Rv2346c enhances mycobacterial survival within macrophages by inhibiting TNF-α and IL-6 production via the p38/miRNA/NF-κB pathway by Jing Yao (169854)

“…<p>The intracellular survival of <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>) has a central role in the pathogenesis of tuberculosis. …”

Image 1_Myristic acid beneficially modulates intervertebral disc degeneration by preventing endplate osteochondral remodeling and vertebral osteoporosis in naturally aged mice.pdf by Yan Gong (103494)

“…Additionally, MA notably inhibited osteoclast activity, as evidenced by a decrease in the number of osteoclasts and a significant suppression of F-actin formation. …”

Image 1_Linkage of jockey falls and injuries with racehorse injuries and fatalities in Thoroughbred flat racing in Victoria, Australia.pdf by Ashleigh V. Morrice-West (17273977)

“…</p>Results<p>The incidence of MSI was 21.21 (20.84, 21.59), racehorse fatalities 0.55 (0.50, 0.61), jockey falls was 3.01 (2.80, 3.24), and jockey injuries 1.79 (1.63, 1.97) per 1000 flat race starts. There was a decrease in racehorse MSI and jockey falls over the study period but no change in racehorse fatality or jockey injury incidence. …”

The Depsipeptide Romidepsin Reverses HIV-1 Latency <i>In Vivo</i> by Ole S. Søgaard (148120)

“…<div><p>Pharmacologically-induced activation of replication competent proviruses from latency in the presence of antiretroviral treatment (ART) has been proposed as a step towards curing HIV-1 infection. However, until now, approaches to reverse HIV-1 latency in humans have yielded mixed results. …”

(S)-2 induced apoptosis in LNCaP cells. by Anna Laurenzana (296271)

“…Mitochondrial depolarization is indicated by a decrease in the red/green (R/G) fluorescence intensity ratio <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0058267#pone.0058267-Salvioli1" target="_blank">[32]</a>. …”

<b>The Influence of Pre-Exposure to Marine Heatwaves on the Critical Thermal Maxima (CT</b>_{<strong>max</strong>}<b>) of Marine Foundation Species</b> by Nathan King (8559951)

“…Following a four-week MHW simulation, individuals were subjected to a CT_max trial, where temperatures were raised by 2°C day^-1 until physiological end-points were reached. …”

Identifying the Basal Ganglia Network Model Markers for Medication-Induced Impulsivity in Parkinson's Disease Patients by Pragathi Priyadharsini Balasubramani (749707)

“…Computational modeling suggested that PD-OFF patients have higher punishment sensitivity, while healthy controls showed comparatively higher risk sensitivity. A significant decrease in sensitivity to punishment and risk was crucial for explaining behavioral changes observed in PD-ON ICD patients. …”

Table_1_Gender Differences in 3-Month Outcomes of Erenumab Treatment—Study on Efficacy and Safety of Treatment With Erenumab in Men.DOCX by Raffaele Ornello (5213582)

“…<p>Objective: We reported gender-specific data on the efficacy and safety of erenumab, a monoclonal antibody antagonizing the calcitonin gene-related peptide (CGRP) receptor.…”

Village-Randomized Clinical Trial of Home Distribution of Zinc for Treatment of Childhood Diarrhea in Rural Western Kenya by Daniel R. Feikin (153640)

“…In rural Africa, most children with diarrhea are not brought to health facilities. In a village-randomized trial in rural Kenya, we assessed if zinc treatment might have a community-level preventive effect on diarrhea incidence if available at home versus only at health facilities.…”

<i>FoxO6</i> regulates Hippo signaling and growth of the craniofacial complex by Zhao Sun (283073)

“…<i>FoxO6</i>^<i>-/-</i> mice have significantly reduced Hippo Signaling caused by a decrease in <i>Lats1</i> expression and decreases in <i>Shh</i> and <i>Runx2</i> expression, suggesting that <i>Shh</i> and <i>Runx2</i> are also linked to Hippo signaling. …”

Table1_Transcriptional time course after rotator cuff repair in 6 month old female rabbits.DOCX by Laura S. Vasquez-Bolanos (11242737)

“…Many were also significantly enriched at 2 weeks, with the addition of NIF/NF-kappaB signaling, transcription in response to hypoxia, and mRNA stability alongside many additional pathways. There was also a shift in transcriptional activity at 4 weeks post-repair with significantly enriched pathways for lipids, hormones, apoptosis, and cytokine activity, despite an overall decrease in the number of differentially expressed genes. …”

Co-immunoprecipitation and BiFC experiments related to Abd-B and Exd interaction. by Jesús R. Curt (20553231)

“…Protein present in the co-IPs is indicated above the gels. There is a significant decrease in the amount of the Abd-B^W protein captured on the resin when compared to the Abd-B wildtype protein (24%), while Exd remains almost unchanged (2%). …”

Tissue-Specific Suppression of Thyroid Hormone Signaling in Various Mouse Models of Aging by W. Edward Visser (280330)

“…A strong induction of TH-inactivating deiodinase D3 and decrease of TH-activating D1 activities are observed in <i>Csb</i>^<i>m/m</i><i>/Xpa</i>^<i>-/-</i> livers. …”

Table_2_The Impact of Hippocampal Sex Hormones Receptors in Modulation of Depressive-Like Behavior Following Chronic Anabolic Androgenic Steroids and Exercise Protocols in Rats.XLS... by Dragica Selakovic (4068406)

“…<p>The aim of this study was to evaluate alterations in depressive-like behaviors in rats following chronic administration of a supraphysiological dose of anabolic androgenic steroids (AASs) as well as exposure to a prolonged exercise protocol. …”

Image_3_CISD2 Promotes Resistance to Sorafenib-Induced Ferroptosis by Regulating Autophagy in Hepatocellular Carcinoma.tif by Bowen Li (200859)

“…Knockdown of CISD2 promoted a decrease in the viability of drug-resistant HCC cells. …”

The PND mediates blue light/Ubr1-dependent loss of yEmRFP-associated fluorescence in yeast. by Leslie M. Stevens (7553234)

“…Yeast expressing <i>PND-yEmRFP</i> in the presence of Ubr1p, exhibited a dramatic decrease in response to illumination <b>(C, D)</b>. …”

S1 Dataset - by Yael Appelboom (20570815)

“…Mental effort rose from 17h onwards higher values, whereas a decrease in comfortability was seen from 21h onwards.…”

Sexual fate change of mutant XX germ cells was not accompanied by somatic sex reprogramming. by Quan Wu (444646)

“…Genes located right of the rightmost dotted red line show more than a 1.5-fold increase in DKO, and genes located left of the leftmost dotted red line show less than a 1.5-fold decrease in DKO compared with control ovaries. …”

Defining Hypo-Methylated Regions of Stem Cell-Specific Promoters in Human iPS Cells Derived from Extra-Embryonic Amnions and Lung Fibroblasts by Koichiro Nishino (219736)

“…Thus, a group of genes becomes active through a decrease of methylation in their promoters. …”

Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation by Daniela De Stefano (131144)

“…In a pilot clinical trial involving 10 <i>F508del-CFTR</i> homozygous CF patients, the combination of cysteamine and EGCG restored BECN1, reduced SQSTM1 levels and improved CFTR function from nasal epithelial cells <i>in vivo</i>, correlating with a decrease of chloride concentrations in sweat, as well as with a reduction of the abundance of <i>TNF/TNF-alpha (tumor necrosis factor)</i> and <i>CXCL8</i> (<i>chemokine [C-X-C motif] ligand 8</i>) transcripts in nasal brushing and TNF and CXCL8 protein levels in the sputum. …”