Impaired muscle function in <i>dy</i>^<i>2J</i><i>/dy</i>^<i>2J</i> mice. by S. Pasteuning-Vuhman (4348486)

“…<p><b>(a)</b> A lower body weight (<i>P</i><0.01) was detected in <i>dy</i>^<i>2J</i><i>/dy</i>^<i>2J</i> mice when compared to wild type mice. …”

Asporin-deficient mice have tougher skin and altered skin glycosaminoglycan content and structure by Marco Maccarana (429522)

“…The glycosaminoglycan content and structure in <i>Aspn</i>^<i>-/-</i> skin was profoundly altered: chondroitin/dermatan sulfate was more than doubled and had an altered composition, while heparan sulfate was halved and had a decreased sulfation. Also, decorin and biglycan were doubled in <i>Aspn</i>^<i>-/-</i> skin. …”

Image_1_Circulating microRNA Expression Profiling Identifies miR-125a-5p Promoting T Helper 1 Cells Response in the Pathogenesis of Hashimoto's Thyroiditis.TIFF by Yingzhao Liu (8959862)

“…Interestingly, knockdown of miR-125a-5p in CD4⁺ T cells resulted in an elevated level of MAF but decreased the proportion of Th1 cells and the transcript level of IFN-γ in vitro. …”

DataSheet_1_Oropharyngeal microbial ecosystem perturbations influence the risk for acute respiratory infections in common variable immunodeficiency.docx by Federica Pulvirenti (8262402)

“…</p>Conclusions<p>CVID patients showed a perturbed oropharynx microbiota enriched with potentially pathogenic bacteria and decreased protective species. …”

Image_1_Long-Term Persistence and Relevant Therapeutic Impact of High-Titer Viral-Neutralizing Antibody in a Convalescent COVID-19 Plasma Super-Donor: A Case Report.jpg by Mafalda De Rienzo (11312694)

“…Anti-SARS-CoV-2 antibody levels steadily decreased. No correlation was found between anti-S/anti-N IgG and IgM levels and viral NT, measured by either a microneutralization test or the surrogate RBD/ACE2-binding inhibition test. …”

Data_Sheet_1_Transcriptome Analyses of β-Thalassemia −28(A>G) Mutation Using Isogenic Cell Models Generated by CRISPR/Cas9 and Asymmetric Single-Stranded Oligodeoxynucleotides (ass... by Jing Li (10611)

“…We found that the HBB −28(A>G) mutation not only disturbed the transcription of HBB, but also decreased the expression of HBG, which may further aggravate the thalassemia phenotype and partially explain the more severe clinical outcome of β-thalassemia patients with the HBB −28(A>G) mutation. …”

Image_2_Long-Term Persistence and Relevant Therapeutic Impact of High-Titer Viral-Neutralizing Antibody in a Convalescent COVID-19 Plasma Super-Donor: A Case Report.jpg by Mafalda De Rienzo (11312694)

“…Anti-SARS-CoV-2 antibody levels steadily decreased. No correlation was found between anti-S/anti-N IgG and IgM levels and viral NT, measured by either a microneutralization test or the surrogate RBD/ACE2-binding inhibition test. …”

Image_3_Circulating microRNA Expression Profiling Identifies miR-125a-5p Promoting T Helper 1 Cells Response in the Pathogenesis of Hashimoto's Thyroiditis.TIFF by Yingzhao Liu (8959862)

“…Interestingly, knockdown of miR-125a-5p in CD4⁺ T cells resulted in an elevated level of MAF but decreased the proportion of Th1 cells and the transcript level of IFN-γ in vitro. …”

Image_2_Circulating microRNA Expression Profiling Identifies miR-125a-5p Promoting T Helper 1 Cells Response in the Pathogenesis of Hashimoto's Thyroiditis.TIFF by Yingzhao Liu (8959862)

“…Interestingly, knockdown of miR-125a-5p in CD4⁺ T cells resulted in an elevated level of MAF but decreased the proportion of Th1 cells and the transcript level of IFN-γ in vitro. …”

Image_3_Long-Term Persistence and Relevant Therapeutic Impact of High-Titer Viral-Neutralizing Antibody in a Convalescent COVID-19 Plasma Super-Donor: A Case Report.tif by Mafalda De Rienzo (11312694)

“…Anti-SARS-CoV-2 antibody levels steadily decreased. No correlation was found between anti-S/anti-N IgG and IgM levels and viral NT, measured by either a microneutralization test or the surrogate RBD/ACE2-binding inhibition test. …”

Image_3_CD8+ T Cells Form the Predominant Subset of NKG2A+ Cells in Human Lung Cancer.TIF by Yongyuan Chen (8319612)

“…In contrast, the NKG2A⁺ NK cells were decreased in tumors compared with the paired normal lung tissue. …”

Image_2_CD8+ T Cells Form the Predominant Subset of NKG2A+ Cells in Human Lung Cancer.TIF by Yongyuan Chen (8319612)

“…In contrast, the NKG2A⁺ NK cells were decreased in tumors compared with the paired normal lung tissue. …”

table_2_Meta-Analysis of Autoimmune Regulator-Regulated Genes in Human and Murine Models: A Novel Human Model Provides Insights on the Role of Autoimmune Regulator in Regulating ST... by Thomas R. J. Lovewell (739674)

“…In this study, we generated a recombinant AIRE expression variant of the TEC 1A3 human cell line, TEC 1A3 AIRE^hi, to determine genes targeted by AIRE, and using microarray analysis, we identified 482 genes showing significant differential expression (P < 0.05; false discovery rate <5%), with 353 upregulated and 129 downregulated by AIRE expression. …”

Nocturnal leg cramps: Prevalence and associations with demographics, sleep disturbance symptoms, medical conditions, and cardiometabolic risk factors by Michael A. Grandner (4090267)

“…NLC increased with age, lower education, unemployment, shorter sleep duration, all assessed sleep symptoms (nocturnal "leg jerks", snoring, snorting/gasping, difficulty falling asleep, difficulty maintaining sleep, non-restorative sleep, sleepiness, use of sleep medications), higher BMI, smoking, medical history (hypertension, heart failure, angina, stroke, arthritis, respiratory disease, and cancer), depression symptoms, and biomarkers (CRP, HbA1c, calcium, cadmium, red blood cells). Stepwise analysis showed that moderate-severe nocturnal leg cramps were associated with (in decreasing order of partial R²): leg jerks, poor overall health, arthritis, difficulty falling asleep, age, nonrestorative sleep, red blood cell count, lower education, angina, and difficulty maintaining sleep.…”

image_2_Meta-Analysis of Autoimmune Regulator-Regulated Genes in Human and Murine Models: A Novel Human Model Provides Insights on the Role of Autoimmune Regulator in Regulating ST... by Thomas R. J. Lovewell (739674)

“…In this study, we generated a recombinant AIRE expression variant of the TEC 1A3 human cell line, TEC 1A3 AIRE^hi, to determine genes targeted by AIRE, and using microarray analysis, we identified 482 genes showing significant differential expression (P < 0.05; false discovery rate <5%), with 353 upregulated and 129 downregulated by AIRE expression. …”

Image1_LncRNA VPS9D1-AS1 Promotes Malignant Progression of Lung Adenocarcinoma by Targeting miRNA-30a-5p/KIF11 Axis.tif by Jiefeng Liu (9194412)

“…</p><p>Results: VPS9D1-AS1 and KIF11 were increased in LUAD, whereas miRNA-30a-5p was decreased. VPS9D1-AS1 promoted the malignant progression of LUAD cells and could sponge miRNA-30a-5p. …”

Analysing mHealth usage logs in RCTs: Explaining participants’ interactions with type 2 diabetes self-management tools by Meghan Bradway (5703473)

“…We use the logs collected by persons with type 2 diabetes during a randomized controlled trial (RCT) as a use-case.…”

table_1_Meta-Analysis of Autoimmune Regulator-Regulated Genes in Human and Murine Models: A Novel Human Model Provides Insights on the Role of Autoimmune Regulator in Regulating ST... by Thomas R. J. Lovewell (739674)

“…In this study, we generated a recombinant AIRE expression variant of the TEC 1A3 human cell line, TEC 1A3 AIRE^hi, to determine genes targeted by AIRE, and using microarray analysis, we identified 482 genes showing significant differential expression (P < 0.05; false discovery rate <5%), with 353 upregulated and 129 downregulated by AIRE expression. …”

Table1_LncRNA VPS9D1-AS1 Promotes Malignant Progression of Lung Adenocarcinoma by Targeting miRNA-30a-5p/KIF11 Axis.xlsx by Jiefeng Liu (9194412)

“…</p><p>Results: VPS9D1-AS1 and KIF11 were increased in LUAD, whereas miRNA-30a-5p was decreased. VPS9D1-AS1 promoted the malignant progression of LUAD cells and could sponge miRNA-30a-5p. …”

Cross sectional study of mode of delivery and maternal and perinatal outcomes in mainland China by Lei Hou (274359)

“…Compared to SVD, antepartum non-indicated CD was associated with a decreased likelihood of post-partum hemorrhage (PPH) (aOR = 0.80, CI = 0.69–0.92) and was not associated with maternal death or combined severe outcomes (maternal death, transfusion, or hysterectomy). …”