Annexin A2 Is a Natural Extrahepatic Inhibitor of the PCSK9-Induced LDL Receptor Degradation by Nabil G. Seidah (148050)

“…Western blotting and immunohistochemistry of <em>AnxA2^−/−</em> tissues revealed that the LDLR was decreased by ∼50% in extrahepatic tissues, such as adrenals and colon. …”

Metformin attenuates V-domain Ig suppressor of T-cell activation through the aryl hydrocarbon receptor pathway in Melanoma: In Vivo and In Vitro Studies by Fawaz E., Alanazi

“…Melanoma is an aggressive skin cancer with a high rate of metastasis to other organs. Recent studies specified the overexpression of V-domain Ig suppressor of T-cell activation (VISTA) and Aryl Hydrocarbon Receptor (AHR) in melanoma. …”
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Supplementary file 1_Role and mechanism of IGFBP5 in the real-ambient particulate matter exposure-induced chronic lung injury.docx by Ningning Chen (509273)

“…We found that the upregulated hsa-miR-33a-5p repressed IGFBP5 translation by forming a silencing complex with Argonaute protein 2 (AGO2) in a real-ambient PM exposure system, which further led to the suppression of the ERK1/2-SOD2 signaling pathway and increased levels of ROS.…”

Protein Phosphatase 2A Controls Ethylene Biosynthesis by Differentially Regulating the Turnover of ACC Synthase Isoforms by Kyle R. Skottke (223882)

“…Surprisingly, <em>rcn1</em> plants exhibit decreased accumulation of the ACS5 protein, suggesting that a regulatory phosphorylation event leads to ACS5 destabilization. …”

Inhibition of Neuroblastoma Tumor Growth by Targeted Delivery of MicroRNA-34a Using Anti-Disialoganglioside GD₂ Coated Nanoparticles by Amanda Tivnan (163017)

“…These tumors express high levels of the cell surface antigen disialoganglioside GD2 (GD₂), providing a target for tumor-specific delivery.</p> <h3>Principal Findings</h3><p>Nanoparticles encapsulating miR-34a and conjugated to a GD₂ antibody facilitated tumor-specific delivery following systemic administration into tumor bearing mice, resulted in significantly decreased tumor growth, increased apoptosis and a reduction in vascularisation. …”

ETS1 Mediates MEK1/2-Dependent Overexpression of Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A) in Human Cancer Cells by Anchit Khanna (226950)

“…Moreover, MEK1/2-specific siRNAs decreased CIP2A protein expression. Series of CIP2A promoter-luciferase constructs were created to identify proximal −27 to −107 promoter region responsible for MEK-dependent stimulation of CIP2A expression. …”

Ustekinumab trough concentration are shown by responder status and anti-ustekinumab antibody (A) Patients with negative anti-ustekinumab antibody had significantly higher drug trou... by Hsien-Yi Chiu (799936)

Data_Sheet_2_Nutrient Inputs Stimulate Mercury Methylation by Syntrophs in a Subarctic Peatland.docx by Spencer Roth (11518552)

“…Rather, the concurrent additions of BES and molybdate significantly decreased k_meth, suggesting a role for interactions between SRB and methanogens in Hg methylation. …”

Supplementary Material for: Association of Four Genetic Loci with Uric Acid Levels and Reduced Renal Function: The J-SHIPP Suita Study by Tabara Y. (4123405)

“…<i>Background:</i> Recent genome-wide association studies have identified several genetic variants as susceptibility loci for serum uric acid (UA) levels. We also identified a common nonsense mutation, W258X, responsible for renal hypouricemia. …”

Table_1_Nutrient Inputs Stimulate Mercury Methylation by Syntrophs in a Subarctic Peatland.XLSX by Spencer Roth (11518552)

“…Rather, the concurrent additions of BES and molybdate significantly decreased k_meth, suggesting a role for interactions between SRB and methanogens in Hg methylation. …”

Translational block of cyclin A2 by <i>Ccna2</i>-MO causes embryos to arrest at the 2-cell stage. by Kira Foygel (268368)

“…<p>(<i>A</i>) <i>Ccna2</i> expression in 1- to 2-cell embryos by RT-PCR. …”

Data_Sheet_1_Nutrient Inputs Stimulate Mercury Methylation by Syntrophs in a Subarctic Peatland.DOCX by Spencer Roth (11518552)

“…Rather, the concurrent additions of BES and molybdate significantly decreased k_meth, suggesting a role for interactions between SRB and methanogens in Hg methylation. …”

Data Sheet 1_Toxoplasma gondii infection inhibits invasion and migration of human extravillous trophoblasts through dysregulation of FOXO1- and FOXO3a-dependent and -independent me... by Aurore Lebourg (22817522)

“…Transcription of genes encoding MMP3 and integrin β3 decreased in FOXO3a KD and FOXO1 KD EVT cell lines, respectively. …”

Data Sheet 1_Epigallocatechin-3-gallate protects against osteoarthritis-induced chondrocytes dysfunction by regulating PLa2g2a.pdf by Mengyuan Dai (9747317)

“…Background<p>Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage erosion, subchondral bone remodeling, and synovial inflammation. …”

Table_1_Reduced plasma levels of RGM-A predict stroke-associated pneumonia in patients with acute ischemic stroke: A prospective clinical study.DOCX by Jiaju Zhong (1632049)

“…An enzyme-linked immunosorbent assay was used to detect the plasma levels of RGM-A and interleukin-6.</p>Results<p>The plasma RGM-A levels were significantly decreased in both patients with community-acquired pneumonia and those with AIS, and the decline was most pronounced in patients with SAP (P < 0.001). …”

Data_Sheet_1_The dynamic transcriptome during maturation of biofilms formed by methicillin-resistant Staphylococcus aureus.docx by Jelle Vlaeminck (13166814)

“…In intermediate (48 h) and late (72 h) stages of biofilms, decreased expression of central metabolic and fermentative pathways (glycolysis/gluconeogenesis, fatty acid biosynthesis), indicating a shift to anaerobic conditions, was already evident in USA300 and HEMRSA-15 in 48-h biofilm cultures; ST239 showed a similar profile at 72 h. …”

Table 1_Demethylase FTO mediates m6A modification of ENST00000619282 to promote apoptosis escape in rheumatoid arthritis and the intervention effect of Xinfeng Capsule.docx by Fanfan Wang (1669474)

“…Introduction<p>The pathological mechanisms of rheumatoid arthritis (RA) are closely associated with the apoptosis escape of fibroblast-like synoviocytes (FLS). The m6A modification of long non-coding RNAs (lncRNAs) plays a critical regulatory role in RA pathogenesis. …”

HDACi-resistant HCT-R cells exhibit high expression levels of pAKT, a downstream effector of WNT5A and ROR2. by Michael Bordonaro (340595)

“…<p>(A) HDACi-resistant HCT-R cells express higher levels of pAKT than HDACi-sensitive HCT-116 cells. …”

NO inhibition (L-NAME) <i>in viv</i>o results in increasing outward current in some PNs (A, B, C) and decreasing inward current in others (D, E, F). by Mark Higgins (312833)

“…<p><b>A</b>. Representative traces of net outward currents elicited by the depolarization protocol (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0042556#pone-0042556-g001" target="_blank">figure 1</a>) before (saline), 30 min. after treatment with L-NAME, and the difference (L-NAME - Saline). …”

Illustrative images of the processing of a myocardial perfusion study in a patient with Chagas disease. by Káryta Suely Macêdo Martins (22404155)