Silencing of MINK significantly reduced EV71 replication in a siRNA concentration-dependent manner. by Shi Yun Leong (699834)

“…Parallel transfection of scrambled siRNA served as a knockdown control. MINK protein expression was observed to decrease in a dose-dependent manner across siRNA concentration. …”

Plasma amino acids and metabolic profiling of dairy cows in response to a bolus duodenal infusion of leucine by Hassan Sadri (771911)

“…The elevation of plasma Leu concentrations after the infusion led to a significant decrease (<i>P</i><0.05) in the plasma concentrations of isoleucine, valine, glycine, and alanine. …”

Mitochondrial Ca²⁺ uptake contributes to cell death induced by Aβ oligomers. by Sara Sanz-Blasco (271498)

“…<p><i>A</i>. Cerebellar granule cells were co-loaded with mitotracker green and TMRM 10 nM and washed. …”

Subsistence-level groups experiencing lifestyle change are a potential model for uncovering GxE interactions. by Amanda J. Lea (11790137)

“…Bidirectional arrows indicate factors that could either increase or decrease during urban transitions. (<b>B</b>) Studies such as The Turkana Health and Genomics Project [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002311#pbio.3002311.ref018" target="_blank">18</a>,<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002311#pbio.3002311.ref019" target="_blank">19</a>], The Orang Asli Health and Lifeways Project [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002311#pbio.3002311.ref020" target="_blank">20</a>], The Pacific Planetary Health Initiative, Madagascar Health and Environmental Research [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002311#pbio.3002311.ref021" target="_blank">21</a>–<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002311#pbio.3002311.ref023" target="_blank">23</a>], The Tsimane Health and Life History Project [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002311#pbio.3002311.ref024" target="_blank">24</a>], and The Shuar Health and Life History Project [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002311#pbio.3002311.ref025" target="_blank">25</a>,<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002311#pbio.3002311.ref026" target="_blank">26</a>] all combine anthropological and biomedical data collection in transitioning societies and are thus poised to uncover GxE interactions in the context of evolutionary mismatch. …”

TCF21 modulates expression of <i>AHR</i> and its downstream genes. by Juyong Brian Kim (4011689)

“…(e, f) TCF21 knockdown by siRNA decreased expression of both <i>IL1A</i> and <i>MMP1</i>, while dioxin alone increased expression of both genes. …”

Analysis of the various EcFicTA complexes in solution. by Frédéric V. Stanger (585551)

“…<p>(<i>a</i>) SEC-MALLS analysis of EcFicTA (green), EcFicTA_E28G (pink), EcFicT_G55RA (cyan) and EcFicT_G55RA_E28G (purple) reveals in each case a 1:1 complex in solution at an eluting concentration of 15 μM. …”

Rho-associated kinase and zipper-interacting protein kinase, but not myosin light chain kinase, are involved in the regulation of myosin phosphorylation in serum-stimulated human a... by Jing-Ti Deng (696563)

“…ROCK inhibition with GSK429286A reduced serum-induced phosphorylation of LC₂₀ at T18 and S19, MYPT1 at T853 and Par-4 at T163, while ZIPK inhibition by HS38 reduced only LC₂₀ diphosphorylation. …”

<i>Mycobacterium tuberculosis</i> universal stress protein Rv2623 interacts with the putative ATP binding cassette (ABC) transporter Rv1747 to regulate mycobacterial growth by Lisa N. Glass (4285222)

“…Biochemical, immunochemical and mass spectrometric studies have shown that Rv2623 harbors pT and specifically identified threonine 237 as a phosphorylated residue. Relative to wild-type Rv2623 (Rv2623_WT), a mutant protein in which T237 has been replaced with a non-phosphorylatable alanine (Rv2623_T237A) exhibits decreased interaction with the Rv1747 FHA I domain and diminished growth-regulatory capacity. …”

Abundance of antisense transcripts in <i>RTR1/RRP6</i> double deletion strain phenocopies <i>rrp6Δ</i> cells. by Jose F. Victorino (8595885)

“…Each genotype clustered together illustrating a high degree of reproducibility between biological replicates with WT values groups as Cluster IV, <i>rtr1Δ</i> values grouped as Cluster III, <i>rtr1Δ rrp6Δ</i> grouped as Cluster II, and <i>rrp6Δ</i> grouped as Cluster I. …”

In vivo validation of hippocampal avoidance with radiation in rats treated with brain irradiation with hippocampal avoidance. by C. K. Cramer (833725)

“…The radiation-induced phosphorylation of Histone H2A.X in the hippocampus is significantly decreased when the brain is irradiated with hippocampal avoidance, * P = 0.012 (by student t-test). …”

Presentation_1_Utility of a Novel Three-Dimensional and Dynamic (3DD) Cell Culture System for PK/PD Studies: Evaluation of a Triple Combination Therapy at Overcoming Anti-HER2 Trea... by Anusha Ande (724831)

“…In the 3DD cell culture setting, sequential dosing of PAC then EVE+DAS showed a 5-fold increase in caspase-3 activity and 8.5-fold decrease in the total cell number compared to the control. …”

Expression of osteoblast differentiation markers following <i>BST2</i> knockdown. by Su-Hyang Yoo (3160983)

Therapist rotation: a novel approach for implementation of trauma-focused treatment in post-traumatic stress disorder by Agnes Van Minnen (8060513)

“…We explore the experiences with this model from both a therapist and a patient perspective.<b>Results</b>: Our findings were promising in that they suggested that this novel approach reduced the therapists’ fear of providing TFT to PTSD patients, increased perceived readiness for TFT, and decreased avoidance behaviour within TFT sessions, possibly leading to better implementation of TFT. …”

AntagomiR-treated flies display metabolic defects similar to miR-275/305 mutants. by Junfei Xie (3148638)

“…<p>(A) miRNA inhibition efficiency was determined by qRT-PCR at 2 d post antagomiR injection with scrambled sequences as negative controls (Ant-NC). …”

Electrospun Polyimide Nanofiber-Based Triboelectric Nanogenerator for Harvesting Energy at Elevated Temperatures by Feilong Shi (13803714)

“…The PINF-TENG generated an open-circuit voltage of 60.83 V and a short-circuit current of 1.52 μA at 25 °C, and a peak power density of 17.36 mW/m² was achieved on a 50 MΩ external load. …”

The correlation between external apical root resorption and electric pulp test responses: a prospective clinical trial by Farnaz YOUNESSIAN (12853367)

“…Conclusion: The relative decrease in electric pulp test level could be a diagnostic sign of root resorption during orthodontic treatment. …”

Identifying Insects with Incomplete DNA Barcode Libraries, African Fruit Flies (Diptera: Tephritidae) as a Test Case by Massimiliano Virgilio (182967)

“…In all cases, more restrictive distance thresholds produced a gradual increase in the proportion of true negatives, a gradual decrease of false positives and more abrupt variations in the proportions of true positives and false negatives. …”

Purification, characterization, and antitumor activity of a novel glucan from the fruiting bodies of <i>Coriolus Versicolor</i> by Annoor Awadasseid (3726955)

“…Structural analysis revealed that CVG has a linear α-glucan chain composed of only (1→ 6)-α-D-Glc<i>p</i>. …”

Discovery of the Diphenyl 6‑Oxo-1,6-dihydropyridazine-3-carboxylate/carboxamide Analogue J27 for the Treatment of Acute Lung Injury and Sepsis by Targeting JNK2 and Inhibiting the... by Jing Liao (193197)

“…The optimal compound <b>J27</b> decreased the release of TNF-α and IL-6 in mouse and human cells J774A.1 and THP-1 (IL-6 IC₅₀ = 0.22 μM) through the NF-κB/MAPK pathway. …”

Discovery of the Diphenyl 6‑Oxo-1,6-dihydropyridazine-3-carboxylate/carboxamide Analogue J27 for the Treatment of Acute Lung Injury and Sepsis by Targeting JNK2 and Inhibiting the... by Jing Liao (193197)

“…The optimal compound <b>J27</b> decreased the release of TNF-α and IL-6 in mouse and human cells J774A.1 and THP-1 (IL-6 IC₅₀ = 0.22 μM) through the NF-κB/MAPK pathway. …”