Over-expression of an active S6K1 mutant enhances superoxide, decreases NO production and induces premature senescence in young endothelial cells. by Angana G. Rajapakse (352945)

Image_1_Specnuezhenide Decreases Interleukin-1β-Induced Inflammation in Rat Chondrocytes and Reduces Joint Destruction in Osteoarthritic Rats.TIF by Chiyuan Ma (702577)

“…Furthermore, SPN treatment prevents the degeneration of both cartilage and subchondral bone in a rat model of OA. To the best of our knowledge, this study is the first to report that SPN decreases interleukin-1β-induced inflammation in rat chondrocytes by inhibiting the activation of the NF-κB and wnt/β-catenin pathways, and, thus, has therapeutic potential in the treatment of OA.…”

Image_1_Specnuezhenide Decreases Interleukin-1β-Induced Inflammation in Rat Chondrocytes and Reduces Joint Destruction in Osteoarthritic Rats.TIF by Chiyuan Ma (702577)

“…Furthermore, SPN treatment prevents the degeneration of both cartilage and subchondral bone in a rat model of OA. To the best of our knowledge, this study is the first to report that SPN decreases interleukin-1β-induced inflammation in rat chondrocytes by inhibiting the activation of the NF-κB and wnt/β-catenin pathways, and, thus, has therapeutic potential in the treatment of OA.…”

Transcript levels for inflammatory markers were decreased in adipose tissue from Western diet (WD)-fed PIF1 KO females. by Frances R. Belmonte (6743618)

Lethality from cecal ligation and puncture (CLP) is decreased in BALB/c mice administered an anti-RAGE monoclonal antibody (mAb) by Emily C Lutterloh (87191)

Lack of SOD activity in strain CAM.02 decreases intracellular H₂O₂ levels. by Tiago Beites (195644)

Circulating PDC show decreased responses to SIV inversely correlated with the increased prevalence of Ki67⁺ pDC precursors. by Timothée Bruel (337070)

BXL0124 represses invasion markers and decreases protein levels of CD44 and pSTAT3 in MCF10DCIS cells. by Jae Young So (289590)

Microbial community in the simulated wastewater sample with different inoculates at the optimum voltage before and after culture at the phylum level (R0, A0 and S0 respectively pre... by Han Li (10885)

Homozygous deletion of <i>ERG251</i> leads to increased sensitivity to cell membrane and osmotic stress but decreased sensitivity to oxidative stress. by Xin Zhou (54275)

“…<p><b>A</b>. Volcano plot for differentially expressed genes (log₂ fold change ≥ 1 or ≤-1 and adjusted <i>p</i>-value < 0.05) in the <i>erg251Δ/Δ</i> mutant compared to <i>ERG251/ERG251</i> in YPAD. …”

DLL1 downregulation impairs Notch pathway activation in BC cells and decreases MCF-7 and BT474 colony formation abilities. by Joana Sales-Dias (6714560)

Neutrophils from HIV-infected individuals with high CD4 T-cell count have increased IL-10 activity and decreased glycolysis. by Garett Dunsmore (11021169)

<i>Drosophila</i> DJ-1 Decreases Neural Sensitivity to Stress by Negatively Regulating Daxx-Like Protein through dFOXO by Soojin Hwang (399080)

Decreased deposition but normal distribution of axis proteins in <i>red1</i>_<i>ycs4S</i> mutants. by Tovah E. Markowitz (4278937)

PLCε lacking the CDC25 domain and lipase activity cannot rescue monolayer integrity and decreased active Rap1 levels. by Peter V. DiStefano (3111639)

2-AAPA decreases H/R induced apoptosis in mitoNEET-KD cells and increases mitoNEET-protein despite KD. by Anika Habener (3165984)

“…<p>(A) Western Blot analysis of activated caspase-3 revealed reduced apoptosis in 2-AAPA treated mitoNEET-KD cells to the same level seen in 2-AAPA treated HL-1 cells after H/R (n = 6). …”

PD-1/CTLA-4 blockade decreases the number of latently, and lytically, EBV-infected B cells in cord-blood humanized mice. by Shi-Dong Ma (2746609)

Decreased peripheral Foxp3⁺ Tregs in both intact NIK KO and NIK KO single BM chimeric mice. by Susan E. Murray (461317)

Early HCV infection enhanced cell survival signaling pathways associated with TGF-β in hepatocytes while phosphorylated Gab1 decreased. by Da-eun Nam (18927946)

Strains carrying different <i>ELP3</i> mutant alleles show decreased telomeric gene silencing and increased HU sensitivity. by Changchun Chen (139128)