibits NF-κB and ERK signaling pathways, reduces breast cancer-induced osteoclastogenesis, and decreases NFATc1, CTSK, and RANKL expression. Molecular assays revealed a direct binding affinity between TP and PTHrP, suggesting TP interferes with PTHrP‐mediated signaling that promotes osteoclast activity.…”

Combining QTL mapping with transcriptome and metabolome profiling reveals a possible role for ABA signaling in resistance against the cabbage whitefly in cabbage by Colette Broekgaarden (77969)

“…However, nearly all insecticides pose a threat to the environment and alternative control methods, such as breeding of crop varieties that are inherently insect-resistant, are needed. …”

Table_5_Ephrin-B1 Is a Novel Biomarker of Bladder Cancer Aggressiveness. Studies in Murine Models and in Human Samples.DOC by María Victoria Mencucci (8628969)

“…This study thoroughly analyzed E-cadherin and associated changes in BC, and reports Ephrin-B1 as a new marker of tumor aggressiveness.</p>…”

Image_3_A New Approach for Loading Anticancer Drugs Into Mesenchymal Stem Cell-Derived Exosome Mimetics for Cancer Therapy.TIF by Senthilkumar Kalimuthu (4262077)

“…MSCs (4 × 10⁶ cells/mL) were mixed with or without PTX at different concentrations in phosphate-buffered saline (PBS) and serially extruded through 10-, 5-, and 1-μm polycarbonate membrane filters using a mini-extruder. MSCs were centrifuged to remove debris and the supernatant was filtered through a 0.22-μm filter, followed by ultracentrifugation to isolate EMs and drug-loaded EMs. …”

Image2_Identification and Validation of a Prognostic Risk-Scoring Model Based on Ferroptosis-Associated Cluster in Acute Myeloid Leukemia.TIFF by Jinghua Wang (101820)

“…A nomogram containing clinical factors and prognostic risk-scoring model was constructed to better estimate individual survival. …”

Datasheet2_The causal relationship between human blood metabolites and risk of peripheral artery disease: a Mendelian randomization study.csv by Zhiyong Dong (1930624)

“…Background<p>Peripheral Artery Disease (PAD) is a common vascular disorder typically caused by atherosclerosis, leading to impaired blood supply to the lower extremities, resulting in pain, necrosis, and even amputation. …”

Table 1_The burden of chronic kidney disease attributable to high sodium intake: a longitudinal study in 1990–2019 in China.docx by Yongyao Shen (20561210)

“…Despite a slight decreasing trend exists, the absolute number increased as much as twofold, particularly among males and seniors. …”

Association of Ghrelin Gene Polymorphisms and Serum Ghrelin Levels with the Risk of Hepatitis B Virus-Related Liver Diseases in a Chinese Population by Xiaolian Zhang (76989)

“…In subgroup analysis by gender, binary logistic regression analyses adjusting for age showed that the GHRL rs26311 C allele and combined GC+CC genotypes were associated with a significantly increased risk to LC in males (C vs. …”

Table_1_Clinical Features and Risk Factors for Active Tuberculosis in Takayasu Arteritis: A Single-Center Case-Control Study.docx by Jiawei Zhou (235530)

“…Backgrounds<p>Takayasu arteritis (TAK) is a chronic, granulomatous vasculitis correlated with tuberculosis (TB). …”

Table_2_Identification of zona pellucida defects revealed a novel loss-of-function mutation in ZP2 in humans and rats.docx by Jun Zeng (403080)

“…All oocytes showed a thin or no ZP under a light microscope and were fertilized after ICSI. …”

Phenolic Compounds and Expression of <i>4CL</i> Genes in Silver Birch Clones and Pt4CL1a Lines by Suvi Sutela (521333)

“…<div><p>A small multigene family encodes 4-coumarate:CoA ligases (4CLs) catalyzing the CoA ligation of hydroxycinnamic acids, a branch point step directing metabolites to a flavonoid or monolignol pathway. …”

Image_1_Seizures regulate the cation-Cl− cotransporter NKCC1 in a hamster model of epilepsy: implications for GABA neurotransmission.JPEG by Juan-Manuel Bonet-Fernández (16415964)

“…Mounting evidence suggests that the impairment of GABAergic inhibitory neurotransmission plays a crucial role in the pathophysiology of epilepsy, both in patients and animal models. …”

Data_Sheet_1_Oral Contraceptive Use and Increased Risk of Stroke: A Dose–Response Meta-Analysis of Observational Studies.docx by Feng Li (30515)

“…<p>Background: Oral contraceptive (OCP) use might increase the risk of stroke in women. We examined a possible dose–response relation between OCP use and the risk of stroke in young and middle-aged women.…”

Table_1_Effects of Polarized Training on Cardiometabolic Risk Factors in Young Overweight and Obese Women: A Randomized-Controlled Trial.DOCX by Rafael Zapata-Lamana (5755763)

“…Relative fold changes in fasting plasma glucose concentrations decreased only in POL group (p = 0.002). Training induced a significant increase in relative fat oxidation in all the groups (time effect: p < 0.001). …”

Table_1_Parallel Loop Binding Compression Suture, a Modified Procedure for Pernicious Placenta Previa Complicated With Placenta Increta.DOCX by Mengdi Fu (11434708)

“…Additionally, neonatal outcomes were evaluated.</p><p>Results: A total of 124 patients were enrolled in the study, including 38 patients receiving parallel loop binding compression suture surgery in the study group, and 86 patients in the control group. …”

Image_6_Association Between Beta-Carotene Supplementation and Mortality: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.pdf by Graziamaria Corbi (2795578)

“…Background<p>Aging is a phenomenon universally involving all organisms, genetically determined, and epigenetically influenced by the environment. …”

Table_1_Identification of zona pellucida defects revealed a novel loss-of-function mutation in ZP2 in humans and rats.docx by Jun Zeng (403080)

“…All oocytes showed a thin or no ZP under a light microscope and were fertilized after ICSI. …”

Image_2_Association Between Beta-Carotene Supplementation and Mortality: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.TIFF by Graziamaria Corbi (2795578)

“…Background<p>Aging is a phenomenon universally involving all organisms, genetically determined, and epigenetically influenced by the environment. …”

Associations of Polymorphisms in <i>MTHFR</i> Gene with the Risk of Age-Related Cataract in Chinese Han Population: A Genotype-Phenotype Analysis by Xue-bin Wang (652491)

“…<div><p>Homocysteine (Hcy) is a potential risk factor for age-related cataract (ARC). …”

DNA Detection of <i>Schistosoma japonicum</i>: Diagnostic Validity of a LAMP Assay for Low-Intensity Infection and Effects of Chemotherapy in Humans by Jing Xu (15337)

“…The LAMP assay may provide a potential tool to support schistosomiasis control and elimination strategies.…”