Image_3_Nicotinamide Increases Intracellular NAD+ Content to Enhance Autophagy-Mediated Group A Streptococcal Clearance in Endothelial Cells.TIF by Cheng-Lu Hsieh (5591168)

“…Moreover, the NAD⁺ content and NAD⁺/NADH ratio of GAS-infected endothelial cells were dramatically increased, whereas the cell cytotoxicity was decreased by exogenous nicotinamide treatment. After knockdown of the autophagy-related ATG9A, the intracellular bacterial load was increased in nicotinamide-treated endothelial cells. …”

Table 4_Retrograde inferior vena cava perfusion reduces the risk of acute kidney injury depending on the oxygen extraction ratio. A retrospective cohort study.docx by Xinyi Liao (10889523)

“…In regression analysis, ACP + RIVP was associated with lower risk of AKI than ACP alone (adjusted OR 0.229; 95% CI 0.071–0.746). RIVP at a pressure of 22.5 ± 3.8 mmHg delivered 0.98 ± 0.34 ml/min/kg of oxygen to the lower body, and the partial oxygen pressure decreased from 359 ± 57 mmHg in RIVP blood to 64 ± 30 mmHg in returning blood. …”

Image_2_Nicotinamide Increases Intracellular NAD+ Content to Enhance Autophagy-Mediated Group A Streptococcal Clearance in Endothelial Cells.TIF by Cheng-Lu Hsieh (5591168)

“…Moreover, the NAD⁺ content and NAD⁺/NADH ratio of GAS-infected endothelial cells were dramatically increased, whereas the cell cytotoxicity was decreased by exogenous nicotinamide treatment. After knockdown of the autophagy-related ATG9A, the intracellular bacterial load was increased in nicotinamide-treated endothelial cells. …”

Image_1_Gut Commensal Fungi Protect Against Acetaminophen-Induced Hepatotoxicity by Reducing Cyp2a5 Expression in Mice.pdf by Zhuoen He (13030452)

“…Background and Aims<p>Drug-induced liver injury (DILI) is a common cause of acute liver failure and represents a significant global public health problem. …”

Association of glycemic control and chronic kidney disease with hospitalization in type 2 diabetes in a cross-sectional study in Region Halland by Bertin Magamba (22755273)

“…<p>To examine the separate associations of glycemic control and chronic kidney disease with hospitalization days over one year in patients with type 2 diabetes (T2D).</p> <p>A cross-sectional study using retrospective data on T2D patients in Region Halland, Sweden, during 2020. …”

MicroRNA Let-7a Inhibits Proliferation of Human Prostate Cancer Cells <em>In Vitro</em> and <em>In Vivo</em> by Targeting E2F2 and CCND2 by Qingchuan Dong (250327)

“…</p><h3>Methodology/Principal</h3><p>Findings Real-time RT-PCR demonstrated that decreased levels of let-7a are present in resected prostate cancer samples and prostate cancer cell lines. …”

Image 5_EPHA2 promotes triple-negative breast cancer progression by suppressing pyroptosis via the AKT/PI3K/mTOR pathway.tif by Xiaoying Huang (328697)

“…Additionally, we observed a decreased expression of ferroptosis-associated marker named SLC7A11, suggesting that this transporter may mediate the effects of AKT inhibition on pyroptosis.…”

Increase of aortic diameters and decrease of circumferential strains over time. by Bram Trachet (526773)

DataSheet_2_The predictive value of free thyroxine combined with tubular atrophy/interstitial fibrosis for poor prognosis in patients with IgA nephropathy.csv by Bixia Yang (18550324)

“…Background<p>IgA nephropathy (IgAN), the most common type of glomerulonephritis, has great individual differences in prognosis. …”

Table 1_LpxR and PagL expression in live attenuated auxotrophic Pseudomonas aeruginosa vaccines modulates lipid A reactogenicity in vitro while preserving immunogenicity.docx by Miriam Moscoso (345679)

“…Introduction<p>Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen responsible for severe respiratory tract infections. …”

Data_Sheet_1_Differentiation-Dependent Regulation of Human Endogenous Retrovirus K Sequences and Neighboring Genes in Germ Cell Tumor Cells.pdf by Thomas Mueller (33067)

“…A similar pattern was found for PRODH. Differentiation of EC cells by siRNA mediated knock-down of OCT4 or treatment with differentiation inducing medium decreased expression of HERVK and PRODH. …”

DataSheet_1_The predictive value of free thyroxine combined with tubular atrophy/interstitial fibrosis for poor prognosis in patients with IgA nephropathy.docx by Bixia Yang (18550324)

“…Background<p>IgA nephropathy (IgAN), the most common type of glomerulonephritis, has great individual differences in prognosis. …”

lncRNA KCNQ1OT1 reverses the effect of sevoflurane on hepatocellular carcinoma progression via regulating the miR-29a-3p/CBX3 axis by Weifu Zhou (12728095)

“…We found that the levels of KCNQ1OT1 and CBX3 were decreased, while miR-29a-3p was increased in SEVO-treated HCC cells. …”

Data_Sheet_1_Extracellular Superoxide Dismutase (EC-SOD) Regulates Gene Methylation and Cardiac Fibrosis During Chronic Hypoxic Stress.pdf by Ayan Rajgarhia (10898844)

“…<p>Chronic hypoxic stress induces epigenetic modifications mainly DNA methylation in cardiac fibroblasts, inactivating tumor suppressor genes (RASSF1A) and activating kinases (ERK1/2) leading to fibroblast proliferation and cardiac fibrosis. …”

Table 1_Genetic variants in the vitamin D pathway genes are predictors of the risk of diabetic kidney disease in Central Asian Kazakhstani cohort with type 2 diabetes.docx by Binura Taurbekova (21692555)

“…Likewise, the GC rs4588 T/T genotype was strongly associated with a decreased risk of DKD under the recessive (AOR = 0.30, 95% CI: 0.10–0.88) and codominant (AOR = 0.28, 95% CI: 0.09–0.85) models. …”

Data_Sheet_1_Nicotinamide Increases Intracellular NAD+ Content to Enhance Autophagy-Mediated Group A Streptococcal Clearance in Endothelial Cells.pdf by Cheng-Lu Hsieh (5591168)

“…Moreover, the NAD⁺ content and NAD⁺/NADH ratio of GAS-infected endothelial cells were dramatically increased, whereas the cell cytotoxicity was decreased by exogenous nicotinamide treatment. After knockdown of the autophagy-related ATG9A, the intracellular bacterial load was increased in nicotinamide-treated endothelial cells. …”

Stress can increase or decrease anxiety depending on the timing of the stressor by Jason Snyder (96580)

Histone antibodies and polysialic acid decrease NET-mediated cytotoxicity. by Mona Saffarzadeh (180792)

“…<p>(A) NET were pre-incubated with different antibodies against histones (DNA/H1, H2A, H2B, H3, citrullinated H3 [cit H3], H4) or with isotype-matched control antibodies. …”

Turns decrease the likelihood of interneuron evoked reversals, except for AVA. by Sandeep Kumar (145759)

Analysis of the interactions observed in four domains of the wt NP and R361A mutant. by Bogdan Tarus (334949)

“…</p>c)<p><u>Linker-β sheet 1 contacts</u>: The linker was connected to the β sheet 1 through conserved hydrophobic interaction between M371 and the ring of Y97, stable hydrogen bonds between R106 and the linker backbone oxygen atoms. The R361A mutation decreased the population of the solvated K103-E372 salt-bridge.…”