Screen candidates modify the expression of RAS/MAPK components. by Dariel Ashton-Beaucage (538989)

“…(D) Also in agreement with the qPCR data, a specific decrease in PTP-ER levels was observed upon depletion of <i>CG4936</i>.…”

PRDM9 binds in vitro to meiotic recombination hotspots. by Corinne Grey (200646)

“…The amount of signal due to binding of each probe to PRDM9^wm7 is shown (with standard error), relative to <i>Psmb9^TC</i>. The decrease of binding to the double mutant probe <i>Psmb9</i>^CT (0.07% binding relative to <i>Psmb9</i>^TC) is consistent with a cumulative effect of each single mutant (0.36% and 0.14% binding relative to <i>Psmb9</i>^TC) suggesting their effects are independent. …”

Secondary structure probabilities. by Vinal V. Lakhani (249536)

“…In the context of Q_n, however, the glutamine residues for long Q_n lengths have an increase in β-strand probability and a decrease in the random coil probability (data not shown). …”

Differentially methylated regions interrogated for metastable epialleles associate with offspring adiposity by Stephanie W Waldrop (19653383)

“…</p> <p>DNAm of MEs has been suggested to play a role in energy balance and has previously been associated with obesity in adult and pediatric populations.…”

Data_Sheet_1_Fatigue Induced by Repeated Changes of Direction in Élite Female Football (Soccer) Players: Impact on Lower Limb Biomechanics and Implications for ACL Injury Preventio... by Matteo Zago (5721068)

“…Measures of exercise internal load were: peak post-exercise blood lactate concentration, heart rate (HR) and perceived exertion. Continuous linear correlations between kinematics/kinetics waveforms (during the ground contact phase of the pivoting limb) and the number of consecutive CoD were computed during the exercise using a Statistical Parametric Mapping (SPM) approach.…”

Image 1_Epimedium brevicornu Maxim. extract activates natural killer cells against hepatocellular carcinoma via the cGAS-STING pathway.tif by Lu Liu (171341)

“…Background<p>Epimedium brevicornu: Maxim., a traditional Chinese botanical drug, has shown significant therapeutic effects against hepatocellular carcinoma (HCC), with its flavonoid compounds exhibiting anti-HCC activity through various mechanisms. …”

DataSheet1_Extracts of Andrographis paniculata (Burm.f.) Nees Leaves Exert Anti-Gout Effects by Lowering Uric Acid Levels and Reducing Monosodium Urate Crystal-Induced Inflammation... by Eldiza Puji Rahmi (8584506)

“…In the XO inhibitory activity, none of the samples exhibited greater than 50% inhibition. However, in a rat model, EtOH80 extract (200 mg/kg/day) and andrographolide (30 mg/kg/day) decreased serum uric acid levels and reduced liver XO activity, reduced the protein expression levels of URAT1 and GLUT9, and restored the decrease in OAT1 levels. …”

Developmental effects of auxin in the <i>M</i>. <i>polymorpha</i> thallus. by Eduardo Flores-Sandoval (746468)

“…<b>(L)</b> Ventral side of wild-type thallus grown on 100 μM L-Kyn; a decrease in rhizoid number exposes ventral scales. …”

Three Generic Nevirapine-Based Antiretroviral Treatments in Chinese HIV/AIDS Patients: Multicentric Observation Cohort by Taisheng Li (269024)

“…At week 52, suppression of plasma HIV-1 RNA to less than 50 copies/ml was achieved in more patients in group B and C than in group A (68.2%, 69% vs. 39.7%; p<0.001). In planned subgroup analyses, the decrease of viral response rate was seen in group A when CD4 cell count >200/ul (subgroup H). …”

<i>Oxtr</i> promoter methylation changes <i>in vivo</i>. by Shimrat Mamrut (283008)

“…<b>C</b>) The mean difference in the methylation of the seven examined CpG sites, between early postpartum and virgin females. A general increase is observed in the mammary glands while a general decrease is evident in the uterus. …”

Image 3_Low CD46 expression on activated CD4+ T cells predict improved Th1 cell reactivity to calcitriol in majority of patients with allergic eosinophilic asthma and healthy donor... by Julie Stichova (19729855)

“…However, in both cohorts were individuals (HDs: 35/49, AEA: 40/58) who responded to calcitriol with a more pronounced regulatory response. The calcitriol-induced regulatory effect manifested by a stronger surface decrease of CD46 on activated CD4⁺ T cells (by 40% in HDs and by 26% in AEA), accompanied by a significant inhibition of IFN-γ and increased IL-10 production (by 31% in HDs and by 85% in AEA). …”

Presenting symptoms. by Tamrat Petros Elias (18536434)

“…<div><p>Background</p><p>Post-acute COVID-19 syndrome is a condition where individuals experience persistent symptoms after the acute phase of the COVID-19 infection has resolved, which lowers their quality of life and ability to return to work. …”

ACTIIR Inhibition in Murine Ischemic Heart Failure - Supplementary Figures by Estibaliz Castillero (6715277)

“…ACTRII/TGFBR inhibition increased sarco/endoplasmic reticulum Ca2+-ATPase (SERCA2a) levels and decreased unfolded protein response (UPR) markers in MI mice. …”

Ability of N variants to support transcription re-initiation at every MeV intergenic region (IGR) as determined using dual-luciferase 2-gene minigenomes coding for Firefly and Nano... by Louis-Marie Bloyet (598416)

“…(<b>b</b>) Homogenous and comparable decrease of the efficiency of the transcription re-initiation mediated by every MeV IGR from 3’ to 5’ gene position observed with every N variant when the NanoLuc/Firefly signal ratio is normalized as a function of that observed with the first N-P IGR. …”

Comorbidity pattern of patients. by Tamrat Petros Elias (18536434)

“…<div><p>Background</p><p>Post-acute COVID-19 syndrome is a condition where individuals experience persistent symptoms after the acute phase of the COVID-19 infection has resolved, which lowers their quality of life and ability to return to work. …”

Red Blood Cell Transfusion and Mortality in Trauma Patients: Risk-Stratified Analysis of an Observational Study by Pablo Perel (102217)

“…Transfusion was associated with an increase in all-cause mortality among patients with &lt;6% and 6%–20% predicted risk of death (odds ratio [OR] 5.40, 95% CI 4.08–7.13, <i>p&lt;</i>0.0001, and OR 2.31, 95% CI 1.96–2.73, <i>p&lt;</i>0.0001, respectively), but with a decrease in all-cause mortality in patients with &gt;50% predicted risk of death (OR 0.59, 95% CI 0.47–0.74, <i>p&lt;</i>0.0001). …”

Image 1_Low CD46 expression on activated CD4+ T cells predict improved Th1 cell reactivity to calcitriol in majority of patients with allergic eosinophilic asthma and healthy donor... by Julie Stichova (19729855)

“…However, in both cohorts were individuals (HDs: 35/49, AEA: 40/58) who responded to calcitriol with a more pronounced regulatory response. The calcitriol-induced regulatory effect manifested by a stronger surface decrease of CD46 on activated CD4⁺ T cells (by 40% in HDs and by 26% in AEA), accompanied by a significant inhibition of IFN-γ and increased IL-10 production (by 31% in HDs and by 85% in AEA). …”

Image 4_Low CD46 expression on activated CD4+ T cells predict improved Th1 cell reactivity to calcitriol in majority of patients with allergic eosinophilic asthma and healthy donor... by Julie Stichova (19729855)

“…However, in both cohorts were individuals (HDs: 35/49, AEA: 40/58) who responded to calcitriol with a more pronounced regulatory response. The calcitriol-induced regulatory effect manifested by a stronger surface decrease of CD46 on activated CD4⁺ T cells (by 40% in HDs and by 26% in AEA), accompanied by a significant inhibition of IFN-γ and increased IL-10 production (by 31% in HDs and by 85% in AEA). …”

Patient selection for this study. by Tamrat Petros Elias (18536434)

“…<div><p>Background</p><p>Post-acute COVID-19 syndrome is a condition where individuals experience persistent symptoms after the acute phase of the COVID-19 infection has resolved, which lowers their quality of life and ability to return to work. …”

DataSheet1_Extracts of Andrographis paniculata (Burm.f.) Nees Leaves Exert Anti-Gout Effects by Lowering Uric Acid Levels and Reducing Monosodium Urate Crystal-Induced Inflammation... by Eldiza Puji Rahmi (8584506)

“…In the XO inhibitory activity, none of the samples exhibited greater than 50% inhibition. However, in a rat model, EtOH80 extract (200 mg/kg/day) and andrographolide (30 mg/kg/day) decreased serum uric acid levels and reduced liver XO activity, reduced the protein expression levels of URAT1 and GLUT9, and restored the decrease in OAT1 levels. …”