First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC_0‑inf (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. Low-dose <b>35m</b> remarkably decreases LPS-induced IL-1β release both <i>in vitro</i> and <i>in vivo</i> by blocking the activation of NLRP3, indicating that <b>35m</b> can be a potential orally active therapeutic agent for the treatment of NLRP3-related diseases.…”

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC_0‑inf (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. Low-dose <b>35m</b> remarkably decreases LPS-induced IL-1β release both <i>in vitro</i> and <i>in vivo</i> by blocking the activation of NLRP3, indicating that <b>35m</b> can be a potential orally active therapeutic agent for the treatment of NLRP3-related diseases.…”

Gating strategy for flow cytometry. by Katie D. Pool (20141584)

Time-to-TKR as a function of number of courses of HA injection. by Roy Altman (839945)

Genetic characterization of <i>Mycoplasma pneumoniae</i> isolated in Osaka between 2011 and 2017: Decreased detection rate of macrolide-resistance and increase of <i>p1</i> gene ty... by Chihiro Katsukawa (6264050)

“…The remaining strain with an irregular typing pattern had a large deletion in the <i>p1</i> operon.</p></div>…”

Supplementary Material for: Adjunctive active vitamin D (AVD) decreases kidney function during treatment of secondary hyperparathyroidism (SHPT) with extended-release calcifediol (... by figshare admin karger (2628495)

CTS-treated MCF10A cell viability is time-dependent and serum-sensitive. by Rebecca J. Clifford (497197)

“…<p>A) MCF10A (dashed line) cells incubated with 500 nM ouabain showed a time-dependent decrease in viability during CTS treatment. …”

Seasonal vertical distribution of temperature and salinity around set net. by Yanhui Zhu (6697751)

Seasonal variation of fish distribution in horizontal structure expressed as the relationship between <i>Sa</i> (area backscattering strength) and <i>L</i> (distance from shore) ba... by Yanhui Zhu (6697751)

Entry probability as a function of and for . by Maria R. D'Orsogna (141837)

“…(c) When the initial and final states have larger degradation rates, a maximum as a function of arises for large . …”

Bcl-2 family mRNA expression in IL-17A and IFN-γ-treated monocyte-derived DC. by Selma Olsson Åkefeldt (282869)

“…<p>(<b>A,B</b>) DC at day 0 (None) or treated 12 days with IL-17A +/− IFN-γ. …”

Treatment with rPAF-AH decreases CFU numbers in the peritoneal fluid after CLP model. by Mariana G. A. Teixeira-da-Cunha (457653)

PI+ total immune cells are decreased at days 2, 5, and 14 following IR, and PI+ neutrophils are increased at day 30. by Jordan A. Gunning (18143970)

Disruption of poly-ADP-ribosylation decreases nucleolar CTCF, disrupts nucleolar structure, and increases <i>rDNA</i> expression. by Paola A. Guerrero (357587)

Decreased KIF4 expression suppressed HBV infection in HepG2-hNTCP and primary human hepatocytes (PHH). by Sameh A. Gad (12269979)

ATRA decreases mRNA expression of HO-1, GCLM and x-CT and lowers GSH level in BTZ-treated cells. by A. L. Furfaro (2587792)

Photoinactivation of PSD-95-4c decreases GluR2 staining with no changes in NR1 or TfR staining. by Guillermo A. Yudowski (102587)

“…Only GluR2 in the FlAsH group showed a significant decrease (16% ±5 <i>n</i> = 7). (C) PSD-95-4c distribution was not changes after FALI. …”

Local inhibition of nitrergic activity in tenotomized rats accelerates muscle regeneration by increasing fiber area and decreasing central core lesions by A.D. Seabra (6515330)

“…<div><p>Muscular atrophy is a progressive degeneration characterized by muscular proteolysis, loss of mass and decrease in fiber area. …”

Erratum: Lipopolysaccharide-Induced Sickness Behavior in Lactating Rats Decreases Ultrasonic Vocalizations and Exacerbates Immune System Activity in Male Offspring by Nascimento A.F. (4273759)

Plasma membrane localized KCa3.1 is decreased by DN Rab1 and Rab8, but not by Rab2 or Rab6. by Claudia A. Bertuccio (309866)

“…<p>HEK293 cells were co-transfected with BLAP-KCa3.1 and either WT, DA or DN Rabs 1, 2, 6 or 8 and plasma membrane localized KCa3.1 evaluated by specific biotinylation, streptavidin labeling and IB (see Methods). As shown in <b>A</b> and <b>C</b>, DN Rab8 (T22N) and two different DN Rab1s (N124I, S25N) decreased expression of plasma membrane KCa3.1. …”