Discovery of an eIF4A Inhibitor with a Novel Mechanism of Action by Christopher J. Zerio (11595690)

“…A medicinal chemistry campaign produced the novel eIF4A inhibitor <b>28</b>, which decreased BJAB Burkitt lymphoma cell viability. …”

Discovery of an eIF4A Inhibitor with a Novel Mechanism of Action by Christopher J. Zerio (11595690)

“…A medicinal chemistry campaign produced the novel eIF4A inhibitor <b>28</b>, which decreased BJAB Burkitt lymphoma cell viability. …”

Discovery of an eIF4A Inhibitor with a Novel Mechanism of Action by Christopher J. Zerio (11595690)

“…A medicinal chemistry campaign produced the novel eIF4A inhibitor <b>28</b>, which decreased BJAB Burkitt lymphoma cell viability. …”

Structural Basis for Sequence Specific DNA Binding and Protein Dimerization of HOXA13 by Yonghong Zhang (20918)

“…I366 makes similar methyl contacts with T3* and T4*. Mutants (I366A, N370A and V373G) all have decreased DNA binding and transcriptional activity. …”

<i>Cotton Leaf Curl Multan virus</i> C4 protein suppresses both transcriptional and post-transcriptional gene silencing by interacting with SAM synthetase by Asigul Ismayil (5698946)

“…Plants infected with CLCuMuV carrying C4^R13A show decreased levels of symptoms and viral DNA accumulation associated with enhanced viral DNA methylation. …”

The multicopy sRNA LhrC controls expression of the oligopeptide-binding protein OppA in <i>Listeria monocytogenes</i> by Susanne Sievers (256439)

“…For OppA, we show that LhrC acts by direct base paring to the ribosome binding site of the <i>oppA</i> mRNA, leading to an impediment of its translation and a decreased mRNA level. …”

A R13A point mutation in C4 attenuates CLCuMuV infection. by Asigul Ismayil (5698946)

“…<b>(C)</b> The mutant CLCuMuV carrying C4^R13A (CLCuMuV-C4^R13A), which contains a R13A mutation in <i>C4</i>, showed the decreased viral symptom compared to wild type CLCuMuV. …”

Induction of immunomodulatory miR-146a and miR-155 in small intestinal epithelium of <i>Vibrio cholerae</i> infected patients at acute stage of cholera by Aziz Bitar (257322)

“…Only marginal down-regulation of target genes IRAK1 and CARD10 was seen and a weak cytokine-profile was identified in the acute infected mucosa. …”

A graph showing the surface roughness values of the test specimen after tests with different slide-to-roll ratios (a) Ra, Rq (b) Rz (c) Sa, Sq (d) Sz, Sp, Sv. by Yang Li (7082)

Oxidative stress in early metabolic syndrome impairs cardiac RyR2 and SERCA2a activity and modifies the interplay of these proteins during Ca²⁺ waves by Norma Leticia Gómez-Viquez (10285471)

“…We hypothesised that OS decreases RyR2/SERCA2a activity at early MetS, and while decreased SERCA2a favours CaW propagation, diminished RyR2 restrains it.…”

Amylase reportable results (2009–2022). by Naga Sasidhar Kanaparthy (17691740)

Effects of EsA on CCl₄-induced liver oxidative stress. by Fang Zhang (197215)

“…<p>EsA treatment significantly decreased levels of MDA (A) and increased the activity of GSH-Px (B) compared with the Injury group. …”

Real time PCR results of AR target-genes known to regulate trophoblast differentiation and proliferation. by Ellane R. Cleys (692077)

“…<i>IGFBP2</i> also decreased in type A and D placentomes from TP treated ewes compared to control type A placentomes. …”

Data_Sheet_2_Associations of the miRNA-146a rs2910164 and the miRNA-499a rs3746444 Polymorphisms With Plasma Lipid Levels: A Meta-Analysis.doc by Fuqiang Liu (451879)

“…The standardized mean difference (SMD) and 95% confidence interval (CI) were used to evaluate the differences in lipid levels between the genotypes. rs2910164, a functional polymorphism in the miRNA-146a gene, was associated with increased triglycerides (TG) (SMD = 0.35, 95% CI = 0.15–0.54, p < 0.001), total cholesterol (TC) (SMD = 0.43, 95% CI = 0.16–0.70, p < 0.001), and low-density lipoprotein cholesterol (LDL-C) (SMD = 0.37, 95% CI = 0.11–0.63, p = 0.01) as well as decreased high-density lipoprotein cholesterol (HDL-C) (SMD = −0.27, 95% CI = −0.47−0.07, p = 0.01) levels. rs3746444, a functional polymorphism in the miRNA-499a gene, was only correlated with decreased TG (SMD = −0.09, 95% CI = −0.17−0.01, P = 0.03) levels.…”

Data_Sheet_1_Associations of the miRNA-146a rs2910164 and the miRNA-499a rs3746444 Polymorphisms With Plasma Lipid Levels: A Meta-Analysis.docx by Fuqiang Liu (451879)

“…The standardized mean difference (SMD) and 95% confidence interval (CI) were used to evaluate the differences in lipid levels between the genotypes. rs2910164, a functional polymorphism in the miRNA-146a gene, was associated with increased triglycerides (TG) (SMD = 0.35, 95% CI = 0.15–0.54, p < 0.001), total cholesterol (TC) (SMD = 0.43, 95% CI = 0.16–0.70, p < 0.001), and low-density lipoprotein cholesterol (LDL-C) (SMD = 0.37, 95% CI = 0.11–0.63, p = 0.01) as well as decreased high-density lipoprotein cholesterol (HDL-C) (SMD = −0.27, 95% CI = −0.47−0.07, p = 0.01) levels. rs3746444, a functional polymorphism in the miRNA-499a gene, was only correlated with decreased TG (SMD = −0.09, 95% CI = −0.17−0.01, P = 0.03) levels.…”

Placentome morphology and fetal weight. by Ellane R. Cleys (692077)

“…<p><b>A</b>) Testosterone propionate treatment (TP) decreased the number of type A placentomes, and increased type C and type D placentomes collected at gestational day 90. …”

The ω Subunit of RNA Polymerase Is Essential for Thermal Acclimation of the Cyanobacterium <i>Synechocystis</i> Sp. PCC 6803 by Liisa Gunnelius (658400)

“…<div><p>The <i>rpoZ</i> gene encodes the small ω subunit of RNA polymerase. A ΔrpoZ strain of the cyanobacterium <i>Synechocystis</i> sp. …”

RQ₁₀ and Q₁₀ production (pmol/mg wet pellet) in <i>R</i>. <i>rubrum</i> mutant strains from LC-MS analysis. by Amanda R. M. Campbell (6719102)

“…<p>A. Anaerobic growth conditions with RQ₁₀ production designated with dark grey bars and Q₁₀ with light grey bars. …”

Differential levels of epigenetic regulators with TP treatment. by Ellane R. Cleys (692077)

“…<p>Analysis of relative mRNA levels for genes regulating histone and DNA methylation and imprinting in ovine placentome tissue from real time PCR. <i>KDM4C</i> was decreased in type A placentomes from TP treated ewes compared to controls. …”

EsA protected against GalN/LPS-induced histopathological damage and hepatic dysfunction. by Fang Zhang (197215)

“…Levels of AST and ALT increased obviously after GalN/LPS challenge, and which were significantly decreased with EsA treatment (n = 6 C). The values presented are the means ± standard error of the mean. …”