Image_2_m6A mRNA Methylation Regulates Epithelial Innate Antimicrobial Defense Against Cryptosporidial Infection.tif by Zijie Xia (3772114)

“…Specifically, expression levels of immune-related genes, such as the immunity-related GTPase family M member 2 and interferon gamma induced GTPase, are increased in infected cells with a decreased m⁶A mRNA methylation. Our data support that intestinal epithelial cells display significant alterations in the topology of their m⁶A mRNA methylome in response to C. parvum infection with the involvement of activation of the NF-кB signaling pathway, a process that modulates expression of specific immune-related genes and contributes to fine regulation of epithelial antimicrobial defense.…”

Table_1_m6A mRNA Methylation Regulates Epithelial Innate Antimicrobial Defense Against Cryptosporidial Infection.xlsx by Zijie Xia (3772114)

“…Specifically, expression levels of immune-related genes, such as the immunity-related GTPase family M member 2 and interferon gamma induced GTPase, are increased in infected cells with a decreased m⁶A mRNA methylation. Our data support that intestinal epithelial cells display significant alterations in the topology of their m⁶A mRNA methylome in response to C. parvum infection with the involvement of activation of the NF-кB signaling pathway, a process that modulates expression of specific immune-related genes and contributes to fine regulation of epithelial antimicrobial defense.…”

Voltage-dependent inward currents in smooth muscle cells of skeletal muscle arterioles by Alexandra V. Ulyanova (5142920)

“…The magnitude of TTX-sensitive currents recorded with 140 mM Na⁺ was about 20 pA/pF. TTX-sensitive currents decreased five-fold when Ca²⁺ increased from 2 to 10 mM. …”

Table_3_m6A mRNA Methylation Regulates Epithelial Innate Antimicrobial Defense Against Cryptosporidial Infection.xlsx by Zijie Xia (3772114)

“…Specifically, expression levels of immune-related genes, such as the immunity-related GTPase family M member 2 and interferon gamma induced GTPase, are increased in infected cells with a decreased m⁶A mRNA methylation. Our data support that intestinal epithelial cells display significant alterations in the topology of their m⁶A mRNA methylome in response to C. parvum infection with the involvement of activation of the NF-кB signaling pathway, a process that modulates expression of specific immune-related genes and contributes to fine regulation of epithelial antimicrobial defense.…”

Table_1_ZC3H11A loss of function enhances NF-κB signaling through defective IκBα protein expression.docx by Mahmoud Darweesh (8058308)

“…IL-6 upregulation in the absence of the ZC3H11A protein correlated with an increased NF-κB transcription factor binding to the IL-6 promoter and decreased IL-6 mRNA decay. …”

Table_2_m6A mRNA Methylation Regulates Epithelial Innate Antimicrobial Defense Against Cryptosporidial Infection.xlsx by Zijie Xia (3772114)

“…Specifically, expression levels of immune-related genes, such as the immunity-related GTPase family M member 2 and interferon gamma induced GTPase, are increased in infected cells with a decreased m⁶A mRNA methylation. Our data support that intestinal epithelial cells display significant alterations in the topology of their m⁶A mRNA methylome in response to C. parvum infection with the involvement of activation of the NF-кB signaling pathway, a process that modulates expression of specific immune-related genes and contributes to fine regulation of epithelial antimicrobial defense.…”

image_4_Complement Activation During Ischemia/Reperfusion Injury Induces Pericyte-to-Myofibroblast Transdifferentiation Regulating Peritubular Capillary Lumen Reduction Through pER... by Giuseppe Castellano (5258120)

“…Treatment by C1-inhibitor (C1-INH) significantly preserved the phenotype of pericytes maintaining microvascular density and capillary lumen area at tubulointerstitial level. In vitro, C5a transdifferentiated human pericytes in myofibroblasts, with increased αSMA expression in stress fibers, collagen I production, and decreased antifibrotic protein Id2. …”

Image_3_m6A mRNA Methylation Regulates Epithelial Innate Antimicrobial Defense Against Cryptosporidial Infection.tif by Zijie Xia (3772114)

“…Specifically, expression levels of immune-related genes, such as the immunity-related GTPase family M member 2 and interferon gamma induced GTPase, are increased in infected cells with a decreased m⁶A mRNA methylation. Our data support that intestinal epithelial cells display significant alterations in the topology of their m⁶A mRNA methylome in response to C. parvum infection with the involvement of activation of the NF-кB signaling pathway, a process that modulates expression of specific immune-related genes and contributes to fine regulation of epithelial antimicrobial defense.…”

Protein synthesis inhibition induces <i>mtl-1</i> expression in response to deregulated Ca²⁺ homeostasis. by Hans M. Dalton (5532668)

“…<p>(<i>A</i>-<i>B</i>) Organismal expression of <i>mtl-1</i> is increased while <i>mtl-2</i> is decreased in response to protein synthesis inhibition generated by RNAi in all cells (solid bars), hypodermal-specific RNAi (Hyp), or the germline-specific RNAi (Ger), but not the intestine-specific RNAi (Int) (<i>A</i>); this expression is more pronounced after 5 days (120hr) in the arrested state (<i>B</i>) (3 biological replicates). …”

Genistein Inhibits Prostate Cancer Cell Growth by Targeting miR-34a and Oncogenic HOTAIR by Takeshi Chiyomaru (140914)

“…Knockdown (siRNA) of HOTAIR decreased PCa cell proliferation, migration and invasion and induced apoptosis and cell cycle arrest. miR-34a was also up-regulated by genistein and may directly target HOTAIR in both PC3 and DU145 PCa cells.…”

DataSheet_1_Epigenetic therapy reprograms M2-type tumor-associated macrophages into an M1-like phenotype by upregulating miR-7083-5p.docx by Sri Murugan Poongkavithai Vadevoo (14158275)

“…<p>Reprogramming M2-type, pro-tumoral tumor-associated macrophages (TAMs) into M1-type, anti-tumoral macrophages is a key strategy in cancer therapy. In this study, we exploited epigenetic therapy using the DNA methylation inhibitor 5-aza-2’-deoxycytidine (5-aza-dC) and the histone deacetylation inhibitor trichostatin A (TSA), to reprogram M2-type macrophages into an M1-like phenotype. …”

Change in Adverse Events After Enrollment in the National Surgical Quality Improvement Program: A Systematic Review and Meta-Analysis by Joshua Montroy (848622)

“…Studies evaluating other adverse events noted decreased incidence following NSQIP participation and implementation of a formal quality improvement program.…”

Table_6_Total Flavonoids of Chuju Decrease Oxidative Stress and Cell Apoptosis in Ischemic Stroke Rats: Network and Experimental Analyses.docx by Cong Wang (107450)

“…TFCJ is a promising authentic traditional Chinese medicine for the management of IS.…”

Table_2_Total Flavonoids of Chuju Decrease Oxidative Stress and Cell Apoptosis in Ischemic Stroke Rats: Network and Experimental Analyses.docx by Cong Wang (107450)

“…TFCJ is a promising authentic traditional Chinese medicine for the management of IS.…”

Table_1_Total Flavonoids of Chuju Decrease Oxidative Stress and Cell Apoptosis in Ischemic Stroke Rats: Network and Experimental Analyses.docx by Cong Wang (107450)

“…TFCJ is a promising authentic traditional Chinese medicine for the management of IS.…”

Table_5_Total Flavonoids of Chuju Decrease Oxidative Stress and Cell Apoptosis in Ischemic Stroke Rats: Network and Experimental Analyses.docx by Cong Wang (107450)

“…TFCJ is a promising authentic traditional Chinese medicine for the management of IS.…”

Table_3_Total Flavonoids of Chuju Decrease Oxidative Stress and Cell Apoptosis in Ischemic Stroke Rats: Network and Experimental Analyses.docx by Cong Wang (107450)

“…TFCJ is a promising authentic traditional Chinese medicine for the management of IS.…”

Table_4_Total Flavonoids of Chuju Decrease Oxidative Stress and Cell Apoptosis in Ischemic Stroke Rats: Network and Experimental Analyses.docx by Cong Wang (107450)

“…TFCJ is a promising authentic traditional Chinese medicine for the management of IS.…”

Blockade by A_2AR antagonists of the motor output induced by cortical electrical stimulation. by Marco Orru (5653348)

“…<p>Dose-dependent decrease in the Power Correlation Coefficient (PCC) induced by the administration of different A_2AR antagonists. …”

Transfection of inhibitors decrease their corresponding endogenous miRNAs and transfection of mimics increase corresponding miRNAs in SHSY5Y cells. by Yang-ja Lee (125845)